A saturation mutagenesis approach to understanding PTEN lipid phosphatase activity and genotype-phenotype relationships TL Mighell, S Evans-Dutson, BJ O’Roak The American Journal of Human Genetics 102 (5), 943-955, 2018 | 175 | 2018 |
AAV-mediated CRISPR/Cas9 gene editing in murine phenylketonuria DY Richards, SR Winn, S Dudley, S Nygaard, TL Mighell, M Grompe, ... Molecular Therapy-Methods & Clinical Development 17, 234-245, 2020 | 77 | 2020 |
An integrated deep-mutational-scanning approach provides clinical insights on PTEN genotype-phenotype relationships TL Mighell, S Thacker, E Fombonne, C Eng, BJ O’Roak The American Journal of Human Genetics 106 (6), 818-829, 2020 | 38 | 2020 |
A sort-seq approach to the development of single fluorescent protein biosensors JN Koberstein, ML Stewart, TL Mighell, CB Smith, MS Cohen ACS chemical biology 16 (9), 1709-1720, 2021 | 13 | 2021 |
SUNi mutagenesis: Scalable and uniform nicking for efficient generation of variant libraries TL Mighell, I Toledano, B Lehner Plos one 18 (7), e0288158, 2023 | 1 | 2023 |
Crispr-mediated capture of nucleic acids BJ O'roak, A Andrew, T Mighell, R Mulqueen, C Thornton US Patent App. 17/753,592, 2022 | | 2022 |
Cas12a-Capture: a novel, low-cost, and scalable method for targeted sequencing TL Mighell, A Nishida, BL O'connell, CV Miller, S Grindstaff, CA Thornton, ... The CRISPR Journal 5 (4), 548-557, 2022 | | 2022 |