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Andrés Pastor-Fernández
Andrés Pastor-Fernández
IMDEA Food
Verified email at imdea.org
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Year
A DHODH inhibitor increases p53 synthesis and enhances tumor cell killing by p53 degradation blockage
MJGW Ladds, IMM Van Leeuwen, CJ Drummond, S Chu, AR Healy, ...
Nature communications 9 (1), 1107, 2018
862018
Exploitation of dihydroorotate dehydrogenase (DHODH) and p53 activation as therapeutic targets: A case study in polypharmacology
MJGW Ladds, G Popova, A Pastor-Fernández, S Kannan, ...
Journal of Biological Chemistry 295 (52), 17935-17949, 2020
112020
Treatment with the senolytics dasatinib/quercetin reduces SARS‐CoV‐2‐related mortality in mice
A Pastor‐Fernández, AR Bertos, A Sierra‐Ramírez, J del Moral‐Salmoral, ...
Aging Cell 22 (3), e13771, 2023
82023
Autophagic flux blockage by accumulation of weakly basic tenovins leads to elimination of B-Raf mutant tumour cells that survive vemurafenib
MJGW Ladds, A Pastor-Fernandez, G Popova, IMM van Leeuwen, ...
Plos one 13 (4), e0195956, 2018
52018
Dihydroorotate dehydrogenase inhibition acts synergistically with tyrosine kinase inhibitors to induce apoptosis of mantle cell lymphoma cells
M Eriksen‐Gjerstad, I Tveit Karlsen, Z Fandalyuk, S Benjaminsen, ...
EJHaem 3 (3), 913-918, 2022
22022
p21 is necessary for the beneficial effects of fasting during chemotherapy
A Plaza, A Pastor‐Fernández, JL López‐Aceituno, M Barradas, C Pantoja, ...
Cancer Communications 43 (1), 164, 2023
12023
Sexual dimorphism in the antitumor immune responses elicited by the combination of fasting and chemotherapy
A Pastor-Fernández, MMG de Las Heras, JI Escrig-Larena, M Barradas, ...
Cancer communications (London, England), 2024
2024
Retinoblastoma vulnerability to combined de novo and salvage pyrimidine ribonucleotide synthesis pharmacologic blockage
T Mollick, S Darekar, B Dalarun, F Plastino, J Zhang, AP Fernández, ...
Heliyon 10 (1), 2024
2024
Pharmacological and genetic increases in liver NADPH levels ameliorate NASH progression in female mice
I Rodriguez-Ramiro, A Pastor-Fernández, JL López-Aceituno, ...
Free Radical Biology and Medicine 210, 448-461, 2024
2024
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