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Laura Siles Mena
Laura Siles Mena
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Year
EMT-activating transcription factors in cancer: beyond EMT and tumor invasiveness
E Sánchez-Tilló, Y Liu, O de Barrios, L Siles, L Fanlo, M Cuatrecasas, ...
Cellular and molecular life sciences 69, 3429-3456, 2012
5842012
β-catenin/TCF4 complex induces the epithelial-to-mesenchymal transition (EMT)-activator ZEB1 to regulate tumor invasiveness
E Sánchez-Tilló, O de Barrios, L Siles, M Cuatrecasas, A Castells, ...
Proceedings of the National Academy of Sciences 108 (48), 19204-19209, 2011
4572011
Expanding roles of ZEB factors in tumorigenesis and tumor progression
E Sánchez-Tilló, L Siles, O De Barrios, M Cuatrecasas, EC Vaquero, ...
American journal of cancer research 1 (7), 897, 2011
2082011
The EMT activator ZEB1 promotes tumor growth and determines differential response to chemotherapy in mantle cell lymphoma
E Sanchez-Tillo, L Fanlo, L Siles, S Montes-Moreno, A Moros, ...
Cell Death & Differentiation 21 (2), 247-257, 2014
1262014
ZEB1 Promotes invasiveness of colorectal carcinoma cells through the opposing regulation of uPA and PAI-1
E Sánchez-Tilló, O de Barrios, L Siles, PG Amendola, DS Darling, ...
Clinical cancer research 19 (5), 1071-1082, 2013
732013
ZEB1 imposes a temporary stage-dependent inhibition of muscle gene expression and differentiation via CtBP-mediated transcriptional repression
L Siles, E Sánchez-Tilló, JW Lim, DS Darling, KL Kroll, A Postigo
Molecular and cellular biology, 2013
542013
ZEB1-induced tumourigenesis requires senescence inhibition via activation of DKK1/mutant p53/Mdm2/CtBP and repression of macroH2A1
O De Barrios, B Győrffy, MJ Fernández-Aceńero, E Sánchez-Tilló, ...
Gut 66 (4), 666-682, 2017
472017
ZEB1 protects skeletal muscle from damage and is required for its regeneration
L Siles, C Ninfali, M Cortés, DS Darling, A Postigo
Nature Communications 10 (1), 1364, 2019
462019
ZEB1 promotes inflammation and progression towards inflammation-driven carcinoma through repression of the DNA repair glycosylase MPG in epithelial cells
O de Barrios, L Sanchez-Moral, M Cortés, C Ninfali, N Profitós-Pelejŕ, ...
Gut 68 (12), 2129-2141, 2019
372019
Regulation of muscle atrophy-related genes by the opposing transcriptional activities of ZEB1/CtBP and FOXO3
C Ninfali, L Siles, DS Darling, A Postigo
Nucleic Acids Research 46 (20), 10697-10708, 2018
362018
Mitotic polarization of transcription factors during asymmetric division establishes fate of forming cancer cells
Y Liu, L Siles, X Lu, KC Dean, M Cuatrecasas, A Postigo, DC Dean
Nature communications 9 (1), 2424, 2018
212018
Efficient correction of ABCA4 variants by CRISPR-Cas9 in hiPSCs derived from Stargardt disease patients
L Siles, S Ruiz-Nogales, A Navinés-Ferrer, P Méndez-Vendrell, ...
Molecular Therapy-Nucleic Acids 32, 64-79, 2023
42023
The EMT factor ZEB1 paradoxically inhibits EMT in BRAF-mutant carcinomas
E Sánchez-Tilló, L Pedrosa, I Vila, Y Chen, B Győrffy, L Sánchez-Moral, ...
JCI insight 8 (20), 2023
32023
High-efficiency CRISPR/Cas9-mediated correction of a homozygous mutation in achromatopsia-patient-derived iPSCs
L Siles, P Gaudó, E Pomares
International Journal of Molecular Sciences 24 (4), 3655, 2023
22023
The mesodermal and myogenic specification of hESCs depend on ZEB1 and are inhibited by ZEB2
C Ninfali, L Siles, A Esteve-Codina, A Postigo
Cell Reports 42 (10), 2023
12023
Epigenetically distinct sister chromatids and asymmetric generation of tumor initiating cells
Y Liu, L Siles, A Postigo, DC Dean
Cell Cycle 17 (18), 2221-2229, 2018
12018
Gene editing for inherited retinal dystrophies: precise correction of pathogenic variants and optimization of the assay design
L Siles, S Ruiz-Nogales, P Mendez, P Gaudo, A Navines-Ferrer, ...
EUROPEAN JOURNAL OF HUMAN GENETICS 32, 306-307, 2024
2024
3 different iPSC-derived cell models for the study of Stargardt Disease and Retinitis Pigmentosa
A Navines-Ferrer, P Mendez, L Siles, P Gaudo, E Pomares
EUROPEAN JOURNAL OF HUMAN GENETICS 32, 113-114, 2024
2024
Three iPSC-derived cell models for the study of Stargardt Disease and Retinitis Pigmentosa.
AN Ferrer, PM Vendrell, L Siles, PG Pardo, E Pomares
Investigative Ophthalmology & Visual Science 64 (8), 5070-5070, 2023
2023
Generation of retinal models from two iPSC lines derived from patients harboring mutations in PDE6A and PDE6C genes.
PG Pardo, A Navinés-Ferrer, PM Vendrell, L Siles, E Pomares
Investigative Ophthalmology & Visual Science 64 (8), 3195-3195, 2023
2023
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