Advancing therapeutic protein discovery and development through comprehensive computational and biophysical characterization L Gentiluomo, HL Svilenov, D Augustijn, I El Bialy, ML Greco, A Kulakova, ... Molecular Pharmaceutics 17 (2), 426-440, 2019 | 43 | 2019 |
Surface-catalyzed secondary nucleation dominates the generation of toxic IAPP aggregates DC Rodriguez Camargo, S Chia, J Menzies, B Mannini, G Meisl, ... Frontiers in Molecular Biosciences 8, 1037, 2021 | 23 | 2021 |
Conformational stability study of a therapeutic peptide plectasin using molecular dynamics simulations in combination with NMR S Indrakumar, M Zalar, C Pohl, A Nørgaard, W Streicher, P Harris, ... The Journal of Physical Chemistry B 123 (23), 4867-4877, 2019 | 16 | 2019 |
The Effect of Point Mutations on the Biophysical Properties of an Antimicrobial Peptide: Development of a Screening Protocol for Peptide Stability Screening C Pohl, M Zalar, IE Bialy, S Indrakumar, GHJ Peters, W Friess, ... Molecular Pharmaceutics 17 (9), 3298-3313, 2020 | 11 | 2020 |
pH-and concentration-dependent supramolecular assembly of a fungal defensin plectasin variant into helical non-amyloid fibrils C Pohl, G Effantin, E Kandiah, S Meier, G Zeng, W Streicher, DR Segura, ... Nature Communications 13 (1), 3162, 2022 | 10 | 2022 |
Novel non-linear curve fitting to resolve protein unfolding transitions in intrinsic fluorescence differential scanning fluorimetry D Augustijn, S Mahapatra, W Streicher, H Svilenov, A Kulakova, C Pohl, ... European Journal of Pharmaceutics and Biopharmaceutics 142, 506-517, 2019 | 7 | 2019 |
Electrostatics drive oligomerization and aggregation of human interferon alpha-2a C Pohl, M Polimeni, S Indrakumar, W Streicher, GHJ Peters, A Nørgaard, ... The Journal of Physical Chemistry B 125 (50), 13657-13669, 2021 | 6 | 2021 |
Combination of high throughput and structural screening to assess protein stability–A screening perspective C Pohl, S Mahapatra, A Kulakova, W Streicher, GHJ Peters, A Nørgaard, ... European Journal of Pharmaceutics and Biopharmaceutics 171, 1-10, 2022 | 5 | 2022 |
Development of a fast screening method for selecting excipients in formulations using MD simulations, NMR and microscale thermophoresis S Indrakumar, M Zalar, N Tschammer, C Pohl, A Nørgaard, W Streicher, ... European Journal of Pharmaceutics and Biopharmaceutics 158, 11-20, 2021 | 5 | 2021 |
Chemometrics in Protein Formulation: Stability Governed by Repulsion and Protein Unfolding A Kulakova, D Augustijn, I El Bialy, L Gentiluomo, ML Greco, ... Molecular Pharmaceutics 20 (6), 2951-2965, 2023 | | 2023 |
Reversible supramolecular assembly of the anti-microbial peptide plectasin into helical non-amyloid fibrils C Pohl, G Effantin, E Kandiah, S Meier, G Zeng, W Streicher, GHJ Peters, ... bioRxiv, 2021.09. 06.458672, 2021 | | 2021 |
Characterization of protein-protein interaction of single domain proteins in solution CA Pohl Technical University of Denmark, 2020 | | 2020 |