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Kurt Brunden
Kurt Brunden
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Year
ApoE-directed therapeutics rapidly clear β-amyloid and reverse deficits in AD mouse models
PE Cramer, JR Cirrito, DW Wesson, CYD Lee, JC Karlo, AE Zinn, ...
science 335 (6075), 1503-1506, 2012
12352012
Exogenous α-synuclein fibrils seed the formation of Lewy body-like intracellular inclusions in cultured cells
KC Luk, C Song, P O'Brien, A Stieber, JR Branch, KR Brunden, ...
Proceedings of the National Academy of Sciences 106 (47), 20051-20056, 2009
10642009
Advances in tau-focused drug discovery for Alzheimer's disease and related tauopathies
KR Brunden, JQ Trojanowski, VMY Lee
Nature reviews Drug discovery 8 (10), 783-793, 2009
5722009
Amyloid-β plaques enhance Alzheimer's brain tau-seeded pathologies by facilitating neuritic plaque tau aggregation
Z He, JL Guo, JD McBride, S Narasimhan, H Kim, L Changolkar, B Zhang, ...
Nature medicine 24 (1), 29-38, 2018
5592018
The microtubule-stabilizing agent, epothilone D, reduces axonal dysfunction, neurotoxicity, cognitive deficits, and Alzheimer-like pathology in an interventional study with …
B Zhang, J Carroll, JQ Trojanowski, Y Yao, M Iba, JS Potuzak, ...
Journal of Neuroscience 32 (11), 3601-3611, 2012
4092012
Evidence for glial-mediated inflammation in aged APPSW transgenic mice
WC Benzing, JR Wujek, EK Ward, D Shaffer, KH Ashe, SG Younkin, ...
Neurobiology of aging 20 (6), 581-589, 1999
3881999
Amyloid fibrils activate tyrosine kinase-dependent signaling and superoxide production in microglia
DR McDonald, KR Brunden, GE Landreth
Journal of Neuroscience 17 (7), 2284-2294, 1997
3881997
Lewy Body-like α-Synuclein Aggregates Resist Degradation and Impair Macroautophagy*♦
SA Tanik, CE Schultheiss, LA Volpicelli-Daley, KR Brunden, VMY Lee
Journal of Biological Chemistry 288 (21), 15194-15210, 2013
3592013
Epothilone D improves microtubule density, axonal integrity, and cognition in a transgenic mouse model of tauopathy
KR Brunden, B Zhang, J Carroll, Y Yao, JS Potuzak, AML Hogan, M Iba, ...
Journal of Neuroscience 30 (41), 13861-13866, 2010
3322010
Identification of a novel extracellular cation-sensing G-protein-coupled receptor
M Pi, P Faber, G Ekema, PD Jackson, A Ting, N Wang, M Fontilla-Poole, ...
Journal of Biological Chemistry 280 (48), 40201-40209, 2005
3322005
GPRC6A null mice exhibit osteopenia, feminization and metabolic syndrome
M Pi, L Chen, MZ Huang, W Zhu, B Ringhofer, J Luo, L Christenson, B Li, ...
PloS one 3 (12), e3858, 2008
2812008
Amyloid β and amylin fibrils induce increases in proinflammatory cytokine and chemokine production by THP‐1 cells and murine microglia
SL Yates, LH Burgess, J Kocsis‐Angle, JM Antal, MD Dority, PB Embury, ...
Journal of neurochemistry 74 (3), 1017-1025, 2000
2722000
Response to comments on “ApoE-directed therapeutics rapidly clear β-amyloid and reverse deficits in AD mouse models”
GE Landreth, PE Cramer, MM Lakner, JR Cirrito, DW Wesson, ...
Science 340 (6135), 924-924, 2013
2692013
Chronic stress exacerbates tau pathology, neurodegeneration, and cognitive performance through a corticotropin-releasing factor receptor-dependent mechanism in a transgenic …
JC Carroll, M Iba, DA Bangasser, RJ Valentino, MJ James, KR Brunden, ...
Journal of Neuroscience 31 (40), 14436-14449, 2011
2672011
Microtubule stabilizing agents as potential treatment for Alzheimer’s disease and related neurodegenerative tauopathies
C Ballatore, KR Brunden, DM Huryn, JQ Trojanowski, VMY Lee, ...
American Chemical Society, 2012
2532012
Amyloid β protein (Aβ) removal by neuroglial cells in culture
LM Shaffer, MD Dority, R Gupta-Bansal, RCA Frederickson, SG Younkin, ...
Neurobiology of aging 16 (5), 737-745, 1995
2401995
Structure property relationships of carboxylic acid isosteres
P Lassalas, B Gay, C Lasfargeas, MJ James, V Tran, KG Vijayendran, ...
Journal of medicinal chemistry 59 (7), 3183-3203, 2016
2392016
Proteoglycan-mediated inhibition of Aβ proteolysis: A potential cause of senile plaque accumulation
R Gupta-Bansal, RCA Frederickson, KR Brunden
Journal of Biological Chemistry 270 (31), 18666-18671, 1995
2191995
Intracerebral injection of preformed synthetic tau fibrils initiates widespread tauopathy and neuronal loss in the brains of tau transgenic mice
E Peeraer, A Bottelbergs, K Van Kolen, IC Stancu, B Vasconcelos, ...
Neurobiology of disease 73, 83-95, 2015
2142015
pH‐Dependent Binding of Synthetic β‐Amyloid Peptides to Glycosaminoglycans
KR Brunden, NJ Richter‐Cook, N Chaturvedi, RCA Frederickson
Journal of neurochemistry 61 (6), 2147-2154, 1993
1961993
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Articles 1–20