| Thiophene derivatives as new mechanism-based inhibitors of cytochromes P-450: inactivation of yeast-expressed human liver cytochrome P-450 2C9 by tienilic acid MP Lopez-Garcia, PM Dansette, D Mansuy Biochemistry 33 (1), 166-175, 1994 | 225 | 1994 |
| Human‐liver cytochromes P‐450 expressed in yeast as tools for reactive‐metabolite formation studies: Oxidative activation of tienilic acid by cytochromes P‐450 … MP LOPEZ GARCIA, PM Dansette, P Valadon, C Amar, PH Beaune, ... European Journal of Biochemistry 213 (1), 223-232, 1993 | 128 | 1993 |
| Substrate selectivity of human cytochrome P450 2C9: importance of residues 476, 365, and 114 in recognition of diclofenac and sulfaphenazole and in mechanism-based inactivation … A Melet, N Assrir, P Jean, MP Lopez-Garcia, C Marques-Soares, ... Archives of Biochemistry and Biophysics 409 (1), 80-91, 2003 | 123 | 2003 |
| Culture of human hepatocytes from small surgical liver biopsies. Biochemical characterization and comparison with in vivo MJ Gómez-Lechón, P López, T Donato, A Montoya, A Larrauri, P Giménez, ... In Vitro Cellular & Developmental Biology-Plant 26 (1), 67-74, 1990 | 115 | 1990 |
| Biochemical functionality and recovery of hepatocytes after deep freezing storage MJ Comez-L, P Lopez, JV Castell In Vitro Cellular & Developmental Biology-Plant 20 (11), 826-832, 1984 | 104 | 1984 |
| Thiophene S-oxides as new reactive metabolites: formation by cytochrome P-450 dependent oxidation and reaction with nucleophiles D Mansuy, P Valadon, I Erdelmeier, P Lopez-Garcia, C Amar, JP Girault, ... Journal of the American Chemical Society 113 (20), 7825-7826, 1991 | 100 | 1991 |
| Oxidation of Tienilic Acid by Human Yeast‐Expressed Cytochromes P‐450 2C8, 2C9, 2C18 and 2C19: Evidence that this Drug is A Mechanism‐Based Inhibitor Specific for … P Jean, P Lopez‐Garcia, P Dansette, D Mansuy, JL Goldstein European journal of biochemistry 241 (3), 797-804, 1996 | 83 | 1996 |
| Endogenous nitric oxide is responsible for the early loss of P450 in cultured rat hepatocytes MP López-Garcı́a FEBS letters 438 (3), 145-149, 1998 | 60 | 1998 |
| Nitric oxide-scavenging properties of some chalcone derivatives F Herencia, MP López-García, A Ubeda, ML Ferrándiz Nitric oxide 6 (2), 242-246, 2002 | 49 | 2002 |
| The potential use of cultured hepatocytes in predicting the hepatotoxicity of xenobiotics MJ Gómez-Lechón, A Montoya, P López, T Donato, A Larrauri, JV Castell Xenobiotica 18 (6), 725-735, 1988 | 41 | 1988 |
| Differential sensitivity of rat hepatocyte CYP isoforms to self‐generated nitric oxide S Vernia, P Beaune, J Coloma, MP López-Garcı́a FEBS letters 488 (1-2), 59-63, 2001 | 28 | 2001 |
| Peroxynitrite generated from constitutive nitric oxide synthase mediates the early biochemical injury in short-term cultured hepatocytes MP López-Garcı́a, SM Sanz-González FEBS letters 466 (1), 187-191, 2000 | 28 | 2000 |
| Effects of benorylate and impacina on the metabolism of cultured hepatocytes JV Castell, A Montoya, A Larrauri, P López, MJ Gómez-Lechón Xenobiotica 15 (8-9), 743-749, 1985 | 28 | 1985 |
| Glycogen synthesis in serum-free cultured hepatocytes in response to insulin and dexamethasone MP Lopez, MJ Gomez-Lechon, JV Castell In Vitro Cellular & Developmental Biology-Plant 20 (12), 923-931, 1984 | 28 | 1984 |
| Involvement of peroxynitrite on the early loss of p450 in short-term hepatocyte cultures S Vernia, SM Sanz-González, MP López-García Biological Reactive Intermediates VI: Chemical and Biological Mechanisms in …, 2001 | 27 | 2001 |
| Kinetics of tienilic acid bioactivation and functional generation of drug–protein adducts in intact rat hepatocytes MP López-García, PM Dansette, J Coloma Biochemical pharmacology 70 (12), 1870-1882, 2005 | 23 | 2005 |
| Role of glucose, insulin, and glucagon in glycogen mobilization in human hepatocytes. MP López, MJ Gomez-Lechon, JV Castell Diabetes 40 (2), 263-268, 1991 | 22 | 1991 |
| A cytochemical stain for glutathione in rat hepatocytes cultured on plastic. A Larrauri, P Lopez, MJ Gómez-Lechón, JV Castell Journal of Histochemistry & Cytochemistry 35 (2), 271, 1987 | 19 | 1987 |
| An experimental design for the controlled modulation of intracellular GSH levels in cultured hepatocytes G Esteban-Pretel, MP López-García Free Radical Biology and Medicine 41 (4), 610-619, 2006 | 16 | 2006 |
| Active glycolysis and glycogenolysis in early stages of primary cultured hepatocytes. Role of AMP and fructose 2.6-bisphosphate MP López, MJ Gómez-Lechón, JV Castell In Vitro Cellular & Developmental Biology-Plant 24 (6), 511-517, 1988 | 16 | 1988 |
