How allosteric control of Staphylococcus aureus penicillin binding protein 2a enables methicillin resistance and physiological function LH Otero, A Rojas-Altuve, LI Llarrull, C Carrasco-López, M Kumarasiri, ... Proceedings of the National Academy of Sciences 110 (42), 16808-16813, 2013 | 294 | 2013 |
Discovery of Antibiotic (E)-3-(3-Carboxyphenyl)-2-(4-cyanostyryl)quinazolin-4(3H)-one R Bouley, M Kumarasiri, Z Peng, LH Otero, W Song, MA Suckow, ... Journal of the American Chemical Society 137 (5), 1738-1741, 2015 | 137 | 2015 |
Disruption of allosteric response as an unprecedented mechanism of resistance to antibiotics J Fishovitz, A Rojas-Altuve, LH Otero, M Dawley, C Carrasco-López, ... Journal of the American Chemical Society 136 (28), 9814-9817, 2014 | 91 | 2014 |
Structural basis for the broad specificity of a new family of amino-acid racemases A Espaillat, C Carrasco-López, N Bernardo-García, N Pietrosemoli, ... Acta Crystallographica Section D: Biological Crystallography 70 (1), 79-90, 2014 | 81 | 2014 |
Development of a hyperimmune equine serum therapy for COVID-19 in Argentina V Zylberman, S Sanguineti, AV Pontoriero, SV Higa, ML Cerutti, ... Medicina (Buenos Aires) 80, 1-6, 2020 | 77 | 2020 |
Structure of the full-length bacteriophytochrome from the plant pathogen Xanthomonas campestris provides clues to its long-range signaling mechanism LH Otero, S Klinke, J Rinaldi, F Velázquez-Escobar, MA Mroginski, ... Journal of molecular biology 428 (19), 3702-3720, 2016 | 74 | 2016 |
The disruptive effect of lysozyme on the bacterial cell wall explored by an in‐silico structural outlook ED Primo, LH Otero, F Ruiz, S Klinke, W Giordano Biochemistry and Molecular Biology Education 46 (1), 83-90, 2018 | 57 | 2018 |
The reaction mechanism of metallo-β-lactamases is tuned by the conformation of an active-site mobile loop AR Palacios, MF Mojica, E Giannini, MA Taracila, CR Bethel, PM Alzari, ... Antimicrobial agents and chemotherapy 63 (1), 10.1128/aac. 01754-18, 2019 | 31 | 2019 |
A Pseudomonas aeruginosa PAO1 acetylcholinesterase is encoded by the PA4921 gene and belongs to the SGNH hydrolase family DG Sánchez, LH Otero, CM Hernández, AL Serra, S Encarnación, ... Microbiological research 167 (6), 317-325, 2012 | 25 | 2012 |
Snapshots of conformational changes shed light into the NtrX receiver domain signal transduction mechanism I Fernández, LH Otero, S Klinke, M del Carmen Carrica, FA Goldbaum Journal of Molecular Biology 427 (20), 3258-3272, 2015 | 19 | 2015 |
Critical Active-Site Residues Identified by Site-Directed Mutagenesis in Pseudomonas aeruginosa Phosphorylcholine Phosphatase, A New Member of the … PR Beassoni, LH Otero, MJ Massimelli, AT Lisa, CE Domenech Current Microbiology 53, 534-539, 2006 | 19 | 2006 |
Using a molecular model and kinetic experiments in the presence of divalent cations to study the active site and catalysis of Pseudomonas aeruginosa phosphorylcholine phosphatase PR Beassoni, LH Otero, AT Lisa, CE Domenech Biochimica et Biophysica Acta (BBA)-Proteins and Proteomics 1784 (12), 2038-2044, 2008 | 17 | 2008 |
A glance on Pseudomonas aeruginosa phosphorylcholine phosphatase, an enzyme whose synthesis depends on the presence of choline in its environment AT Lisa, PR Beassoni, MJ Massimelli, LH Otero, CE Doménech Communicating current research and educational topics and trends in applied …, 2007 | 16 | 2007 |
Crystallization and preliminary X-ray characterization of the full-length bacteriophytochrome from the plant pathogen Xanthomonas campestris pv. campestris S Klinke, LH Otero, J Rinaldi, S Sosa, BG Guimarães, WE Shepard, ... Acta Crystallographica Section F: Structural Biology Communications 70 (12 …, 2014 | 14 | 2014 |
Structural basis for the Pr-Pfr long-range signaling mechanism of a full-length bacterial phytochrome at the atomic level LH Otero, S Foscaldi, GT Antelo, GL Rosano, S Sirigu, S Klinke, ... Science Advances 7, eabh1097 - eabh1097, 2021 | 12 | 2021 |
Dimer Asymmetry and Light Activation Mechanism in Brucella Blue-Light Sensor Histidine Kinase J Rinaldi, I Fernández, H Shin, G Sycz, S Gunawardana, ... MBio 12 (2), 10.1128/mbio. 00264-21, 2021 | 11 | 2021 |
Solution and crystal structure of BA42, a protein from the Antarctic bacterium Bizionia argentinensis comprised of a stand‐alone TPM domain M Aran, C Smal, L Pellizza, M Gallo, LH Otero, S Klinke, FA Goldbaum, ... Proteins: Structure, Function, and Bioinformatics 82 (11), 3062-3078, 2014 | 11 | 2014 |
Phosphorylcholine phosphatase: a peculiar enzyme of Pseudomonas aeruginosa CE Domenech, LH Otero, PR Beassoni, AT Lisa Enzyme Research 2011, 2011 | 11 | 2011 |
Transition from octahedral to tetrahedral geometry causes the activation or inhibition by Zn2+ of Pseudomonas aeruginosa phosphorylcholine phosphatase LH Otero, PR Beassoni, AT Lisa, CE Domenech BioMetals 23 (2), 307-314, 2010 | 11 | 2010 |
Clinical characteristics of vulnerable populations hospitalized and diagnosed with COVID-19 in Buenos Aires, Argentina A Yacobitti, L Otero, V Doldan Arrubarrena, J Arano, S Lage, M Silberman, ... Scientific reports 11 (1), 9679, 2021 | 9 | 2021 |