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Nikhil Nitin Kulkarni
Nikhil Nitin Kulkarni
Scientist, Takeda Pharmaceuticals
Verified email at takeda.com
Title
Cited by
Cited by
Year
Cathelicidin promotes inflammation by enabling binding of self-RNA to cell surface scavenger receptors
T Takahashi, NN Kulkarni, EY Lee, L Zhang, GCL Wong, RL Gallo
Scientific reports 8 (1), 4032, 2018
742018
Phenylbutyrate induces cathelicidin expression via the vitamin D receptor: Linkage to inflammatory and growth factor cytokines pathways
NN Kulkarni, Z Yi, C Huehnken, B Agerberth, GH Gudmundsson
Molecular immunology 63 (2), 530-539, 2015
622015
Innate immune dysfunction in rosacea promotes photosensitivity and vascular adhesion molecule expression
NN Kulkarni, T Takahashi, JA Sanford, Y Tong, AF Gombart, B Hinds, ...
Journal of Investigative Dermatology 140 (3), 645-655. e6, 2020
432020
Bordetella pertussis adenylate cyclase toxin disrupts functional integrity of bronchial epithelial layers
S Hasan, NN Kulkarni, A Asbjarnarson, I Linhartova, R Osicka, P Sebo, ...
Infection and immunity 86 (3), 10.1128/iai. 00445-17, 2018
432018
Cutaneous innate immune tolerance is mediated by epigenetic control of MAP2K3 by HDAC8/9
Y Sawada, T Nakatsuji, T Dokoshi, NN Kulkarni, MC Liggins, G Sen, ...
Science immunology 6 (59), eabe1935, 2021
362021
Glucocorticoid dexamethasone down-regulates basal and vitamin D3 induced cathelicidin expression in human monocytes and bronchial epithelial cell line
NN Kulkarni, HI Gunnarsson, Z Yi, S Gudmundsdottir, OE Sigurjonsson, ...
Immunobiology 221 (2), 245-252, 2016
272016
IL-1 receptor–knockout mice develop epidermal cysts and show an altered innate immune response after exposure to UVB radiation
NN Kulkarni, CA Adase, L Zhang, AW Borkowski, F Li, JA Sanford, ...
Journal of Investigative Dermatology 137 (11), 2417-2426, 2017
182017
Cyclic mechanical stretch down-regulates cathelicidin antimicrobial peptide expression and activates a pro-inflammatory response in human bronchial epithelial cells
H Karadottir, NN Kulkarni, T Gudjonsson, S Karason, GH Gudmundsson
PeerJ 3, e1483, 2015
172015
Antimicrobials from a feline commensal bacterium inhibit skin infection by drug-resistant S. pseudintermedius
AM O'Neill, KA Worthing, N Kulkarni, F Li, T Nakatsuji, D McGrosso, ...
Elife 10, e66793, 2021
142021
Sequence determinants in the cathelicidin LL-37 that promote inflammation via presentation of RNA to scavenger receptors
NN Kulkarni, AM O’Neill, T Dokoshi, EWC Luo, GCL Wong, RL Gallo
Journal of Biological Chemistry 297 (1), 2021
112021
Viral afterlife: SARS-CoV-2 as a reservoir of immunomimetic peptides that reassemble into proinflammatory supramolecular complexes
Y Zhang, V Bharathi, T Dokoshi, J de Anda, LT Ursery, NN Kulkarni, ...
Proceedings of the National Academy of Sciences 121 (6), e2300644120, 2024
82024
3D genomic features across> 50 diverse cell types reveal insights into the genomic architecture of childhood obesity
KB Trang, MC Pahl, JA Pippin, C Su, SH Littleton, P Sharma, NN Kulkarni, ...
medRxiv, 2023
12023
886 Discovery of a receptor-dependent step in cathelicidin activation of inflammation identifies a novel therapeutic target for psoriasis and rosacea
T Takahashi, NN Kulkarni, EY Lee, L Zhang, GCL Wong, S Aiba, RL Gallo
Journal of Investigative Dermatology 138 (5), S151, 2018
12018
Increased LL37 in psoriasis and other inflammatory disorders promotes LDL uptake and atherosclerosis
Y Nakamura, NN Kulkarni, T Takahashi, H Alimohamadi, T Dokoshi, E Liu, ...
The Journal of clinical investigation 134 (5), 2024
2024
531 Cardiovascular comorbidities are associated with increased LL37 which promotes the uptake of low-density lipoprotein into macrophages
RG Y Nakamura, Nikhil K, T Dokoshi, E Luo, G Wong
Journal of Investigative Dermatology 142 (8 Supplement), S90, 2022
2022
207 Targeting of HDAC8 and HDAC9 in keratinocytes to enhance skin immune defense
Y Sawada, T Dokoshi, N Kulkarni, M Liggins, T Nakatsuji, G Sen, R Gallo
Journal of Investigative Dermatology 141 (5), S37, 2021
2021
337 Innate immune tolerance of the epidermis is mediated by epigenetic regulation of MAP2K3
Y Sawada, T Nakatsuji, T Dokoshi, N Kulkarni, J Jones, G Sen, M Liggins, ...
Journal of Investigative Dermatology 140 (7), S42, 2020
2020
LL-37 promotes endothelial photo-sensitivity and adhesion molecule expression in Rosacea
NN Kulkarni, T Takahashi, L Tong, JY Cheng, RL Gallo
Journal of Investigative Dermatology 139 (5), S126-S126, 2019
2019
1170 LL-37 acts on dermal microvascular endothelial cells to potentiate non-coding double strandedds RNA induced inflammation. An explanation for photosensitivity in Rosacea
NN Kulkarni, C Adase, RL Gallo
Journal of Investigative Dermatology 138 (5), S199, 2018
2018
Cyclic stretch and expression of innate immune effectors in lung epithelial cell lines
H Karadottir, NN Kulkarni, T Gudjonsson, GH Gudmundsson, S Karason
ACTA ANAESTHESIOLOGICA SCANDINAVICA 59, 30-30, 2015
2015
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