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Tim Tree
Tim Tree
Professor of Immune Regulation and Immunotherapy, King's College London
Verified email at kcl.ac.uk
Title
Cited by
Cited by
Year
Guidelines for the use of flow cytometry and cell sorting in immunological studies
A Cossarizza, HD Chang, A Radbruch, A Acs, D Adam, S Adam‐Klages, ...
European journal of immunology 49 (10), 1457-1973, 2019
17242019
Defective suppressor function in CD4+ CD25+ T-cells from patients with type 1 diabetes
S Lindley, CM Dayan, A Bishop, BO Roep, M Peakman, TIM Tree
Diabetes 54 (1), 92-99, 2005
11392005
Safety and immunogenicity of one versus two doses of the COVID-19 vaccine BNT162b2 for patients with cancer: interim analysis of a prospective observational study
L Monin, AG Laing, M Muñoz-Ruiz, DR McKenzie, IDM Del Barrio, ...
The Lancet Oncology 22 (6), 765-778, 2021
5912021
Autoreactive T cell responses show proinflammatory polarization in diabetes but a regulatory phenotype in health
S Arif, TI Tree, TP Astill, JM Tremble, AJ Bishop, CM Dayan, BO Roep, ...
The Journal of clinical investigation 113 (3), 451-463, 2004
5832004
CTLs are targeted to kill β cells in patients with type 1 diabetes through recognition of a glucose-regulated preproinsulin epitope
A Skowera, RJ Ellis, R Varela-Calviño, S Arif, GC Huang, C Van-Krinks, ...
The Journal of clinical investigation 118 (10), 3390-3402, 2008
4552008
Peripheral and islet interleukin-17 pathway activation characterizes human autoimmune diabetes and promotes cytokine-mediated β-cell death
S Arif, F Moore, K Marks, T Bouckenooghe, CM Dayan, R Planas, ...
Diabetes 60 (8), 2112-2119, 2011
2602011
Type 1 diabetes-associated IL2RA variation lowers IL-2 signaling and contributes to diminished CD4+ CD25+ regulatory T cell function
G Garg, JR Tyler, JHM Yang, AJ Cutler, K Downes, M Pekalski, GL Bell, ...
The Journal of Immunology 188 (9), 4644-4653, 2012
2452012
Increased resistance to CD4+CD25hi regulatory T cell-mediated suppression in patients with type 1 diabetes
JM Lawson, J Tremble, C Dayan, H Beyan, RDG Leslie, M Peakman, ...
Clinical & Experimental Immunology 154 (3), 353-359, 2008
2202008
Regulatory T cell dysfunction in type 1 diabetes: what’s broken and how can we fix it?
CM Hull, M Peakman, TIM Tree
Diabetologia 60 (10), 1839-1850, 2017
1932017
Metabolic and immune effects of immunotherapy with proinsulin peptide in human new-onset type 1 diabetes
M Alhadj Ali, YF Liu, S Arif, D Tatovic, H Shariff, VB Gibson, N Yusuf, ...
Science translational medicine 9 (402), eaaf7779, 2017
1882017
The effect of methotrexate and targeted immunosuppression on humoral and cellular immune responses to the COVID-19 vaccine BNT162b2: a cohort study
SK Mahil, K Bechman, A Raharja, C Domingo-Vila, D Baudry, MA Brown, ...
The Lancet Rheumatology 3 (9), e627-e637, 2021
1652021
Systemic inflammatory response and neuromuscular involvement in amyotrophic lateral sclerosis
CH Lu, K Allen, F Oei, E Leoni, J Kuhle, T Tree, P Fratta, N Sharma, ...
Neurology: Neuroimmunology & Neuroinflammation 3 (4), e244, 2016
1592016
Immune modulation in humans: implications for type 1 diabetes mellitus
BO Roep, TIM Tree
Nature Reviews Endocrinology 10 (4), 229-242, 2014
1552014
CD 161 expression characterizes a subpopulation of human regulatory T cells that produces IL‐17 in a STAT 3‐dependent manner
B Afzali, PJ Mitchell, FC Edozie, GAM Povoleri, SE Dowson, L Demandt, ...
European journal of immunology 43 (8), 2043-2054, 2013
1532013
Phenotypic complexity of the human regulatory T cell compartment revealed by mass cytometry
GM Mason, K Lowe, R Melchiotti, R Ellis, E de Rinaldis, M Peakman, ...
The Journal of Immunology 195 (5), 2030-2037, 2015
1502015
Regulatory T cell responses in participants with type 1 diabetes after a single dose of interleukin-2: a non-randomised, open label, adaptive dose-finding trial
JA Todd, M Evangelou, AJ Cutler, ML Pekalski, NM Walker, HE Stevens, ...
PLoS medicine 13 (10), e1002139, 2016
1442016
Plasmacytoid dendritic cells are proportionally expanded at diagnosis of type 1 diabetes and enhance islet autoantigen presentation to T-cells through immune complex capture
JS Allen, K Pang, A Skowera, R Ellis, C Rackham, B Lozanoska-Ochser, ...
Diabetes 58 (1), 138-145, 2009
1382009
Naturally arising human CD4 T-cells that recognize islet autoantigens and secrete interleukin-10 regulate proinflammatory T-cell responses via linked suppression
TIM Tree, J Lawson, H Edwards, A Skowera, S Arif, BO Roep, M Peakman
Diabetes 59 (6), 1451-1460, 2010
1182010
Generation of human islet-specific regulatory T cells by TCR gene transfer
CM Hull, LE Nickolay, M Estorninho, MW Richardson, JL Riley, ...
Journal of autoimmunity 79, 63-73, 2017
1162017
C-peptide decline in type 1 diabetes has two phases: an initial exponential fall and a subsequent stable phase
BM Shields, TJ McDonald, R Oram, A Hill, M Hudson, P Leete, ...
Diabetes care 41 (7), 1486-1492, 2018
1032018
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