| Towards the sustainable discovery and development of new antibiotics M Miethke, M Pieroni, T Weber, M Brönstrup, P Hammann, L Halby, ... Nature Reviews Chemistry 5 (10), 726-749, 2021 | 574 | 2021 |
| Phosphate recognition in structural biology AKH Hirsch, FR Fischer, F Diederich Angewandte Chemie International Edition 46 (3), 338-352, 2007 | 319 | 2007 |
| Dynamic combinatorial chemistry: a tool to facilitate the identification of inhibitors for protein targets M Mondal, AKH Hirsch Chemical Society Reviews 44 (8), 2455-2488, 2015 | 238 | 2015 |
| Concepts and core principles of fragment-based drug design P Kirsch, AM Hartman, AKH Hirsch, M Empting Molecules 24 (23), 4309, 2019 | 168 | 2019 |
| Structure‐Based Design of Inhibitors of the Aspartic Protease Endothiapepsin by Exploiting Dynamic Combinatorial Chemistry M Mondal, N Radeva, H Koester, A Park, C Potamitis, M Zervou, G Klebe, ... Angewandte Chemie International Edition 53 (12), 3259-3263, 2014 | 99 | 2014 |
| Development of Inhibitors of the 2C-Methyl-d-erythritol 4-Phosphate (MEP) Pathway Enzymes as Potential Anti-Infective Agents T Masini, AKH Hirsch Journal of medicinal chemistry 57 (23), 9740-9763, 2014 | 95 | 2014 |
| From wood to tetrahydro-2-benzazepines in three waste-free steps: modular synthesis of biologically active lignin-derived scaffolds S Elangovan, A Afanasenko, J Haupenthal, Z Sun, Y Liu, AKH Hirsch, ... ACS central science 5 (10), 1707-1716, 2019 | 92 | 2019 |
| Fragment Linking and Optimization of Inhibitors of the Aspartic Protease Endothiapepsin: Fragment‐Based Drug Design Facilitated by Dynamic Combinatorial Chemistry M Mondal, N Radeva, H Fanlo‐Virgós, S Otto, G Klebe, AKH Hirsch Angewandte Chemie International Edition 55 (32), 9422-9426, 2016 | 91 | 2016 |
| Fighting antibiotic resistance—strategies and (pre) clinical developments to find new antibacterials S Walesch, J Birkelbach, G Jézéquel, FPJ Haeckl, JD Hegemann, ... EMBO reports 24 (1), e56033, 2023 | 72 | 2023 |
| Molecular biodynamers: dynamic covalent analogues of biopolymers Y Liu, JM Lehn, AKH Hirsch Accounts of Chemical Research 50 (2), 376-386, 2017 | 71 | 2017 |
| Biodynamers: self-organization-driven formation of doubly dynamic proteoids AKH Hirsch, E Buhler, JM Lehn Journal of the American Chemical Society 134 (9), 4177-4183, 2012 | 63 | 2012 |
| Nonphosphate Inhibitors of IspE Protein, a Kinase in the Non‐Mevalonate Pathway for Isoprenoid Biosynthesis and a Potential Target for Antimalarial Therapy AKH Hirsch, S Lauw, P Gersbach, WB Schweizer, F Rohdich, ... ChemMedChem: Chemistry Enabling Drug Discovery 2 (6), 806-810, 2007 | 63 | 2007 |
| Druggability of the enzymes of the non-mevalonate-pathway T Masini, BS Kroezen, AKH Hirsch Drug Discovery Today 18 (23-24), 1256-1262, 2013 | 60 | 2013 |
| Citraconate inhibits ACOD1 (IRG1) catalysis, reduces interferon responses and oxidative stress, and modulates inflammation and cell metabolism F Chen, WAM Elgaher, M Winterhoff, K Büssow, FH Waqas, E Graner, ... Nature Metabolism 4 (5), 534-546, 2022 | 57 | 2022 |
| Exploiting specific interactions toward next-generation polymeric drug transporters S Wieczorek, E Krause, S Hackbarth, B Röder, AKH Hirsch, HG Börner Journal of the American Chemical Society 135 (5), 1711-1714, 2013 | 54 | 2013 |
| Structure‐based design of potent small‐molecule binders to the S‐component of the ECF transporter for thiamine LJYM Swier, L Monjas, A Guskov, AR de Voogd, GB Erkens, DJ Slotboom, ... ChemBioChem 16 (5), 819-826, 2015 | 53 | 2015 |
| Mastering the Gram-negative bacterial barrier–Chemical approaches to increase bacterial bioavailability of antibiotics HK Ropponen, R Richter, AKH Hirsch, CM Lehr Advanced Drug Delivery Reviews 172, 339-360, 2021 | 52 | 2021 |
| Tracheal brush cells release acetylcholine in response to bitter tastants for paracrine and autocrine signaling MI Hollenhorst, I Jurastow, R Nandigama, S Appenzeller, L Li, J Vogel, ... FASEB Journal 34 (1), 316-332, 2020 | 52 | 2020 |
| Flotillin-mediated membrane fluidity controls peptidoglycan synthesis and MreB movement A Zielińska, A Savietto, A de Sousa Borges, D Martinez, M Berbon, ... Elife 9, e57179, 2020 | 51 | 2020 |
| Inhibitors of the kinase IspE: structure–activity relationships and co-crystal structure analysis AKH Hirsch, MS Alphey, S Lauw, M Seet, L Barandun, W Eisenreich, ... Organic & biomolecular chemistry 6 (15), 2719-2730, 2008 | 49 | 2008 |
