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Brian Leber
Brian Leber
Professor of Medicine, McMaster University
Verified email at mcmaster.ca
Title
Cited by
Cited by
Year
Azacitidine and venetoclax in previously untreated acute myeloid leukemia
CD DiNardo, BA Jonas, V Pullarkat, MJ Thirman, JS Garcia, AH Wei, ...
New England Journal of Medicine 383 (7), 617-629, 2020
20912020
Telomerase activity in normal leukocytes and in hematologic malignancies
CM Counter, J Gupta, CB Harley, B Leber, S Bacchetti
11831995
Mitochondrio‐nuclear translocation of AIF in apoptosis and necrosis
E Daugas, SA Susin, N Zamzami, KF Ferri, T Irinopoulou, N Larochette, ...
The FASEB Journal 14 (5), 729-739, 2000
10792000
Mechanisms of action of Bcl-2 family proteins
A Shamas-Din, J Kale, B Leber, DW Andrews
Cold Spring Harbor perspectives in biology 5 (4), a008714, 2013
8882013
Membrane binding by tBid initiates an ordered series of events culminating in membrane permeabilization by Bax
JF Lovell, LP Billen, S Bindner, A Shamas-Din, C Fradin, B Leber, ...
Cell 135 (6), 1074-1084, 2008
7042008
Identification of drugs including a dopamine receptor antagonist that selectively target cancer stem cells
E Sachlos, RM Risueño, S Laronde, Z Shapovalova, JH Lee, J Russell, ...
Cell 149 (6), 1284-1297, 2012
5722012
BH3-only proteins: Orchestrators of apoptosis
A Shamas-Din, H Brahmbhatt, B Leber, DW Andrews
Biochimica et Biophysica Acta (BBA)-Molecular Cell Research 1813 (4), 508-520, 2011
5192011
Bcl-2 and Bax regulate the channel activity of the mitochondrial adenine nucleotide translocator
C Brenner, H Cadiou, HLA Vieira, N Zamzami, I Marzo, Z Xie, B Leber, ...
Oncogene 19 (3), 329-336, 2000
5122000
Embedded together: the life and death consequences of interaction of the Bcl-2 family with membranes
B Leber, J Lin, DW Andrews
Apoptosis 12, 897-911, 2007
4722007
Bax forms multispanning monomers that oligomerize to permeabilize membranes during apoptosis
MG Annis, EL Soucie, PJ Dlugosz, JA Cruz‐Aguado, LZ Penn, B Leber, ...
The EMBO journal 24 (12), 2096-2103, 2005
4722005
Bcl‐2 mutants with restricted subcellular location reveal spatially distinct pathways for apoptosis in different cell types.
W Zhu, A Cowie, GW Wasfy, LZ Penn, B Leber, DW Andrews
The EMBO journal 15 (16), 4130-4141, 1996
4311996
Bcl-XL inhibits membrane permeabilization by competing with Bax
LP Billen, CL Kokoski, JF Lovell, B Leber, DW Andrews
PLoS biology 6 (6), e147, 2008
3852008
Long-term outcome of a pediatric-inspired regimen used for adults aged 18–50 years with newly diagnosed acute lymphoblastic leukemia
DJ DeAngelo, KE Stevenson, SE Dahlberg, LB Silverman, S Couban, ...
Leukemia 29 (3), 526-534, 2015
3412015
Molecular targeting of the oncogene eIF4E in acute myeloid leukemia (AML): a proof-of-principle clinical trial with ribavirin
S Assouline, B Culjkovic, E Cocolakis, C Rousseau, N Beslu, A Amri, ...
Blood 114 (2), 257-260, 2009
3412009
Bcl‐2 changes conformation to inhibit Bax oligomerization
PJ Dlugosz, LP Billen, MG Annis, W Zhu, Z Zhang, J Lin, B Leber, ...
The EMBO journal 25 (11), 2287-2296, 2006
3372006
Five new pedigrees with inherited RUNX1 mutations causing familial platelet disorder with propensity to myeloid malignancy
CJ Owen, CL Toze, A Koochin, DL Forrest, CA Smith, JM Stevens, ...
Blood, The Journal of the American Society of Hematology 112 (12), 4639-4645, 2008
2872008
Interaction with a membrane surface triggers a reversible conformational change in Bax normally associated with induction of apoptosis
JA Yethon, RF Epand, B Leber, RM Epand, DW Andrews
Journal of Biological Chemistry 278 (49), 48935-48941, 2003
2442003
Campath-1H treatment of T-cell prolymphocytic leukemia in patients for whom at least one prior chemotherapy regimen has failed
MJ Keating, B Cazin, S Coutre, R Birhiray, T Kovacsovics, W Langer, ...
Journal of Clinical Oncology 20 (1), 205-213, 2002
2442002
Still embedded together binding to membranes regulates Bcl-2 protein interactions
B Leber, J Lin, DW Andrews
Oncogene 29 (38), 5221-5230, 2010
2092010
The sonic hedgehog factor GLI1 imparts drug resistance through inducible glucuronidation
HA Zahreddine, B Culjkovic-Kraljacic, S Assouline, P Gendron, ...
Nature 511 (7507), 90-93, 2014
2032014
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