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Mahesh Hegde
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Quercetin, a Natural Flavonoid Interacts with DNA, Arrests Cell Cycle and Causes Tumor Regression by Activating Mitochondrial Pathway of Apoptosis
S Srivastava, RR Somasagara, M Hegde, M Nishana, SK Tadi, ...
Scientific reports 6, 2016
5042016
An inhibitor of nonhomologous end-joining abrogates double-strand break repair and impedes cancer progression
M Srivastava, M Nambiar, S Sharma, SS Karki, G Goldsmith, M Hegde, ...
Cell 151 (7), 1474-1487, 2012
4152012
Extracts of strawberry fruits induce intrinsic pathway of apoptosis in breast cancer cells and inhibits tumor progression in mice
RR Somasagara, M Hegde, KK Chiruvella, A Musini, B Choudhary, ...
Public Library of Science 7 (10), e47021, 2012
1202012
CBFβ-SMMHC inhibition triggers apoptosis by disrupting MYC chromatin dynamics in acute myeloid leukemia
JA Pulikkan, M Hegde, HM Ahmad, H Belaghzal, A Illendula, J Yu, ...
Cell 174 (1), 172-186. e21, 2018
842018
A Novel Resveratrol Based Tubulin Inhibitor Induces Mitotic Arrest and Activates Apoptosis in Cancer Cells
E Thomas, V Gopalakrishnan, M Hegde, S Kumar, SS Karki, ...
Scientific reports 6, 2016
722016
Sapodilla Plum (Achras sapota) Induces Apoptosis in Cancer Cell Lines and Inhibits Tumor Progression in Mice
M Srivastava, M Hegde, KK Chiruvella, J Koroth, S Bhattacharya, ...
Scientific reports 4 (1), 6147, 2014
702014
Synthesis and antiproliferative effect of novel 4-thiazolidinone-, pyridine-and piperazine-based conjugates on human leukemic cells
KSS Kumar, A Hanumappa, M Hegde, KH Narasimhamurthy, ...
European Journal of Medicinal Chemistry 81, 341-349, 2014
632014
Novel levamisole derivative induces extrinsic pathway of apoptosis in cancer cells and inhibits tumor progression in mice
M Hegde, SS Karki, E Thomas, S Kumar, K Panjamurthy, SR Ranganatha, ...
Public Library of Science 7 (9), e43632, 2012
632012
Antiproliferative and tumor inhibitory studies of 2, 3 disubstituted 4-thiazolidinone derivatives
KSS Kumar, A Hanumappa, M Vetrivel, M Hegde, YR Girish, ...
Bioorganic & medicinal chemistry letters 25 (17), 3616-3620, 2015
622015
Identification of a novel BCL2‐specific inhibitor that binds predominantly to the BH1 domain
D Iyer, SV Vartak, A Mishra, G Goldsmith, S Kumar, M Srivastava, ...
The FEBS Journal 283 (18), 3408-37, 2016
482016
A novel benzimidazole derivative binds to the DNA minor groove and induces apoptosis in leukemic cells
M Hegde, KSS Kumar, E Thomas, H Ananda, SC Raghavan, ...
RSC advances 5 (113), 93194-93208, 2015
462015
Synthesis and antiproliferative activity of imidazo [2, 1-b][1, 3, 4] thiadiazole derivatives
S Kumar, V Gopalakrishnan, M Hegde, V Rana, SS Dhepe, ...
Bioorganic & Medicinal Chemistry Letters 24 (19), 4682-4688, 2014
372014
2-(4-Chlorobenzyl)-6-arylimidazo [2, 1-b][1, 3, 4] thiadiazoles: synthesis, cytotoxic activity and mechanism of action
M Hegde, S Kumar, V Gopalakrishnan, VK Renuka, SA Ramareddy, ...
European journal of medicinal chemistry 84, 687-697, 2014
362014
Induction of apoptosis and downregulation of ERα in DMBA-induced mammary gland tumors in Sprague–Dawley rats by synthetic 3, 5-disubstituted isoxazole derivatives
H Ananda, KSS Kumar, M Hegde, KS Rangappa
Molecular and Cellular Biochemistry 420 (1-2), 141-50, 2016
332016
Induction of apoptosis and downregulation of ERα in DMBA-induced mammary gland tumors in Sprague–Dawley rats by synthetic 3,5-disubstituted isoxazole derivatives
H Ananda, KS Sharath Kumar, M Hegde, KS Rangappa
Molecular and Cellular Biochemistry 420 (1-2), 141-150, 2016
332016
Regioselective synthesis and biological studies of novel 1-aryl-3, 5-bis (het) aryl pyrazole derivatives as potential antiproliferative agents
H Ananda, KS Sharath Kumar, M Nishana, M Hegde, M Srivastava, ...
Molecular and cellular biochemistry 426, 149-160, 2017
322017
Platelet protective efficacy of 3,4,5 trisubstituted isoxazoles analogue by inhibiting ros-mediated apoptosis and platelet aggregation
KSR Jagadish Das, Narasimhamurthy Rajeev, Somanathapura K. NaveenKumar ...
Molecular and Cellular Biochemistry 414 (1-2), 137-51, 2016
302016
A novel inhibitor of BCL2, Disarib abrogates tumor growth while sparing platelets, by activating intrinsic pathway of apoptosis
M Hegde, SV Vartak, D Iyer, S Gaikwad, V Gopalakrishnan, M Srivastava, ...
Biochemical Pharmacology, 2016
272016
Synthesis and evaluation of the biological activity of N′-[2-oxo-1, 2 dihydro-3 H-indol-3-ylidene] benzohydrazides as potential anticancer agents
M Hegde, A Katiyar, S Kumar, V Gopalakrishnan, KD Bhatelia, ...
RSC Advances 5 (56), 45492-45501, 2015
252015
A benzothiazole derivative (5g) induces DNA damage and potent G2/M arrest in cancer cells
M Hegde, SV Vartak, CV Kavitha, H Ananda, DS Prasanna, ...
Scientific Reports 7 (1), 2533, 2017
242017
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