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Mengbin Chen
Mengbin Chen
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Year
SAM-dependent enzyme-catalysed pericyclic reactions in natural product biosynthesis
M Ohashi, F Liu, Y Hai, M Chen, M Tang, Z Yang, M Sato, K Watanabe, ...
Nature 549 (7673), 502-506, 2017
1652017
Mechanistic insights from the binding of substrate and carbocation intermediate analogues to aristolochene synthase
M Chen, N Al-Lami, M Janvier, EL D’Antonio, JA Faraldos, DE Cane, ...
Biochemistry 52 (32), 5441-5453, 2013
742013
Structure and Function of Fusicoccadiene Synthase, a Hexameric Bifunctional Diterpene Synthase
M Chen, WKW Chou, T Toyomasu, DE Cane, DW Christianson
ACS chemical biology 11, 889-899, 2016
672016
Exploring the Influence of Domain Architecture on the Catalytic Function of Diterpene Synthases
TA Pemberton, M Chen, GG Harris, WKW Chou, L Duan, M Köksal, ...
Biochemistry 56 (14), 2010-2023, 2017
662017
Genome mining and biosynthesis of a polyketide from a biofertilizer fungus that can facilitate reductive iron assimilation in plant
M Chen, Q Liu, SS Gao, AE Young, SE Jacobsen, Y Tang
Proceedings of the National Academy of Sciences of the United States of America, 2019
482019
Genome Mining of Alkaloidal Terpenoids from a Hybrid Terpene and Nonribosomal Peptide Biosynthetic Pathway
DA Yee, TB Kakule, W Cheng, M Chen, CTY Chong, Y Hai, LF Hang, ...
Journal of the American Chemical Society 142 (2), 710-714, 2019
472019
Discovery and Biocatalytic Application of a PLP-Dependent Amino Acid γ-Substitution Enzyme that Catalyzes CC Bond Formation
M Chen, CT Liu, Y Tang
Journal of the American Chemical Society, 2020
432020
Biosynthesis of Mycotoxin Fusaric Acid and Application of a PLP-Dependent Enzyme for Chemoenzymatic Synthesis of Substituted l-Pipecolic Acids
Y Hai, M Chen, A Huang, Y Tang
Journal of the American Chemical Society 142 (46), 19668-19677, 2020
382020
Mechanism of germacradien-4-ol synthase controlled water capture
DJ Grundy, M Chen, V Gonzalez, S Leoni, DJ Miller, DW Christianson, ...
Biochemistry, 2016
372016
Multi-domain terpenoid cyclase architecture and prospects for proximity in bifunctional catalysis
M Chen, GG Harris, TA Pemberton, DW Christianson
Current Opinion in Structural Biology 41, 27-37, 2016
352016
Harzianic Acid from Trichoderma afroharzianum Is a Natural Product Inhibitor of Acetohydroxyacid Synthase
L Xie, X Zang, W Cheng, Z Zhang, J Zhou, M Chen, Y Tang
Journal of the American Chemical Society, 2021
332021
Genome mining for unknown–unknown natural products
DA Yee, K Niwa, B Perlatti, M Chen, Y Li, Y Tang
Nature chemical biology 19 (5), 633-640, 2023
302023
Probing the Role of Active Site Water in the Sesquiterpene Cyclization Reaction Catalyzed by Aristolochene Synthase
M Chen, WKW Chou, N Al-Lami, JA Faraldos, RK Allemann, DE Cane, ...
Biochemistry 55 (20), 2864-2874, 2016
262016
High-Titer Production of Olivetolic Acid and Analogs in Engineered Fungal Host Using a Nonplant Biosynthetic Pathway
IC Okorafor, M Chen, Y Tang
ACS synthetic biology 10 (9), 2159-2166, 2021
212021
Genome mining of cryptic tetronate natural products from a PKS-NRPS encoding gene cluster in Trichoderma harzianum t-22
Y Zhu, J Wang, P Mou, Y Yan, M Chen, Y Tang
Organic & Biomolecular Chemistry 19 (9), 1985-1990, 2021
202021
Biosynthesis of Terpenoid–Pyrrolobenzoxazine Hybrid Natural Product CJ‐12662
W Cheng, M Chen, M Ohashi, Y Tang
Angewandte Chemie 134 (12), e202116928, 2022
122022
Flow-injection with enhanced evaporative light scattering detector detection and quantification of human serum albumin using gold nanoparticles
T Wang, M Chen, C Niu, N Liu, L Wang, B Sun, W Hua, J Ouyang
Analytical Methods 7 (7), 3185-3192, 2015
72015
Unleashing the Power of Biocatalysts
M Chen
ChemBioChem 22 (2), 317-318, 2021
2021
Biosynthetic platform for the production of olivetolic avid and analogues of olivetolic acid
Y Tang, M Chen, I Okorafor
WO Patent WO2021142393A1, 2021
2021
Structure and function of fusicoccadiene synthase, a bifunctional diterpene synthase with an alpha-alpha fold
M Chen, D Christianson
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY 251, 2016
2016
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Articles 1–20