| Total synthesis of a functional designer eukaryotic chromosome N Annaluru, H Muller, LA Mitchell, S Ramalingam, G Stracquadanio, ... Science 344 (6179), 55-58, 2014 | 651 | 2014 |
| TDP-43 repression of nonconserved cryptic exons is compromised in ALS-FTD JP Ling, O Pletnikova, JC Troncoso, PC Wong Science 349 (6248), 650-655, 2015 | 488 | 2015 |
| Deletion of TDP-43 down-regulates Tbc1d1, a gene linked to obesity, and alters body fat metabolism PM Chiang, J Ling, YH Jeong, DL Price, SM Aja, PC Wong Proceedings of the National Academy of Sciences 107 (37), 16320-16324, 2010 | 340 | 2010 |
| Rodent models of TDP-43: recent advances W Tsao, YH Jeong, S Lin, J Ling, DL Price, PM Chiang, PC Wong Brain research 1462 (26), 26-39, 2012 | 127 | 2012 |
| recount3: summaries and queries for large-scale RNA-seq expression and splicing C Wilks, SC Zheng, FY Chen, R Charles, B Solomon, JP Ling, EL Imada, ... Genome Biology 22 (1), 1-40, 2021 | 122 | 2021 |
| Tdp-43 cryptic exons are highly variable between cell types YH Jeong, JP Ling, SZ Lin, AN Donde, KE Braunstein, E Majounie, ... Molecular neurodegeneration 12 (1), 2017 | 76 | 2017 |
| Splicing repression is a major function of TDP-43 in motor neurons A Donde, M Sun, JP Ling, KE Braunstein, B Pang, X Wen, X Cheng, ... Acta Neuropathologica, 2019 | 72 | 2019 |
| PTBP1 and PTBP2 repress nonconserved cryptic exons JP Ling, R Chhabra, JD Merran, PM Schaughency, SJ Wheelan, ... Cell reports 17 (1), 104-113, 2016 | 66 | 2016 |
| ASCOT identifies key regulators of neuronal subtype-specific splicing JP Ling, C Wilks, R Charles, PJ Leavey, D Ghosh, L Jiang, CP Santiago, ... Nature communications 11 (1), 137, 2020 | 63 | 2020 |
| Cryptic exon incorporation occurs in Alzheimer’s brain lacking TDP-43 inclusion but exhibiting nuclear clearance of TDP-43 M Sun, W Bell, KD LaClair, JP Ling, H Han, Y Kageyama, O Pletnikova, ... Acta neuropathologica 133, 923-931, 2017 | 57 | 2017 |
| Depletion of TDP-43 decreases fibril and plaque β-amyloid and exacerbates neurodegeneration in an Alzheimer’s mouse model KD LaClair, A Donde, JP Ling, YH Jeong, R Chhabra, LJ Martin, ... Acta neuropathologica 132, 859-873, 2016 | 44 | 2016 |
| HnRNP L represses cryptic exons SP McClory, KW Lynch, JP Ling RNA 24 (6), 1-9, 2018 | 37 | 2018 |
| Loss of TDP-43 function and rimmed vacuoles persist after T cell depletion in a xenograft model of sporadic inclusion body myositis KA Britson, JP Ling, KE Braunstein, JM Montagne, JM Kastenschmidt, ... Science translational medicine 14 (628), eabi9196, 2022 | 36 | 2022 |
| An LHX1-regulated transcriptional network controls sleep/wake coupling and thermal resistance of the central circadian clockworks JL Bedont, TA LeGates, E Buhr, A Bathini, JP Ling, B Bell, MN Wu, ... Current Biology 27 (1), 128-136, 2017 | 36 | 2017 |
| Upregulation of ATG7 attenuates motor neuron dysfunction associated with depletion of TARDBP/TDP-43 A Donde, M Sun, YH Jeong, X Wen, J Ling, S Lin, K Braunstein, S Nie, ... Autophagy 16 (4), 672-682, 2019 | 33 | 2019 |
| A fluid biomarker reveals loss of TDP-43 splicing repression in presymptomatic ALS–FTD KE Irwin, P Jasin, KE Braunstein, IR Sinha, MA Garret, KD Bowden, ... Nature medicine, 1-12, 2024 | 28 | 2024 |
| Response to vinorelbine with or without estramustine as second-line chemotherapy in patients with hormone-refractory prostate cancer M Nakabayashi, J Ling, W Xie, MM Regan, WK Oh The Cancer Journal 13 (2), 125-129, 2007 | 26 | 2007 |
| Amyloid-beta and tau pathologies act synergistically to induce novel disease stage-specific microglia subtypes DW Kim, KJ Tu, A Wei, AJ Lau, A Gonzalez-Gil, T Cao, K Braunstein, ... Molecular neurodegeneration 17 (1), 83, 2022 | 23 | 2022 |
| Stage-specific control of oligodendrocyte survival and morphogenesis by TDP-43 D Heo, JP Ling, GC Molina-Castro, AJ Langseth, A Waisman, KA Nave, ... Elife 11, e75230, 2022 | 21 | 2022 |
| Cell-specific regulation of gene expression using splicing-dependent frameshifting JP Ling, AM Bygrave, CP Santiago, RP Carmen-Orozco, VT Trinh, M Yu, ... Nature Communications 13 (1), 5773, 2022 | 9 | 2022 |
Juan TroncosoProfessor of Pathology, Johns Hopkins University School of MedicineVerified email at jhmi.edu
