AMPK–SKP2–CARM1 signalling cascade in transcriptional regulation of autophagy HJR Shin, H Kim, S Oh, JG Lee, M Kee, HJ Ko, MN Kweon, KJ Won, ... Nature 534 (7608), 553-557, 2016 | 383 | 2016 |
ER–lysosome contacts enable cholesterol sensing by mTORC1 and drive aberrant growth signalling in Niemann–Pick type C CY Lim, OB Davis, HR Shin, J Zhang, CA Berdan, X Jiang, JL Counihan, ... Nature cell biology 21 (10), 1206-1218, 2019 | 226 | 2019 |
Negative regulation of hypoxic responses via induced Reptin methylation JS Lee, Y Kim, IS Kim, B Kim, HJ Choi, JM Lee, HJR Shin, JH Kim, JY Kim, ... Molecular cell 39 (1), 71-85, 2010 | 193 | 2010 |
Hypoxia-induced methylation of a pontin chromatin remodeling factor JS Lee, Y Kim, J Bhin, HJR Shin, HJ Nam, SH Lee, JB Yoon, O Binda, ... Proceedings of the National Academy of Sciences 108 (33), 13510-13515, 2011 | 133 | 2011 |
Covalent targeting of the vacuolar H+-ATPase activates autophagy via mTORC1 inhibition CYS Chung, HR Shin, CA Berdan, B Ford, CC Ward, JA Olzmann, ... Nature chemical biology 15 (8), 776-785, 2019 | 132 | 2019 |
NPC1-mTORC1 signaling couples cholesterol sensing to organelle homeostasis and is a targetable pathway in Niemann-Pick type C OB Davis, HR Shin, CY Lim, EY Wu, M Kukurugya, CF Maher, RM Perera, ... Developmental cell 56 (3), 260-276. e7, 2021 | 115 | 2021 |
The lysosome at the intersection of cellular growth and destruction HR Shin, R Zoncu Developmental cell 54 (2), 226-238, 2020 | 84 | 2020 |
PKCα-LSD1-NF-κB-signaling cascade is crucial for epigenetic control of the inflammatory response D Kim, HJ Nam, W Lee, HY Yim, JY Ahn, SW Park, HJR Shin, R Yu, ... Molecular cell 69 (3), 398-411. e6, 2018 | 79 | 2018 |
Epigenetic and transcriptional regulation of autophagy HJR Shin, H Kim, KI Kim, SH Baek Autophagy 12 (11), 2248-2249, 2016 | 54 | 2016 |
Bcl3-dependent stabilization of CtBP1 is crucial for the inhibition of apoptosis and tumor progression in breast cancer HJ Choi, JM Lee, H Kim, HJ Nam, HJR Shin, D Kim, E Ko, DY Noh, KI Kim, ... Biochemical and biophysical research communications 400 (3), 396-402, 2010 | 53 | 2010 |
Lysosomal retargeting of Myoferlin mitigates membrane stress to enable pancreatic cancer growth S Gupta, J Yano, V Mercier, HH Htwe, HR Shin, G Rademaker, Z Cakir, ... Nature cell biology 23 (3), 232-242, 2021 | 44 | 2021 |
Lysosomal GPCR-like protein LYCHOS signals cholesterol sufficiency to mTORC1 HR Shin, YR Citron, L Wang, L Tribouillard, CS Goul, R Stipp, ... Science 377 (6612), 1290-1298, 2022 | 37 | 2022 |
Pontin arginine methylation by CARM1 is crucial for epigenetic regulation of autophagy YS Yu, HR Shin, D Kim, SA Baek, SA Choi, H Ahn, A Shamim, J Kim, ... Nature communications 11 (1), 6297, 2020 | 36 | 2020 |
Pontin functions as an essential coactivator for Oct4-dependent lincRNA expression in mouse embryonic stem cells K Boo, J Bhin, Y Jeon, J Kim, HJR Shin, JE Park, K Kim, CR Kim, H Jang, ... Nature communications 6 (1), 6810, 2015 | 28 | 2015 |
Nat. Photonics 11, 708 (2017) HS Kang, CK Min, H Heo, C Kim, H Yang, G Kim, I Nam, SY Baek, ... | 12 | |
Finding sugar in the pantry: how galectins detect and signal lysosomal damage HR Shin, R Zoncu Molecular cell 70 (1), 5-7, 2018 | 3 | 2018 |
The hypothalamic–pituitary–gonadal axis controls muscle stem cell senescence through autophagosome clearance JH Kim, I Park, HR Shin, J Rhee, JY Seo, YW Jo, K Yoo, SH Hann, ... Journal of cachexia, sarcopenia and muscle 12 (1), 177-191, 2021 | 2 | 2021 |
mTORC1 modulators DK Nomura, R Zoncu, AM Roberts, KF Cho, YSC Chung, H Shin, B Croze US Patent 10,807,951, 2020 | | 2020 |