| Cryo-EM of full-length α-synuclein reveals fibril polymorphs with a common structural kernel B Li, P Ge, KA Murray, P Sheth, M Zhang, G Nair, MR Sawaya, WS Shin, ... Nature communications 9 (1), 3609, 2018 | 548 | 2018 |
| Atomic structures of low-complexity protein segments reveal kinked β sheets that assemble networks MP Hughes, MR Sawaya, DR Boyer, L Goldschmidt, JA Rodriguez, ... Science 359 (6376), 698-701, 2018 | 404 | 2018 |
| Structure-based inhibitors of tau aggregation PM Seidler, DR Boyer, JA Rodriguez, MR Sawaya, D Cascio, K Murray, ... Nature chemistry 10 (2), 170-176, 2018 | 277 | 2018 |
| Cryo-EM structures of four polymorphic TDP-43 amyloid cores Q Cao, DR Boyer, MR Sawaya, P Ge, DS Eisenberg Nature structural & molecular biology 26 (7), 619-627, 2019 | 212 | 2019 |
| Atomic structures of TDP-43 LCD segments and insights into reversible or pathogenic aggregation EL Guenther, Q Cao, H Trinh, J Lu, MR Sawaya, D Cascio, DR Boyer, ... Nature structural & molecular biology 25 (6), 463-471, 2018 | 204 | 2018 |
| The α-synuclein hereditary mutation E46K unlocks a more stable, pathogenic fibril structure DR Boyer, B Li, C Sun, W Fan, K Zhou, MP Hughes, MR Sawaya, L Jiang, ... Proceedings of the National Academy of Sciences 117 (7), 3592-3602, 2020 | 143 | 2020 |
| Structures of fibrils formed by α-synuclein hereditary disease mutant H50Q reveal new polymorphs DR Boyer, B Li, C Sun, W Fan, MR Sawaya, L Jiang, DS Eisenberg Nature structural & molecular biology 26 (11), 1044-1052, 2019 | 142 | 2019 |
| Cryo-EM structure and inhibitor design of human IAPP (amylin) fibrils Q Cao, DR Boyer, MR Sawaya, P Ge, DS Eisenberg Nature structural & molecular biology 27 (7), 653-659, 2020 | 108 | 2020 |
| Isofunctional enzymes PAD1 and UbiX catalyze formation of a novel cofactor required by ferulic acid decarboxylase and 4-hydroxy-3-polyprenylbenzoic acid decarboxylase F Lin, KL Ferguson, DR Boyer, XN Lin, ENG Marsh ACS chemical biology 10 (4), 1137-1144, 2015 | 102 | 2015 |
| Atomic-level evidence for packing and positional amyloid polymorphism by segment from TDP-43 RRM2 EL Guenther, P Ge, H Trinh, MR Sawaya, D Cascio, DR Boyer, T Gonen, ... Nature structural & molecular biology 25 (4), 311-319, 2018 | 99 | 2018 |
| Sub-ångström cryo-EM structure of a prion protofibril reveals a polar clasp M Gallagher-Jones, C Glynn, DR Boyer, MW Martynowycz, E Hernandez, ... Nature structural & molecular biology 25 (2), 131-134, 2018 | 90 | 2018 |
| CryoEM structure of the low-complexity domain of hnRNPA2 and its conversion to pathogenic amyloid J Lu, Q Cao, MP Hughes, MR Sawaya, DR Boyer, D Cascio, ... Nature communications 11 (1), 4090, 2020 | 84 | 2020 |
| Structure-based discovery of small molecules that disaggregate Alzheimer’s disease tissue derived tau fibrils in vitro PM Seidler, KA Murray, DR Boyer, P Ge, MR Sawaya, CJ Hu, X Cheng, ... Nature communications 13 (1), 5451, 2022 | 77 | 2022 |
| Structure-based inhibitors halt prion-like seeding by Alzheimer’s disease–and tauopathy–derived brain tissue samples PM Seidler, DR Boyer, KA Murray, TP Yang, M Bentzel, MR Sawaya, ... Journal of Biological Chemistry 294 (44), 16451-16464, 2019 | 59 | 2019 |
| Nanoscale mosaicity revealed in peptide microcrystals by scanning electron nanodiffraction M Gallagher-Jones, C Ophus, KC Bustillo, DR Boyer, O Panova, C Glynn, ... Communications biology 2 (1), 26, 2019 | 53 | 2019 |
| Structure of amyloid-β (20-34) with Alzheimer’s-associated isomerization at Asp23 reveals a distinct protofilament interface RA Warmack, DR Boyer, CT Zee, LS Richards, MR Sawaya, D Cascio, ... Nature communications 10 (1), 3357, 2019 | 47 | 2019 |
| Cryo-EM structures of hIAPP fibrils seeded by patient-extracted fibrils reveal new polymorphs and conserved fibril cores Q Cao, DR Boyer, MR Sawaya, R Abskharon, L Saelices, BA Nguyen, ... Nature structural & molecular biology 28 (9), 724-730, 2021 | 46 | 2021 |
| Intrinsic electronic conductivity of individual atomically resolved amyloid crystals reveals micrometer-long hole hopping via tyrosines C Shipps, HR Kelly, PJ Dahl, SM Yi, D Vu, D Boyer, C Glynn, MR Sawaya, ... Proceedings of the National Academy of Sciences 118 (2), e2014139118, 2021 | 44 | 2021 |
| Cryo-EM structure of RNA-induced tau fibrils reveals a small C-terminal core that may nucleate fibril formation R Abskharon, MR Sawaya, DR Boyer, Q Cao, BA Nguyen, D Cascio, ... Proceedings of the National Academy of Sciences 119 (15), e2119952119, 2022 | 40 | 2022 |
| Inhibition of amyloid formation of the Nucleoprotein of SARS-CoV-2 E Tayeb-Fligelman, X Cheng, C Tai, JT Bowler, S Griner, MR Sawaya, ... BioRxiv, 2021.03. 05.434000, 2021 | 19 | 2021 |
David S. EisenbergPaul Boyer Professor, HHMI-UCLAVerified email at mbi.ucla.edu
