A DHODH inhibitor increases p53 synthesis and enhances tumor cell killing by p53 degradation blockage MJGW Ladds, IMM Van Leeuwen, CJ Drummond, S Chu, AR Healy, ... Nature communications 9 (1), 1107, 2018 | 86 | 2018 |
Exploitation of dihydroorotate dehydrogenase (DHODH) and p53 activation as therapeutic targets: A case study in polypharmacology MJGW Ladds, G Popova, A Pastor-Fernández, S Kannan, ... Journal of Biological Chemistry 295 (52), 17935-17949, 2020 | 11 | 2020 |
Treatment with the senolytics dasatinib/quercetin reduces SARS‐CoV‐2‐related mortality in mice A Pastor‐Fernández, AR Bertos, A Sierra‐Ramírez, J del Moral‐Salmoral, ... Aging Cell 22 (3), e13771, 2023 | 8 | 2023 |
Autophagic flux blockage by accumulation of weakly basic tenovins leads to elimination of B-Raf mutant tumour cells that survive vemurafenib MJGW Ladds, A Pastor-Fernandez, G Popova, IMM van Leeuwen, ... Plos one 13 (4), e0195956, 2018 | 5 | 2018 |
Dihydroorotate dehydrogenase inhibition acts synergistically with tyrosine kinase inhibitors to induce apoptosis of mantle cell lymphoma cells M Eriksen‐Gjerstad, I Tveit Karlsen, Z Fandalyuk, S Benjaminsen, ... EJHaem 3 (3), 913-918, 2022 | 2 | 2022 |
p21 is necessary for the beneficial effects of fasting during chemotherapy A Plaza, A Pastor‐Fernández, JL López‐Aceituno, M Barradas, C Pantoja, ... Cancer Communications 43 (1), 164, 2023 | 1 | 2023 |
Sexual dimorphism in the antitumor immune responses elicited by the combination of fasting and chemotherapy A Pastor-Fernández, MMG de Las Heras, JI Escrig-Larena, M Barradas, ... Cancer communications (London, England), 2024 | | 2024 |
Retinoblastoma vulnerability to combined de novo and salvage pyrimidine ribonucleotide synthesis pharmacologic blockage T Mollick, S Darekar, B Dalarun, F Plastino, J Zhang, AP Fernández, ... Heliyon 10 (1), 2024 | | 2024 |
Pharmacological and genetic increases in liver NADPH levels ameliorate NASH progression in female mice I Rodriguez-Ramiro, A Pastor-Fernández, JL López-Aceituno, ... Free Radical Biology and Medicine 210, 448-461, 2024 | | 2024 |