| An anticancer drug suppresses the primary nucleation reaction that initiates the production of the toxic Aβ42 aggregates linked with Alzheimer’s disease J Habchi, P Arosio, M Perni, AR Costa, M Yagi-Utsumi, P Joshi, S Chia, ... Science advances 2 (2), e1501244, 2016 | 221 | 2016 |
| Cholesterol catalyses Aβ42 aggregation through a heterogeneous nucleation pathway in the presence of lipid membranes J Habchi, S Chia, C Galvagnion, TCT Michaels, MMJ Bellaiche, ... Nature chemistry 10 (6), 673-683, 2018 | 220 | 2018 |
| Systematic development of small molecules to inhibit specific microscopic steps of Aβ42 aggregation in Alzheimer’s disease J Habchi, S Chia, R Limbocker, B Mannini, M Ahn, M Perni, O Hansson, ... Proceedings of the National Academy of Sciences 114 (2), E200-E208, 2017 | 208 | 2017 |
| Chemical kinetics for bridging molecular mechanisms and macroscopic measurements of amyloid fibril formation TCT Michaels, A Šarić, J Habchi, S Chia, G Meisl, M Vendruscolo, ... Annual review of physical chemistry 69, 273-298, 2018 | 195 | 2018 |
| Trodusquemine enhances Aβ42 aggregation but suppresses its toxicity by displacing oligomers from cell membranes R Limbocker, S Chia, FS Ruggeri, M Perni, R Cascella, GT Heller, G Meisl, ... Nature communications 10 (1), 225, 2019 | 134 | 2019 |
| Transthyretin inhibits primary and secondary nucleations of amyloid-β peptide aggregation and reduces the toxicity of its oligomers SA Ghadami, S Chia, FS Ruggeri, G Meisl, F Bemporad, J Habchi, ... Biomacromolecules 21 (3), 1112-1125, 2020 | 62 | 2020 |
| SAR by kinetics for drug discovery in protein misfolding diseases S Chia, J Habchi, TCT Michaels, SIA Cohen, S Linse, CM Dobson, ... Proceedings of the National Academy of Sciences 115 (41), 10245-10250, 2018 | 62 | 2018 |
| Infrared nanospectroscopy reveals the molecular interaction fingerprint of an aggregation inhibitor with single Aβ42 oligomers FS Ruggeri, J Habchi, S Chia, RI Horne, M Vendruscolo, TPJ Knowles Nature Communications 12 (1), 688, 2021 | 58 | 2021 |
| Monomeric and fibrillar α-synuclein exert opposite effects on the catalytic cycle that promotes the proliferation of Aβ42 aggregates S Chia, P Flagmeier, J Habchi, V Lattanzi, S Linse, CM Dobson, ... Proceedings of the National Academy of Sciences 114 (30), 8005-8010, 2017 | 57 | 2017 |
| Trodusquemine displaces protein misfolded oligomers from cell membranes and abrogates their cytotoxicity through a generic mechanism R Limbocker, B Mannini, FS Ruggeri, R Cascella, CK Xu, M Perni, S Chia, ... Communications biology 3 (1), 435, 2020 | 53 | 2020 |
| Microfluidic deposition for resolving single-molecule protein architecture and heterogeneity FS Ruggeri, J Charmet, T Kartanas, Q Peter, S Chia, J Habchi, ... Nature communications 9 (1), 1-12, 2018 | 49 | 2018 |
| Stabilization and Characterization of Cytotoxic Aβ40 Oligomers Isolated from an Aggregation Reaction in the Presence of Zinc Ions B Mannini, J Habchi, S Chia, FS Ruggeri, M Perni, TPJ Knowles, ... ACS chemical neuroscience 9 (12), 2959-2971, 2018 | 47 | 2018 |
| Squalamine and its derivatives modulate the aggregation of amyloid-β and α-synuclein and suppress the toxicity of their oligomers R Limbocker, R Staats, S Chia, FS Ruggeri, B Mannini, CK Xu, M Perni, ... Frontiers in Neuroscience 15, 680026, 2021 | 40 | 2021 |
| A fragment-based method of creating small-molecule libraries to target the aggregation of intrinsically disordered proteins P Joshi, S Chia, J Habchi, TPJ Knowles, CM Dobson, M Vendruscolo ACS combinatorial science 18 (3), 144-153, 2016 | 38 | 2016 |
| Screening of small molecules using the inhibition of oligomer formation in α-synuclein aggregation as a selection parameter R Staats, TCT Michaels, P Flagmeier, S Chia, RI Horne, J Habchi, S Linse, ... Communications Chemistry 3 (1), 191, 2020 | 35 | 2020 |
| A dopamine metabolite stabilizes neurotoxic amyloid-β oligomers R Cataldi, S Chia, K Pisani, FS Ruggeri, CK Xu, T Šneideris, M Perni, ... Communications biology 4 (1), 19, 2021 | 33 | 2021 |
| Surface-catalyzed secondary nucleation dominates the generation of toxic IAPP aggregates DC Rodriguez Camargo, S Chia, J Menzies, B Mannini, G Meisl, ... Frontiers in Molecular Biosciences 8, 1037, 2021 | 26 | 2021 |
| Structure-based discovery of small-molecule inhibitors of the autocatalytic proliferation of α-Synuclein aggregates S Chia, Z Faidon Brotzakis, RI Horne, A Possenti, B Mannini, R Cataldi, ... Molecular Pharmaceutics 20 (1), 183-193, 2022 | 24 | 2022 |
| Complexity in Lipid Membrane Composition Induces Resilience to Aβ42 Aggregation M Sanguanini, KN Baumann, S Preet, S Chia, J Habchi, TPJ Knowles, ... ACS Chemical Neuroscience 11 (9), 1347-1352, 2020 | 24 | 2020 |
| Proliferation of tau 304–380 fragment aggregates through autocatalytic secondary nucleation DC Rodriguez Camargo, E Sileikis, S Chia, E Axell, K Bernfur, RL Cataldi, ... ACS Chemical Neuroscience 12 (23), 4406-4415, 2021 | 22 | 2021 |
