Integrative genome analyses identify key somatic driver mutations of small-cell lung cancer M Peifer, L Fernández-Cuesta, ML Sos, J George, D Seidel, LH Kasper, ... Nature genetics 44 (10), 1104-1110, 2012 | 1462 | 2012 |
The CREB coactivator TORC2 is a key regulator of fasting glucose metabolism SH Koo, L Flechner, L Qi, X Zhang, RA Screaton, S Jeffries, S Hedrick, ... Nature 437 (7062), 1109-1114, 2005 | 1202 | 2005 |
Inactivating mutations of acetyltransferase genes in B-cell lymphoma L Pasqualucci, D Dominguez-Sola, A Chiarenza, G Fabbri, A Grunn, ... Nature 471 (7337), 189-195, 2011 | 1060 | 2011 |
Activation of cAMP and mitogen responsive genes relies on a common nuclear factor J Arias, AS Alberts, P Brindle, FX Claret, T Smeal, M Karin, J Feramisco, ... Nature 370 (6486), 226-229, 1994 | 1003 | 1994 |
Histone deacetylase inhibitors enhance memory and synaptic plasticity via CREB: CBP-dependent transcriptional activation CG Vecsey, JD Hawk, KM Lattal, JM Stein, SA Fabian, MA Attner, ... Journal of Neuroscience 27 (23), 6128-6140, 2007 | 965 | 2007 |
Distinct roles of GCN5/PCAF‐mediated H3K9ac and CBP/p300‐mediated H3K18/27ac in nuclear receptor transactivation Q Jin, LR Yu, L Wang, Z Zhang, LH Kasper, JE Lee, C Wang, PK Brindle, ... The EMBO journal 30 (2), 249-262, 2011 | 843 | 2011 |
CREBBP mutations in relapsed acute lymphoblastic leukaemia CG Mullighan, J Zhang, LH Kasper, S Lerach, D Payne-Turner, ... Nature 471 (7337), 235-239, 2011 | 696 | 2011 |
Transcriptional attenuation following cAMP induction requires PP-1-mediated dephosphorylation of CREB M Hagiwara, A Alberts, P Brindle, J Meinkoth, J Feramisco, T Deng, ... Cell 70 (1), 105-113, 1992 | 606 | 1992 |
Coupling of hormonal stimulation and transcription via the cyclic AMP-responsive factor CREB is rate limited by nuclear entry of protein kinase A M Hagiwara, P Brindle, A Harootunian, R Armstrong, J Rivier, W Vale, ... Molecular and cellular biology, 1993 | 535 | 1993 |
The CREB family of transcription activators PK Brindle, MR Montminy Current opinion in genetics & development 2 (2), 199-204, 1992 | 406 | 1992 |
CREB binding protein interacts with nucleoporin-specific FG repeats that activate transcription and mediate NUP98-HOXA9 oncogenicity LH Kasper, PK Brindle, CA Schnabel, CEJ Pritchard, ML Cleary, ... Molecular and cellular biology 19 (1), 764-776, 1999 | 379 | 1999 |
Target gene context influences the transcriptional requirement for the KAT3 family of CBP and p300 histone acetyltransferases DC Bedford, LH Kasper, T Fukuyama, PK Brindle Epigenetics 5 (1), 9-15, 2010 | 355 | 2010 |
A role for CREB binding protein and p300 transcriptional coactivators in Ets-1 transactivation functions C Yang, LH Shapiro, M Rivera, A Kumar, PK Brindle Molecular and cellular biology 18 (4), 2218-2229, 1998 | 248 | 1998 |
Conditional knockout mice reveal distinct functions for the global transcriptional coactivators CBP and p300 in T-cell development LH Kasper, T Fukuyama, MA Biesen, F Boussouar, C Tong, A De Pauw, ... Molecular and cellular biology 26 (3), 789-809, 2006 | 243 | 2006 |
Protein-kinase-A-dependent activator in transcription factor CREB reveals new role for CREM repressers P Brindle, S Linke, M Montminy Nature 364 (6440), 821-824, 1993 | 239 | 1993 |
A transcription-factor-binding surface of coactivator p300 is required for haematopoiesis LH Kasper, F Boussouar, PA Ney, CW Jackson, J Rehg, JM Van Deursen, ... Nature 419 (6908), 738-743, 2002 | 234 | 2002 |
A transcription factor-binding domain of the coactivator CBP is essential for long-term memory and the expression of specific target genes MA Wood, MA Attner, AMM Oliveira, PK Brindle, T Abel Learning & Memory 13 (5), 609-617, 2006 | 229 | 2006 |
Inhibition of p300 impairs Foxp3+ T regulatory cell function and promotes antitumor immunity Y Liu, L Wang, J Predina, R Han, UH Beier, LCS Wang, V Kapoor, ... Nature medicine 19 (9), 1173-1177, 2013 | 227 | 2013 |
The CREBBP acetyltransferase is a haploinsufficient tumor suppressor in B-cell lymphoma J Zhang, S Vlasevska, VA Wells, S Nataraj, AB Holmes, R Duval, ... Cancer discovery 7 (3), 322-337, 2017 | 225 | 2017 |
Multiple protein kinase A-regulated events are required for transcriptional induction by cAMP. P Brindle, T Nakajima, M Montminy Proceedings of the National Academy of Sciences 92 (23), 10521-10525, 1995 | 191 | 1995 |