Direct reductive amination of aldehydes and ketones using phenylsilane: catalysis by dibutyltin dichloride R Apodaca, W Xiao Organic letters 3 (11), 1745-1748, 2001 | 201 | 2001 |
Acute wake‐promoting actions of JNJ‐5207852, a novel, diamine‐based H3 antagonist AJ Barbier, C Berridge, C Dugovic, AD Laposky, SJ Wilson, J Boggs, ... British journal of pharmacology 143 (5), 649-661, 2004 | 196 | 2004 |
A new class of diamine-based human histamine H3 receptor antagonists: 4-(aminoalkoxy) benzylamines R Apodaca, CA Dvorak, W Xiao, AJ Barbier, JD Boggs, SJ Wilson, ... Journal of medicinal chemistry 46 (18), 3938-3944, 2003 | 140 | 2003 |
Thiadiazolopiperazinyl ureas as inhibitors of fatty acid amide hydrolase JM Keith, R Apodaca, W Xiao, M Seierstad, K Pattabiraman, J Wu, ... Bioorganic & medicinal chemistry letters 18 (17), 4838-4843, 2008 | 101 | 2008 |
Potent and selective α-ketoheterocycle-based inhibitors of the anandamide and oleamide catabolizing enzyme, fatty acid amide hydrolase FA Romero, W Du, I Hwang, TJ Rayl, FS Kimball, D Leung, HS Hoover, ... Journal of medicinal chemistry 50 (5), 1058-1068, 2007 | 90 | 2007 |
Biochemical and biological properties of 4-(3-phenyl-[1, 2, 4] thiadiazol-5-yl)-piperazine-1-carboxylic acid phenylamide, a mechanism-based inhibitor of fatty acid amide hydrolase MJ Karbarz, L Luo, L Chang, CS Tham, JA Palmer, SJ Wilson, ... Anesthesia & Analgesia 108 (1), 316-329, 2009 | 82 | 2009 |
4-Phenoxypiperidines: Potent, Conformationally Restricted, Non-Imidazole Histamine H3 Antagonists CA Dvorak, R Apodaca, AJ Barbier, CW Berridge, SJ Wilson, JD Boggs, ... Journal of medicinal chemistry 48 (6), 2229-2238, 2005 | 81 | 2005 |
Lead identification of acetylcholinesterase inhibitors–histamine H3 receptor antagonists from molecular modeling SD Bembenek, JM Keith, MA Letavic, R Apodaca, AJ Barbier, L Dvorak, ... Bioorganic & medicinal chemistry 16 (6), 2968-2973, 2008 | 76 | 2008 |
N-heteroarylpiperazinyl ureas as modulators of fatty acid amide hydrolase R Apodaca, JG Breitenbucher, K Pattabiraman, M Seierstad, W Xiao US Patent 7,541,359, 2009 | 66* | 2009 |
Trimethylsilylcyanation of aldehydes and ketones catalyzed by diorganotin dichlorides JK Whitesell, R Apodaca Tetrahedron letters 37 (15), 2525-2528, 1996 | 66 | 1996 |
Aryl piperazinyl ureas as inhibitors of fatty acid amide hydrolase (FAAH) in rat, dog, and primate JM Keith, R Apodaca, M Tichenor, W Xiao, W Jones, J Pierce, M Seierstad, ... ACS medicinal chemistry letters 3 (10), 823-827, 2012 | 43 | 2012 |
Aplysamine-1 and related analogs as histamine H3 receptor antagonists DM Swanson, SJ Wilson, JD Boggs, W Xiao, R Apodaca, AJ Barbier, ... Bioorganic & medicinal chemistry letters 16 (4), 897-900, 2006 | 37 | 2006 |
Novel ketooxazole based inhibitors of fatty acid amide hydrolase (FAAH) A Timmons, M Seierstad, R Apodaca, M Epperson, D Pippel, S Brown, ... Bioorganic & medicinal chemistry letters 18 (6), 2109-2113, 2008 | 32 | 2008 |
Heterocyclic replacement of the central phenyl core of diamine-based histamine H3 receptor antagonists DM Swanson, CR Shah, B Lord, K Morton, LK Dvorak, C Mazur, ... European journal of medicinal chemistry 44 (11), 4413-4425, 2009 | 29 | 2009 |
Non-imidazole aryloxypiperidines R Apodaca, NI Carruthers, CA Dvorak, CR Shah, W Xiao US Patent 7,071,191, 2006 | 24 | 2006 |
A convenient synthesis of protected and free homoallylic alcohols: Catalytic use of dibutyltin dichloride in the allylation of aldehydes with allyltributyltin JK Whitesell, R Apodaca Tetrahedron letters 37 (23), 3955-3958, 1996 | 22 | 1996 |
Piperazinyl and diazapanyl benzamides and benzthioamides RL Apodaca, JA Jablonowski, KS Ly, CR Shah, DM Swanson, W Xiao US Patent 7,414,047, 2008 | 21 | 2008 |
2-Keto-Oxazoles as Modulators of Fatty Acid Amide Hydrolase R Apodaca, JG Breitenbucher, MT Epperson, AK Fried, DJ Pippel, ... US Patent App. 12/094,139, 2009 | 20* | 2009 |
Novel benzamide-based histamine H3 receptor antagonists: the identification of two candidates for clinical development MA Letavic, L Aluisio, R Apodaca, M Bajpai, AJ Barbier, A Bonneville, ... ACS Medicinal Chemistry Letters 6 (4), 450-454, 2015 | 19 | 2015 |
Aryl-hydroxyethylamino-pyrimidines and triazines as modulators of fatty acid amide hydrolase R Apodaca, JG Breitenbucher, AL Chambers, X Deng, NA Hawryluk, ... US Patent 8,598,202, 2013 | 18 | 2013 |