Chemical proteomics identifies druggable vulnerabilities in a genetically defined cancer L Bar-Peled, EK Kemper, RM Suciu, EV Vinogradova, KM Backus, ... Cell 171 (3), 696-709. e23, 2017 | 221 | 2017 |
An activity-guided map of electrophile-cysteine interactions in primary human T cells EV Vinogradova, X Zhang, D Remillard, DC Lazar, RM Suciu, Y Wang, ... Cell 182 (4), 1009-1026. e29, 2020 | 218 | 2020 |
Notum produced by Paneth cells attenuates regeneration of aged intestinal epithelium N Pentinmikko, S Iqbal, M Mana, S Andersson, AB Cognetta, RM Suciu, ... Nature 571 (7765), 398-402, 2019 | 196 | 2019 |
A proteome-wide atlas of lysine-reactive chemistry ME Abbasov, ME Kavanagh, TA Ichu, MR Lazear, Y Tao, VM Crowley, ... Nature Chemistry 13 (11), 1081-1092, 2021 | 121 | 2021 |
A Pan-ALDH1A Inhibitor Induces Necroptosis in Ovarian Cancer Stem-like Cells I Chefetz, E Grimley, K Yang, L Hong, EV Vinogradova, R Suciu, ... Cell Reports 26 (11), 3061-3075. e6, 2019 | 118 | 2019 |
Chemical Proteomic Profiling of Human Methyltransferases BD Horning, RM Suciu, DA Ghadiri, OA Ulanovskaya, ML Matthews, ... Journal of the American Chemical Society, 2016 | 89 | 2016 |
2-Sulfonylpyridines as Tunable, Cysteine-Reactive Electrophiles C Zambaldo, EV Vinogradova, X Qi, J Iaconelli, RM Suciu, M Koh, ... Journal of the American Chemical Society 142 (19), 8972-8979, 2020 | 73 | 2020 |
Direct Access to Versatile Electrophiles via Catalytic Oxidative Cyanation of Alkenes DW Gao, EV Vinogradova, SK Nimmagadda, JM Medina, Y Xiao, ... Journal of the American Chemical Society, 2018 | 66 | 2018 |
Dimethyl Fumarate Disrupts Human Innate Immune Signaling by Targeting the IRAK4–MyD88 Complex BW Zaro, EV Vinogradova, DC Lazar, MM Blewett, RM Suciu, J Takaya, ... The Journal of Immunology 202 (9), 2737-2746, 2019 | 55 | 2019 |
ABHD17 regulation of plasma membrane palmitoylation and N-Ras-dependent cancer growth JR Remsberg, RM Suciu, NA Zambetti, TW Hanigan, AJ Firestone, ... Nature Chemical Biology, 1-9, 2021 | 51 | 2021 |
Single-Cell Profiling and SCOPE-Seq Reveal Lineage Dynamics of Adult Ventricular-Subventricular Zone Neurogenesis and NOTUM as a Key Regulator D Mizrak, NS Bayin, J Yuan, Z Liu, RM Suciu, MJ Niphakis, N Ngo, ... Cell Reports 31 (12), 107805, 2020 | 48 | 2020 |
Selective Irreversible Inhibitors of the Wnt-Deacylating Enzyme NOTUM Developed by Activity-Based Protein Profiling RM Suciu, AB Cognetta III, ZE Potter, BF Cravatt ACS Medicinal Chemistry Letters, 2018 | 44 | 2018 |
The proteome‐wide potential for reversible covalency at cysteine K Senkane, EV Vinogradova, RM Suciu, VM Crowley, BW Zaro, ... Angewandte Chemie 131 (33), 11507-11511, 2019 | 43 | 2019 |
Activity-Based Hydrazine Probes for Protein Profiling of Electrophilic Functionality in Therapeutic Targets Z Lin, X Wang, KA Bustin, K Shishikura, NR McKnight, L He, RM Suciu, ... ACS central science 7 (9), 1524-1534, 2021 | 23 | 2021 |
Covalent inhibitors of nicotinamide N-methyltransferase (NNMT) provide evidence for target engagement challenges in situ HY Lee, RM Suciu, BD Horning, EV Vinogradova, OA Ulanovskaya, ... Bioorganic & Medicinal Chemistry Letters, 2018 | 21 | 2018 |
Genetic disruption of N-RasG12D palmitoylation perturbs hematopoiesis and prevents myeloid transformation in mice NA Zambetti, AJ Firestone, JR Remsberg, BJ Huang, JC Wong, AM Long, ... Blood 135 (20), 1772-1782, 2020 | 15 | 2020 |
A chemical proteomic probe for the mitochondrial pyruvate carrier complex Y Yamashita, EV Vinogradova, X Zhang, RM Suciu, BF Cravatt Angewandte Chemie 132 (10), 3924-3927, 2020 | 12 | 2020 |
Chemical proteomic identification of functional cysteines with atypical electrophile reactivities K Litwin, VM Crowley, RM Suciu, DL Boger, BF Cravatt Tetrahedron Letters 67, 152861, 2021 | 9 | 2021 |
GeneDig: a web application for accessing genomic and bioinformatics knowledge RM Suciu, E Aydin, BE Chen BMC Bioinformatics 16 (1), 67, 2015 | 6 | 2015 |
Chemical proteomic analysis of palmostatin beta-lactone analogs that affect N-Ras palmitoylation RM Suciu, IK Luvaga, A Hazeen, C Weerasooriya, SK Richardson, ... Bioorganic & Medicinal Chemistry Letters 53, 128414, 2021 | 3 | 2021 |