Obesity-induced inflammation and desmoplasia promote pancreatic cancer progression and resistance to chemotherapy J Incio, H Liu, P Suboj, SM Chin, IX Chen, M Pinter, MR Ng, HT Nia, ... Cancer discovery 6 (8), 852-869, 2016 | 367 | 2016 |
Blocking CXCR4 alleviates desmoplasia, increases T-lymphocyte infiltration, and improves immunotherapy in metastatic breast cancer IX Chen, VP Chauhan, J Posada, MR Ng, MW Wu, P Adstamongkonkul, ... Proceedings of the National Academy of Sciences 116 (10), 4558-4566, 2019 | 309 | 2019 |
Dual programmed death receptor‐1 and vascular endothelial growth factor receptor‐2 blockade promotes vascular normalization and enhances antitumor immune responses in … K Shigeta, M Datta, T Hato, S Kitahara, IX Chen, A Matsui, H Kikuchi, ... Hepatology 71 (4), 1247-1261, 2020 | 291 | 2020 |
Anti-VEGF therapy induces ECM remodeling and mechanical barriers to therapy in colorectal cancer liver metastases NN Rahbari, D Kedrin, J Incio, H Liu, WW Ho, HT Nia, CM Edrich, K Jung, ... Science translational medicine 8 (360), 360ra135-360ra135, 2016 | 215 | 2016 |
A glial signature and Wnt7 signaling regulate glioma-vascular interactions and tumor microenvironment A Griveau, G Seano, SJ Shelton, R Kupp, A Jahangiri, K Obernier, ... Cancer cell 33 (5), 874-889. e7, 2018 | 205 | 2018 |
Reprogramming the microenvironment with tumor-selective angiotensin blockers enhances cancer immunotherapy VP Chauhan, IX Chen, R Tong, MR Ng, JD Martin, K Naxerova, MW Wu, ... Proceedings of the National Academy of Sciences 116 (22), 10674-10680, 2019 | 167 | 2019 |
Fatty acid synthesis is required for breast cancer brain metastasis GB Ferraro, A Ali, A Luengo, DP Kodack, A Deik, KL Abbott, D Bezwada, ... Nature cancer 2 (4), 414-428, 2021 | 165 | 2021 |
Metformin reduces desmoplasia in pancreatic cancer by reprogramming stellate cells and tumor-associated macrophages J Incio, P Suboj, SM Chin, T Vardam-Kaur, H Liu, T Hato, S Babykutty, ... PloS one 10 (12), e0141392, 2015 | 137 | 2015 |
Regorafenib combined with PD1 blockade increases CD8 T-cell infiltration by inducing CXCL10 expression in hepatocellular carcinoma K Shigeta, A Matsui, H Kikuchi, S Klein, E Mamessier, IX Chen, S Aoki, ... Journal for immunotherapy of cancer 8 (2), 2020 | 101 | 2020 |
Antibody-mediated delivery of viral epitopes to tumors harnesses CMV-specific T cells for cancer therapy DG Millar, RR Ramjiawan, K Kawaguchi, N Gupta, J Chen, S Zhang, ... Nature biotechnology 38 (4), 420-425, 2020 | 58 | 2020 |
Spatiotemporal effects of a controlled-release anti-inflammatory drug on the cellular dynamics of host response TT Dang, KM Bratlie, SR Bogatyrev, XY Chen, R Langer, DG Anderson Biomaterials 32 (19), 4464-4470, 2011 | 52 | 2011 |
Dendritic cell paucity in mismatch repair–proficient colorectal cancer liver metastases limits immune checkpoint blockade efficacy WW Ho, IL Gomes-Santos, S Aoki, M Datta, K Kawaguchi, NP Talele, ... Proceedings of the National Academy of Sciences 118 (45), e2105323118, 2021 | 49 | 2021 |
Solid stress impairs lymphocyte infiltration into lymph-node metastases D Jones, Z Wang, IX Chen, S Zhang, R Banerji, PJ Lei, H Zhou, V Xiao, ... Nature biomedical engineering 5 (12), 1426-1436, 2021 | 44 | 2021 |
A bilateral tumor model identifies transcriptional programs associated with patient response to immune checkpoint blockade IX Chen, K Newcomer, KE Pauken, VR Juneja, K Naxerova, MW Wu, ... Proceedings of the National Academy of Sciences 117 (38), 23684-23694, 2020 | 42 | 2020 |
Non-invasive monitoring of chronic liver disease via near-infrared and shortwave-infrared imaging of endogenous lipofuscin M Saif, WJ Kwanten, JA Carr, IX Chen, JM Posada, A Srivastava, J Zhang, ... Nature biomedical engineering 4 (8), 801-813, 2020 | 41 | 2020 |
Placental growth factor promotes tumour desmoplasia and treatment resistance in intrahepatic cholangiocarcinoma S Aoki, K Inoue, S Klein, S Halvorsen, J Chen, A Matsui, MR Nikmaneshi, ... Gut 71 (1), 185-193, 2022 | 38 | 2022 |
Microfabrication of homogenous, asymmetric cell-laden hydrogel capsules TT Dang, Q Xu, KM Bratlie, ES O'Sullivan, XY Chen, R Langer, ... Biomaterials 30 (36), 6896-6902, 2009 | 37 | 2009 |
Obesity-Induced Inflammation and Desmoplasia Promote Pancreatic Cancer Progression and Resistance to Chemotherapy. Cancer Discov 6, 852–869, doi: 10.1158/2159-8290 J Incio, H Liu, P Suboj, SM Chin, IX Chen, M Pinter, MR Ng, HT Nia, ... Int J Cancer 120 (12), 2665-2671, 2016 | 24 | 2016 |
Combining losartan with radiotherapy increases tumor control and inhibits lung metastases from a HER2/neu-positive orthotopic breast cancer model W Li, S Li, IX Chen, Y Liu, RR Ramjiawan, CH Leung, LE Gerweck, ... Radiation Oncology 16, 1-12, 2021 | 22 | 2021 |
Losartan controls immune checkpoint blocker-induced edema and improves survival in glioblastoma mouse models M Datta, S Chatterjee, EM Perez, S Gritsch, S Roberge, M Duquette, ... Proceedings of the National Academy of Sciences 120 (6), e2219199120, 2023 | 17 | 2023 |