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Sachin Gajghate
Sachin Gajghate
Spark Therapeutics
Verified email at sparktx.com
Title
Cited by
Cited by
Year
Exposure to electronic cigarettes impairs pulmonary anti-bacterial and anti-viral defenses in a mouse model
TE Sussan, S Gajghate, RK Thimmulappa, J Ma, JH Kim, K Sudini, ...
PloS one 10 (2), e0116861, 2015
4662015
Small molecule inhibitor of NRF2 selectively intervenes therapeutic resistance in KEAP1-deficient NSCLC tumors
A Singh, S Venkannagari, KH Oh, YQ Zhang, JM Rohde, L Liu, ...
ACS chemical biology 11 (11), 3214-3225, 2016
4382016
Hyperglycemia-driven neuroinflammation compromises BBB leading to memory loss in both diabetes mellitus (DM) type 1 and type 2 mouse models
S Rom, V Zuluaga-Ramirez, S Gajghate, A Seliga, M Winfield, NA Heldt, ...
Molecular neurobiology 56, 1883-1896, 2019
2302019
miR-98 reduces endothelial dysfunction by protecting blood–brain barrier (BBB) and improves neurological outcomes in mouse ischemia/reperfusion stroke model
DL Bernstein, V Zuluaga-Ramirez, S Gajghate, NL Reichenbach, ...
Journal of Cerebral Blood Flow & Metabolism 40 (10), 1953-1965, 2020
982020
Cited2 modulates hypoxia‐inducible factor–dependent expression of vascular endothelial growth factor in nucleus pulposus cells of the rat intervertebral disc
A Agrawal, S Gajghate, H Smith, DG Anderson, TJ Albert, IM Shapiro, ...
Arthritis & Rheumatism: Official Journal of the American College of …, 2008
942008
PI3K/AKT regulates aggrecan gene expression by modulating Sox9 expression and activity in nucleus pulposus cells of the intervertebral disc
CC Cheng, Y Uchiyama, A Hiyama, S Gajghate, IM Shapiro, MV Risbud
Journal of cellular physiology 221 (3), 668-676, 2009
932009
Nrf2 reduces allergic asthma in mice through enhanced airway epithelial cytoprotective function
TE Sussan, S Gajghate, S Chatterjee, P Mandke, S McCormick, K Sudini, ...
American Journal of Physiology-Lung Cellular and Molecular Physiology 309 (1 …, 2015
842015
Antiinflammatory role of MUC1 mucin during infection with nontypeable Haemophilus influenzae.
KKC Kyo Y1, Kato K, Park YS, Gajghate S, Umehara T, Lillehoj EP, Suzaki H
Am J Respir Cell Mol Biol 46 (2), 149-56, 2012
812012
BMP‐2 and TGF‐β stimulate expression of β1, 3‐glucuronosyl transferase 1 (GlcAT‐1) in nucleus pulposus cells through AP1, TonEBP, and Sp1: Role of MAPKs
A Hiyama, SS Gogate, S Gajghate, J Mochida, IM Shapiro, MV Risbud
Journal of Bone and Mineral Research 25 (5), 1179-1190, 2010
782010
Hyperglycemia and advanced glycation end products disrupt BBB and promote occludin and claudin-5 protein secretion on extracellular microvesicles
S Rom, NA Heldt, S Gajghate, A Seliga, NL Reichenbach, Y Persidsky
Scientific reports 10 (1), 7274, 2020
762020
Osmolarity and intracellular calcium regulate aquaporin2 expression through TonEBP in nucleus pulposus cells of the intervertebral disc
S Gajghate, A Hiyama, M Shah, D Sakai, DG Anderson, IM Shapiro, ...
Journal of Bone and Mineral Research 24 (6), 992-1001, 2009
692009
Activation of TonEBP by calcium controls β1, 3-glucuronosyltransferase-I expression, a key regulator of glycosaminoglycan synthesis in cells of the intervertebral disc
A Hiyama, S Gajghate, D Sakai, J Mochida, IM Shapiro, MV Risbud
Journal of biological chemistry 284 (15), 9824-9834, 2009
592009
Activation of GPR55 induces neuroprotection of hippocampal neurogenesis and immune responses of neural stem cells following chronic, systemic inflammation
JD Hill, V Zuluaga-Ramirez, S Gajghate, M Winfield, U Sriram, S Rom, ...
Brain, behavior, and immunity 76, 165-181, 2019
542019
Activation of GPR55 increases neural stem cell proliferation and promotes early adult hippocampal neurogenesis
JD Hill, V Zuluaga‐Ramirez, S Gajghate, M Winfield, Y Persidsky
British journal of pharmacology 175 (16), 3407-3421, 2018
432018
Electronic cigarette exposure disrupts blood-brain barrier integrity and promotes neuroinflammation
NA Heldt, A Seliga, M Winfield, S Gajghate, N Reichenbach, X Yu, S Rom, ...
Brain, behavior, and immunity 88, 363-380, 2020
412020
PARP inhibition in leukocytes diminishes inflammation via effects on integrins/cytoskeleton and protects the blood-brain barrier
S Rom, V Zuluaga-Ramirez, NL Reichenbach, H Dykstra, S Gajghate, ...
Journal of Neuroinflammation 13, 1-16, 2016
402016
SMAD3 functions as a transcriptional repressor of acid‐sensing ion channel 3 (ASIC3) in nucleus pulposus cells of the intervertebral disc
Y Uchiyama, A Guttapalli, S Gajghate, J Mochida, IM Shapiro, MV Risbud
Journal of Bone and Mineral Research 23 (10), 1619-1628, 2008
392008
Secoisolariciresinol diglucoside is a blood-brain barrier protective and anti-inflammatory agent: implications for neuroinflammation
S Rom, V Zuluaga-Ramirez, NL Reichenbach, MA Erickson, M Winfield, ...
Journal of Neuroinflammation 15, 1-10, 2018
382018
let-7g counteracts endothelial dysfunction and ameliorating neurological functions in mouse ischemia/reperfusion stroke model
DL Bernstein, S Gajghate, NL Reichenbach, M Winfield, Y Persidsky, ...
Brain, behavior, and immunity 87, 543-555, 2020
222020
Chronic intrahippocampal infusion of HIV-1 neurotoxic proteins: a novel mouse model of HIV-1 associated inflammation and neural stem cell dysfunction
JD Hill, V Zuluaga-Ramirez, S Gajghate, M Winfield, Y Persidsky
Journal of NeuroImmune Pharmacology 14, 375-382, 2019
92019
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