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Saimir Luli
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NFκB1 is a suppressor of neutrophil-driven hepatocellular carcinoma
CL Wilson, D Jurk, N Fullard, P Banks, A Page, S Luli, AM Elsharkawy, ...
Nature communications 6 (1), 6818, 2015
1772015
CXCR2 inhibition enables NASH-HCC immunotherapy
J Leslie, JBG Mackey, T Jamieson, E Ramon-Gil, TM Drake, F Fercoq, ...
Gut 71 (10), 2093-2106, 2022
792022
A proof-of-concept for epigenetic therapy of tissue fibrosis: inhibition of liver fibrosis progression by 3-deazaneplanocin A
M Zeybel, S Luli, L Sabater, T Hardy, F Oakley, J Leslie, A Page, ...
Molecular Therapy 25 (1), 218-231, 2017
742017
Inhibition of lysosomal protease cathepsin D reduces renal fibrosis in murine chronic kidney disease
C Fox, P Cocchiaro, F Oakley, R Howarth, K Callaghan, J Leslie, S Luli, ...
Scientific Reports 6 (1), 20101, 2016
692016
FPR-1 is an important regulator of neutrophil recruitment and a tissue-specific driver of pulmonary fibrosis
J Leslie, BJM Millar, A del Carpio Pons, RA Burgoyne, JD Frost, ...
JCI insight 5 (4), 2020
582020
Loss of endothelial endoglin promotes high-output heart failure through peripheral arteriovenous shunting driven by VEGF signaling
S Tual-Chalot, M Garcia-Collado, RE Redgrave, E Singh, B Davison, ...
Circulation Research 126 (2), 243-257, 2020
482020
Inhibition of RelA‐Ser536 phosphorylation by a competing peptide reduces mouse liver fibrosis without blocking the innate immune response
A Moles, AM Sanchez, PS Banks, LB Murphy, S Luli, L Borthwick, A Fisher, ...
Hepatology 57 (2), 817-828, 2013
432013
Fibrogenic activity of MECP2 is regulated by phosphorylation in hepatic stellate cells
E Moran-Salvador, M Garcia-Macia, A Sivaharan, L Sabater, MYW Zaki, ...
Gastroenterology 157 (5), 1398-1412. e9, 2019
312019
c-Rel orchestrates energy-dependent epithelial and macrophage reprogramming in fibrosis
J Leslie, MG Macia, S Luli, JC Worrell, WJ Reilly, HL Paish, A Knox, ...
Nature metabolism 2 (11), 1350-1367, 2020
282020
A new fluorescence-based optical imaging method to non-invasively monitor hepatic myofibroblasts in vivo
S Luli, D Di Paolo, P Perri, C Brignole, SJ Hill, H Brown, J Leslie, ...
Journal of hepatology 65 (1), 75-83, 2016
192016
Synthesis and In Vivo Evaluation of a Site-specifically Labeled Radioimmunoconjugate for Dual-Modal (PET/NIRF) Imaging of MT1-MMP in Sarcomas
TA Pringle, CD Chan, S Luli, HJ Blair, KS Rankin, JC Knight
Bioconjugate chemistry 33 (8), 1564-1573, 2022
112022
Mutation of the RelA (p65) Thr505 phosphosite disrupts the DNA replication stress response leading to CHK1 inhibitor resistance
JE Hunter, AE Campbell, JA Butterworth, H Sellier, NL Hannaway, S Luli, ...
Biochemical Journal 479 (19), 2087-2113, 2022
82022
Homodimeric Minimal Factor H: In Vivo Tracking and Extended Dosing Studies in Factor H Deficient Mice
O Kamala, TH Malik, TM Hallam, TE Cox, Y Yang, F Vyas, S Luli, ...
Frontiers in Immunology 12, 752916, 2021
82021
Non-invasive synchronous monitoring of neutrophil migration using whole body near-infrared fluorescence-based imaging
J Leslie, SM Robinson, F Oakley, S Luli
Scientific Reports 11 (1), 1415, 2021
82021
Enhanced in vivo Optical Imaging of the Inflammatory Response to Acute Liver Injury in C57BL/6 Mice Using a Highly Bright Near‐Infrared BODIPY Dye
D Sirbu, S Luli, J Leslie, F Oakley, AC Benniston
ChemMedChem 14 (10), 995-999, 2019
82019
Regulation of CHK1 inhibitor resistance by a c-Rel and USP1 dependent pathway
JE Hunter, AE Campbell, NL Hannaway, S Kerridge, S Luli, ...
Biochemical Journal 479 (19), 2063-2086, 2022
72022
Anti–cholestatic therapy with obeticholic acid improves short-term memory in bile duct–ligated mice
LMV Gee, B Barron-Millar, J Leslie, C Richardson, MYW Zaki, S Luli, ...
The American Journal of Pathology 193 (1), 11-26, 2023
62023
Up-regulation of the PI3K/AKT and RHO/RAC/PAK signalling pathways in CHK1 inhibitor resistant Eµ-Myc lymphoma cells
JE Hunter, AE Campbell, S Kerridge, C Fraser, NL Hannaway, S Luli, ...
Biochemical Journal 479 (19), 2131-2151, 2022
52022
Regulation of checkpoint kinase signalling and tumorigenesis by the NF-κB regulated gene, CLSPN
JE Hunter, JA Butterworth, H Sellier, S Luli, A Floudas, AJ Moore, ...
BioRxiv, 358291, 2018
42018
Impact of retrotransposon protein L1 ORF1p expression on oncogenic pathways in hepatocellular carcinoma: the role of cytoplasmic PIN1 upregulation
B Zadran, PD Sudhindar, D Wainwright, Y Bury, S Luli, R Howarth, ...
British Journal of Cancer 128 (7), 1236-1248, 2023
32023
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