Segui
Jun Wan Shin
Jun Wan Shin
Department of Neurology, Harvard Medical School and Center for Human Genetic Research, MGH
Email verificata su mgh.harvard.edu
Titolo
Citata da
Citata da
Anno
Permanent inactivation of Huntington's disease mutation by personalized allele-specific CRISPR/Cas9
JW Shin, KH Kim, MJ Chao, RS Atwal, T Gillis, ME MacDonald, JF Gusella, ...
Human molecular genetics 25 (20), 4566-4576, 2016
2912016
Nitric oxide induces expression of cyclooxygenase-2 in mouse skin through activation of NF-κB
KS Chun, HH Cha, JW Shin, HK Na, KK Park, WY Chung, YJ Surh
Carcinogenesis 25 (3), 445-454, 2004
1532004
Antitumor promotional effects of a novel intestinal bacterial metabolite (IH-901) derived from the protopanaxadiol-type ginsenosides in mouse skin
JY Lee, JW Shin, KS Chun, KK Park, WY Chung, YJ Bang, JH Sung, ...
Carcinogenesis 26 (2), 359-367, 2005
1282005
Curcumin induces stabilization of Nrf2 protein through Keap1 cysteine modification
JW Shin, KS Chun, DH Kim, SJ Kim, SH Kim, NC Cho, HK Na, YJ Surh
Biochemical Pharmacology 173, 113820, 2020
1052020
Zerumbone induces heme oxygenase-1 expression in mouse skin and cultured murine epidermal cells through activation of Nrf2
JW Shin, K Ohnishi, A Murakami, JS Lee, JK Kundu, HK Na, H Ohigashi, ...
Cancer prevention research 4 (6), 860-870, 2011
792011
cis- 9, trans- 11-Conjugated linoleic acid down-regulates phorbol ester-induced NF-κB activation and subsequent COX-2 expression in …
DM Hwang, JK Kundu, JW Shin, JC Lee, HJ Lee, YJ Surh
Carcinogenesis 28 (2), 363-371, 2007
722007
Docosahexaenoic acid inhibits UVB-induced activation of NF-κB and expression of COX-2 and NOX-4 in HR-1 hairless mouse skin by blocking MSK1 signaling
MM Rahman, JK Kundu, JW Shin, HK Na, YJ Surh
Plos one 6 (11), e28065, 2011
602011
Thymoquinone inhibits phorbol ester-induced activation of NF-κB and expression of COX-2, and induces expression of cytoprotective enzymes in mouse skin in vivo
JK Kundu, L Liu, JW Shin, YJ Surh
Biochemical and biophysical research communications 438 (4), 721-727, 2013
582013
Genetic and functional analyses point to FAN1 as the source of multiple Huntington disease modifier effects
KH Kim, EP Hong, JW Shin, MJ Chao, J Loupe, T Gillis, JS Mysore, ...
The American Journal of Human Genetics 107 (1), 96-110, 2020
492020
Population-specific genetic modification of Huntington's disease in Venezuela
MJ Chao, KH Kim, JW Shin, D Lucente, VC Wheeler, H Li, JC Roach, ...
PLoS genetics 14 (5), e1007274, 2018
332018
Ultraviolet B radiation activates NF‐κB and induces iNOS expression in HR‐1 hairless mouse skin: Role of IκB kinase‐β
EJ Chang, JK Kundu, L Liu, JW Shin, YJ Surh
Molecular Carcinogenesis 50 (4), 310-317, 2011
332011
Phloretin inhibits phorbol ester–induced tumor promotion and expression of cyclooxygenase-2 in mouse skin: extracellular signal-regulated kinase and nuclear factor-κB as …
JW Shin, JK Kundu, YJ Surh
Journal of medicinal food 15 (3), 253-257, 2012
232012
Endogenous ω-3 Fatty Acid Production by fat-1 Transgene and Topically Applied Docosahexaenoic Acid Protect against UVB-induced Mouse Skin Carcinogenesis
HW Yum, J Park, HJ Park, JW Shin, YY Cho, SJ Kim, JX Kang, YJ Surh
Scientific Reports 7 (1), 11658, 2017
212017
The prospects of CRISPR-based genome engineering in the treatment of neurodegenerative disorders
JW Shin, JM Lee
Therapeutic advances in neurological disorders 11, 1756285617741837, 2018
202018
Protein tyrosine phosphatases PTP-1B, SHP-2, and PTEN facilitate Rb/E2F-associated apoptotic signaling
LD Morales, EA Casillas Pavón, JW Shin, A Garcia, M Capetillo, DJ Kim, ...
PLoS One 9 (5), e97104, 2014
172014
Novel allele-specific quantification methods reveal no effects of adult onset CAG repeats on HTT mRNA and protein levels
A Shin, B Shin, JW Shin, KH Kim, RS Atwal, JM Hope, T Gillis, JD Leszyk, ...
Human Molecular Genetics 26 (7), 1258-1267, 2017
152017
Allele-specific silencing of the gain-of-function mutation in Huntington’s disease using CRISPR/Cas9
JW Shin, EP Hong, SS Park, DE Choi, IS Seong, MN Whittaker, ...
JCI insight 7 (19), 2022
112022
PAM-altering SNP-based allele-specific CRISPR-Cas9 therapeutic strategies for Huntington’s disease
JW Shin, EP Hong, SS Park, DE Choi, S Zeng, RZ Chen, JM Lee
Molecular Therapy-Methods & Clinical Development 26, 547-561, 2022
62022
Haplotype-specific insertion-deletion variations for allele-specific targeting in Huntington's disease
JW Shin, A Shin, SS Park, JM Lee
Molecular Therapy-Methods & Clinical Development 25, 84-95, 2022
62022
Full sequence of mutant huntingtin 3′-untranslated region and modulation of its gene regulatory activity by endogenous microRNA
KH Kim, K Abu Elneel, JW Shin, JW Keum, D Seong, S Kwak, R Lee, ...
Journal of human genetics 64 (10), 995-1004, 2019
62019
Il sistema al momento non può eseguire l'operazione. Riprova più tardi.
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