| Heterotrimeric G protein activation by G-protein-coupled receptors WM Oldham, HE Hamm Nature reviews Molecular cell biology 9 (1), 60-71, 2008 | 1568 | 2008 |
| Vascular stiffness mechanoactivates YAP/TAZ-dependent glutaminolysis to drive pulmonary hypertension T Bertero, WM Oldham, KA Cottrill, S Pisano, RR Vanderpool, Q Yu, ... The Journal of clinical investigation 126 (9), 3313-3335, 2016 | 354 | 2016 |
| Structural basis of function in heterotrimeric G proteins WM Oldham, HE Hamm Quarterly reviews of biophysics 39 (2), 117-166, 2006 | 342 | 2006 |
| Hypoxia-mediated increases in L-2-hydroxyglutarate coordinate the metabolic response to reductive stress WM Oldham, CB Clish, Y Yang, J Loscalzo Cell metabolism 22 (2), 291-303, 2015 | 320 | 2015 |
| Tumor-stroma mechanics coordinate amino acid availability to sustain tumor growth and malignancy T Bertero, WM Oldham, EM Grasset, I Bourget, E Boulter, S Pisano, ... Cell metabolism 29 (1), 124-140. e10, 2019 | 269 | 2019 |
| Mechanism of the receptor-catalyzed activation of heterotrimeric G proteins WM Oldham, N Van Eps, AM Preininger, WL Hubbell, HE Hamm Nature structural & molecular biology 13 (9), 772-777, 2006 | 232 | 2006 |
| Targeting immunosuppressive macrophages overcomes PARP inhibitor resistance in BRCA1-associated triple-negative breast cancer AK Mehta, EM Cheney, CA Hartl, C Pantelidou, M Oliwa, JA Castrillon, ... Nature cancer 2 (1), 66-82, 2021 | 142 | 2021 |
| How do receptors activate G proteins? WM Oldham, HE Hamm Advances in protein chemistry 74, 67-93, 2007 | 110 | 2007 |
| NEDD9 targets COL3A1 to promote endothelial fibrosis and pulmonary arterial hypertension AO Samokhin, T Stephens, BM Wertheim, RS Wang, SO Vargas, LM Yung, ... Science translational medicine 10 (445), eaap7294, 2018 | 105 | 2018 |
| Structural and dynamical changes in an α-subunit of a heterotrimeric G protein along the activation pathway N Van Eps, WM Oldham, HE Hamm, WL Hubbell Proceedings of the National Academy of Sciences 103 (44), 16194-16199, 2006 | 99 | 2006 |
| Mapping allosteric connections from the receptor to the nucleotide-binding pocket of heterotrimeric G proteins WM Oldham, N Van Eps, AM Preininger, WL Hubbell, HE Hamm Proceedings of the National Academy of Sciences 104 (19), 7927-7932, 2007 | 87 | 2007 |
| Protocol for exercise hemodynamic assessment: performing an invasive cardiopulmonary exercise test in clinical practice NC Berry, A Manyoo, WM Oldham, TE Stephens, RH Goldstein, ... Pulmonary circulation 5 (4), 610-618, 2015 | 81 | 2015 |
| Mechano-induced cell metabolism promotes microtubule glutamylation to force metastasis S Torrino, EM Grasset, S Audebert, I Belhadj, C Lacoux, M Haynes, ... Cell Metabolism 33 (7), 1342-1357. e10, 2021 | 72 | 2021 |
| Unexplained exertional dyspnea caused by low ventricular filling pressures: results from clinical invasive cardiopulmonary exercise testing WM Oldham, GD Lewis, AR Opotowsky, AB Waxman, DM Systrom Pulmonary circulation 6 (1), 55-62, 2016 | 72 | 2016 |
| Upregulation of steroidogenic acute regulatory protein by hypoxia stimulates aldosterone synthesis in pulmonary artery endothelial cells to promote pulmonary vascular fibrosis BA Maron, WM Oldham, SY Chan, SO Vargas, E Arons, YY Zhang, ... Circulation 130 (2), 168-179, 2014 | 64 | 2014 |
| Metabolic regulation of species-specific developmental rates M Diaz-Cuadros, TP Miettinen, OS Skinner, D Sheedy, CM Díaz-García, ... Nature 613 (7944), 550-557, 2023 | 63 | 2023 |
| Reaction rate of pyruvate and hydrogen peroxide: assessing antioxidant capacity of pyruvate under biological conditions VA Guarino, WM Oldham, J Loscalzo, YY Zhang Scientific reports 9 (1), 19568, 2019 | 63 | 2019 |
| Gβγ activates GSK3 to promote LRP6-mediated β-catenin transcriptional activity KK Jernigan, CS Cselenyi, CA Thorne, AJ Hanson, E Tahinci, N Hajicek, ... Science signaling 3 (121), ra37-ra37, 2010 | 61 | 2010 |
| Individualized interactomes for network-based precision medicine in hypertrophic cardiomyopathy with implications for other clinical pathophenotypes BA Maron, RS Wang, S Shevtsov, SG Drakos, E Arons, O Wever-Pinzon, ... Nature communications 12 (1), 873, 2021 | 57 | 2021 |
| p62/SQSTM1 cooperates with hyperactive mTORC1 to regulate glutathione production, maintain mitochondrial integrity, and promote tumorigenesis HC Lam, CV Baglini, AL Lope, AA Parkhitko, HJ Liu, N Alesi, ... Cancer research 77 (12), 3255-3267, 2017 | 55 | 2017 |
heidi hammProfessor of PharmacologyVerified email at vanderbilt.edu
