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Jean-Pierre Issa
Jean-Pierre Issa
Coriell Institute for Medical Research
Verified email at coriell.org - Homepage
Title
Cited by
Cited by
Year
CpG island methylator phenotype in colorectal cancer
M Toyota, N Ahuja, M Ohe-Toyota, JG Herman, SB Baylin, JPJ Issa
Proceedings of the National Academy of Sciences 96 (15), 8681-8686, 1999
30881999
Alterations in DNA methylation: a fundamental aspect of neoplasia
SB Baylln, JG Herman, JR Graff, PM Vertino, JP Issa
Advances in cancer research 72, 141-196, 1997
25931997
Incidence and functional consequences of hMLH1 promoter hypermethylation in colorectal carcinoma
JG Herman, A Umar, K Polyak, JR Graff, N Ahuja, JPJ Issa, S Markowitz, ...
Proceedings of the National Academy of Sciences 95 (12), 6870-6875, 1998
24211998
Inactivation of the CDKN2/p16/MTS1 Gene Is Frequently Associated with Aberrant DNA Methylation in All Common Human Cancers
JG Herman, A Merlo, LI Mao, RG Lapidus, JPJ Issa, NE Davidson, ...
Cancer research 55 (20), 4525-4530, 1995
19541995
Decitabine improves patient outcomes in myelodysplastic syndromes: results of a phase III randomized study
H Kantarjian, JPJ Issa, CS Rosenfeld, JM Bennett, M Albitar, J DiPersio, ...
Cancer: Interdisciplinary International Journal of the American Cancer …, 2006
18922006
Methylation of the oestrogen receptor CpG island links ageing and neoplasia in human colon
JPJ Issa, YL Ottaviano, P Celano, SR Hamilton, NE Davidson, SB Baylin
Nature genetics 7 (4), 536-540, 1994
14511994
CpG island methylator phenotype in cancer
JP Issa
Nature Reviews Cancer 4 (12), 988-993, 2004
13762004
Dnmt3a is essential for hematopoietic stem cell differentiation
GA Challen, D Sun, M Jeong, M Luo, J Jelinek, JS Berg, C Bock, ...
Nature genetics 44 (1), 23-31, 2012
12432012
A simple method for estimating global DNA methylation using bisulfite PCR of repetitive DNA elements
AS Yang, MRH Estécio, K Doshi, Y Kondo, EH Tajara, JPJ Issa
Nucleic acids research 32 (3), e38-e38, 2004
11542004
Targeting the cancer epigenome for therapy
PA Jones, JPJ Issa, S Baylin
Nature Reviews Genetics 17 (10), 630-641, 2016
11212016
Phase 1 study of low-dose prolonged exposure schedules of the hypomethylating agent 5-aza-2′-deoxycytidine (decitabine) in hematopoietic malignancies
JPJ Issa, G Garcia-Manero, FJ Giles, R Mannari, D Thomas, S Faderl, ...
Blood 103 (5), 1635-1640, 2004
10242004
Results of a randomized study of 3 schedules of low-dose decitabine in higher-risk myelodysplastic syndrome and chronic myelomonocytic leukemia
H Kantarjian, Y Oki, G Garcia-Manero, X Huang, S O'Brien, J Cortes, ...
Blood 109 (1), 52-57, 2007
9552007
Aging and DNA methylation in colorectal mucosa and cancer
N Ahuja, Q Li, AL Mohan, SB Baylin, JPJ Issa
Cancer research 58 (23), 5489-5494, 1998
7781998
Accelerated age-related CpG island methylation in ulcerative colitis
JPJ Issa, N Ahuja, M Toyota, MP Bronner, TA Brentnall
Cancer research 61 (9), 3573-3577, 2001
7582001
Phase II pilot study of vemurafenib in patients with metastatic BRAF-mutated colorectal cancer
S Kopetz, J Desai, E Chan, JR Hecht, PJ O'Dwyer, D Maru, V Morris, ...
Journal of clinical oncology 33 (34), 4032, 2015
7212015
Gene silencing in cancer by histone H3 lysine 27 trimethylation independent of promoter DNA methylation
Y Kondo, L Shen, AS Cheng, S Ahmed, Y Boumber, C Charo, T Yamochi, ...
Nature genetics 40 (6), 741-750, 2008
7042008
Integrated genetic and epigenetic analysis identifies three different subclasses of colon cancer
L Shen, M Toyota, Y Kondo, E Lin, L Zhang, Y Guo, NS Hernandez, ...
Proceedings of the National Academy of Sciences 104 (47), 18654-18659, 2007
6942007
Transient low doses of DNA-demethylating agents exert durable antitumor effects on hematological and epithelial tumor cells
HC Tsai, H Li, L Van Neste, Y Cai, C Robert, FV Rassool, JJ Shin, ...
Cancer cell 21 (3), 430-446, 2012
6822012
Inactivation of the DNA Repair Gene O6-Methylguanine-DNA Methyltransferase by Promoter Hypermethylation Is Associated with G to A Mutations in K-ras in …
M Esteller, M Toyota, M Sanchez-Cespedes, G Capella, MA Peinado, ...
Cancer research 60 (9), 2368-2371, 2000
6742000
Aberrant methylation in gastric cancer associated with the CpG island methylator phenotype
M Toyota, N Ahuja, H Suzuki, F Itoh, M Ohe-Toyota, K Imai, SB Baylin, ...
Cancer research 59 (21), 5438-5442, 1999
6651999
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