| Enhanced endosomal escape of siRNA-incorporating hybrid nanoparticles from calcium phosphate and PEG-block charge-conversional polymer for efficient gene knockdown with … F Pittella, M Zhang, Y Lee, HJ Kim, T Tockary, K Osada, T Ishii, K Miyata, ... Biomaterials 32 (11), 3106-3114, 2011 | 193 | 2011 |
| Systemic delivery of messenger RNA for the treatment of pancreatic cancer using polyplex nanomicelles with a cholesterol moiety S Uchida, H Kinoh, T Ishii, A Matsui, TA Tockary, KM Takeda, H Uchida, ... Biomaterials 82, 221-228, 2016 | 141 | 2016 |
| Targeted gene delivery by polyplex micelles with crowded PEG palisade and cRGD moiety for systemic treatment of pancreatic tumors Z Ge, Q Chen, K Osada, X Liu, TA Tockary, S Uchida, A Dirisala, T Ishii, ... Biomaterials 35 (10), 3416-3426, 2014 | 135 | 2014 |
| Tethered PEG crowdedness determining shape and blood circulation profile of polyplex micelle gene carriers TA Tockary, K Osada, Q Chen, K Machitani, A Dirisala, S Uchida, ... Macromolecules 46 (16), 6585-6592, 2013 | 118 | 2013 |
| Targeting nanoparticles to the brain by exploiting the blood–brain barrier impermeability to selectively label the brain endothelium D Gonzalez-Carter, X Liu, TA Tockary, A Dirisala, K Toh, Y Anraku, ... Proceedings of the National Academy of Sciences 117 (32), 19141-19150, 2020 | 93 | 2020 |
| Optimized rod length of polyplex micelles for maximizing transfection efficiency and their performance in systemic gene therapy against stroma-rich pancreatic tumors A Dirisala, K Osada, Q Chen, TA Tockary, K Machitani, S Osawa, X Liu, ... Biomaterials 35 (20), 5359-5368, 2014 | 70 | 2014 |
| Homo-catiomer integration into PEGylated polyplex micelle from block-catiomer for systemic anti-angiogenic gene therapy for fibrotic pancreatic tumors Q Chen, K Osada, T Ishii, M Oba, S Uchida, TA Tockary, T Endo, Z Ge, ... Biomaterials 33 (18), 4722-4730, 2012 | 69 | 2012 |
| Dual-sensitive nanomicelles enhancing systemic delivery of therapeutically active antibodies specifically into the brain J Xie, D Gonzalez-Carter, TA Tockary, N Nakamura, Y Xue, M Nakakido, ... ACS nano 14 (6), 6729-6742, 2020 | 67 | 2020 |
| Enhanced gene expression promoted by the quantized folding of pDNA within polyplex micelles K Osada, T Shiotani, TA Tockary, D Kobayashi, H Oshima, S Ikeda, ... Biomaterials 33 (1), 325-332, 2012 | 66 | 2012 |
| Co-encapsulation of Cas9 mRNA and guide RNA in polyplex micelles enables genome editing in mouse brain S Abbasi, S Uchida, K Toh, TA Tockary, A Dirisala, K Hayashi, ... Journal of Controlled Release 332, 260-268, 2021 | 65 | 2021 |
| Effect of shear stress on structure and function of polyplex micelles from poly (ethylene glycol)-poly (l-lysine) block copolymers as systemic gene delivery carrier KM Takeda, Y Yamasaki, A Dirisala, S Ikeda, TA Tockary, K Toh, K Osada, ... Biomaterials 126, 31-38, 2017 | 64 | 2017 |
| Precise tuning of disulphide crosslinking in mRNA polyplex micelles for optimising extracellular and intracellular nuclease tolerability A Dirisala, S Uchida, TA Tockary, N Yoshinaga, J Li, S Osawa, L Gorantla, ... Journal of Drug Targeting 27 (5-6), 670-680, 2019 | 63 | 2019 |
| Polyplex micelle installing intracellular self-processing functionalities without free catiomers for safe and efficient systemic gene therapy through tumor vasculature targeting Q Chen, K Osada, Z Ge, S Uchida, TA Tockary, A Dirisala, A Matsui, K Toh, ... Biomaterials 113, 253-265, 2017 | 60 | 2017 |
| Transient stealth coating of liver sinusoidal wall by anchoring two-armed PEG for retargeting nanomedicines A Dirisala, S Uchida, K Toh, J Li, S Osawa, TA Tockary, X Liu, S Abbasi, ... Science Advances 6 (26), eabb8133, 2020 | 49 | 2020 |
| Poly (ethylene glycol) crowding as critical factor to determine pDNA packaging scheme into polyplex micelles for enhanced gene expression KM Takeda, K Osada, TA Tockary, A Dirisala, Q Chen, K Kataoka Biomacromolecules 18 (1), 36-43, 2017 | 44 | 2017 |
| Enzymatically Transformable Polymersome‐Based Nanotherapeutics to Eliminate Minimal Relapsable Cancer J Li, Z Ge, K Toh, X Liu, A Dirisala, W Ke, P Wen, H Zhou, Z Wang, S Xiao, ... Advanced Materials 33 (49), 2105254, 2021 | 42 | 2021 |
| Rod‐to‐Globule Transition of pDNA/PEG–Poly(l‐Lysine) Polyplex Micelles Induced by a Collapsed Balance Between DNA Rigidity and PEG Crowdedness TA Tockary, K Osada, Y Motoda, S Hiki, Q Chen, KM Takeda, A Dirisala, ... Small 12 (9), 1193-1200, 2016 | 40 | 2016 |
| Single-Stranded DNA-Packaged Polyplex Micelle as Adeno-Associated-Virus-Inspired Compact Vector to Systemically Target Stroma-Rich Pancreatic Cancer TA Tockary, W Foo, A Dirisala, Q Chen, S Uchida, S Osawa, Y Mochida, ... ACS nano 13 (11), 12732-12742, 2019 | 37 | 2019 |
| Toroidal Packaging of pDNA into Block Ionomer Micelles Exerting Promoted in Vivo Gene Expression Y Li, K Osada, Q Chen, TA Tockary, A Dirisala, KM Takeda, S Uchida, ... Biomacromolecules 16 (9), 2664-2671, 2015 | 28 | 2015 |
| Comb-structured mRNA vaccine tethered with short double-stranded RNA adjuvants maximizes cellular immunity for cancer treatment TA Tockary, S Abbasi, M Matsui-Masai, A Hayashi, N Yoshinaga, ... Proceedings of the National Academy of Sciences 120 (29), e2214320120, 2023 | 14 | 2023 |
