| Three genomes differentially contribute to the biosynthesis of benzoxazinones in hexaploid wheat T Nomura, A Ishihara, RC Yanagita, TR Endo, H Iwamura Proceedings of the National Academy of Sciences 102 (45), 16490-16495, 2005 | 142 | 2005 |
| A simple analogue of tumor-promoting aplysiatoxin is an antineoplastic agent rather than a tumor promoter: development of a synthetically accessible protein kinase C activator … Y Nakagawa, RC Yanagita, N Hamada, A Murakami, H Takahashi, ... Journal of the American Chemical Society 131 (22), 7573-7579, 2009 | 88 | 2009 |
| Structure–activity studies on the spiroketal moiety of a simplified analogue of debromoaplysiatoxin with antiproliferative activity M Kikumori, RC Yanagita, H Tokuda, N Suzuki, H Nagai, K Suenaga, ... Journal of Medicinal Chemistry 55 (11), 5614-5626, 2012 | 57 | 2012 |
| Effects of two sulfated triterpene saponins echinoside A and holothurin A on the inhibition of dietary fat absorption and obesity reduction Y Wang, J Wang, RC Yanagita, C Liu, X Hu, P Dong, C Xue, Y Xue Bioscience, Biotechnology, and Biochemistry 78 (1), 139-146, 2014 | 49 | 2014 |
| Synthesis, conformational analysis, and biological evaluation of 1-hexylindolactam-V10 as a selective activator for novel protein kinase C isozymes RC Yanagita, Y Nakagawa, N Yamanaka, K Kashiwagi, N Saito, K Irie Journal of medicinal chemistry 51 (1), 46-56, 2008 | 49 | 2008 |
| Indolactam-V is involved in the CH/π interaction with Pro-11 of the PKCδ C1B domain: application for the structural optimization of the PKCδ ligand Y Nakagawa, K Irie, RC Yanagita, H Ohigashi, K Tsuda Journal of the American Chemical Society 127 (16), 5746-5747, 2005 | 48 | 2005 |
| Synthesis and biological activities of simplified analogs of the natural PKC ligands, bryostatin‐1 and aplysiatoxin K Irie, RC Yanagita The Chemical Record 14 (2), 251-267, 2014 | 45 | 2014 |
| Challenges to the development of bryostatin‐type anticancer drugs based on the activation mechanism of protein kinase Cδ K Irie, RC Yanagita, Y Nakagawa Medicinal research reviews 32 (3), 518-535, 2012 | 37 | 2012 |
| Generation of ‘Unnatural Natural Product’library and identification of a small molecule inhibitor of XIAP T Kawamura, K Matsubara, H Otaka, E Tashiro, K Shindo, RC Yanagita, ... Bioorganic & medicinal chemistry 19 (14), 4377-4385, 2011 | 37 | 2011 |
| Design and synthesis of 8-octyl-benzolactam-V9, a selective activator for protein kinase Cε and η Y Nakagawa, K Irie, RC Yanagita, H Ohigashi, K Tsuda, K Kashiwagi, ... Journal of medicinal chemistry 49 (9), 2681-2688, 2006 | 31 | 2006 |
| Role of the phenolic hydroxyl group in the biological activities of simplified analogue of aplysiatoxin with antiproliferative activity RC Yanagita, H Kamachi, K Tanaka, A Murakami, Y Nakagawa, H Tokuda, ... Bioorganic & medicinal chemistry letters 20 (20), 6064-6066, 2010 | 26 | 2010 |
| Binding mode prediction of aplysiatoxin, a potent agonist of protein kinase C, through molecular simulation and structure–activity study on simplified analogs of the receptor … Y Ashida, RC Yanagita, C Takahashi, Y Kawanami, K Irie Bioorganic & Medicinal Chemistry 24 (18), 4218-4227, 2016 | 22 | 2016 |
| Structure–activity studies on the side chain of a simplified analog of aplysiatoxin (aplog-1) with anti-proliferative activity H Kamachi, K Tanaka, RC Yanagita, A Murakami, K Murakami, H Tokuda, ... Bioorganic & medicinal chemistry 21 (10), 2695-2702, 2013 | 22 | 2013 |
| Effects of the methoxy group in the side chain of debromoaplysiatoxin on its tumor-promoting and anti-proliferative activities RC Yanagita, H Kamachi, M Kikumori, H Tokuda, N Suzuki, K Suenaga, ... Bioorganic & medicinal chemistry letters 23 (15), 4319-4323, 2013 | 21 | 2013 |
| Improved and large-scale synthesis of 10-methyl-aplog-1, a potential lead for an anticancer drug M Kikumori, RC Yanagita, K Irie Tetrahedron 70 (52), 9776-9782, 2014 | 20 | 2014 |
| Synthesis and biological evaluation of the 12, 12-dimethyl derivative of Aplog-1, an anti-proliferative analog of tumor-promoting aplysiatoxin Y Nakagawa, M Kikumori, RC Yanagita, A Murakami, H Tokuda, H Nagai, ... Bioscience, biotechnology, and biochemistry 75 (6), 1167-1173, 2011 | 19 | 2011 |
| Synthesis and biochemical characterization of quasi-stable trimer models of full-length amyloid β40 with a toxic conformation Y Irie, M Hanaki, K Murakami, T Imamoto, T Furuta, T Kawabata, ... Chemical communications 55 (2), 182-185, 2019 | 18 | 2019 |
| Practical enantioselective reduction of ketones using oxazaborolidine catalysts generated in situ from chiral lactam alcohols Y Kawanami, RC Yanagita Molecules 23 (10), 2408, 2018 | 16 | 2018 |
| Structural optimization of 10-methyl-aplog-1, a simplified analog of debromoaplysiatoxin, as an anticancer lead M Kikumori, RC Yanagita, H Tokuda, K Suenaga, H Nagai, K Irie Bioscience, Biotechnology, and Biochemistry 80 (2), 221-231, 2016 | 16 | 2016 |
| Synthesis and structure–activity studies of simplified analogues of aplysiatoxin with antiproliferative activity like bryostatin-1 K Irie, M Kikumori, H Kamachi, K Tanaka, A Murakami, RC Yanagita, ... Pure and Applied Chemistry 84 (6), 1341-1351, 2012 | 16 | 2012 |
