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Sebastian Pomplun
Sebastian Pomplun
Tenure Track Assistant Professor Leiden University LACDR
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Title
Cited by
Cited by
Year
The first-in-class peptide binder to the SARS-CoV-2 spike protein
G Zhang, S Pomplun, AR Loftis, A Loas, BL Pentelute
BioRxiv 10 (2020.03), 19.999318, 2020
1062020
Investigation of ACE2 N-terminal fragments binding to SARS-CoV-2 Spike RBD
G Zhang, S Pomplun, AR Loftis, X Tan, A Loas, BL Pentelute
biorxiv, 2020.03. 19.999318, 2020
952020
De Novo Discovery of High-Affinity Peptide Binders for the SARS-CoV-2 Spike Protein
S Pomplun, M Jbara, AJ Quartararo, G Zhang, JS Brown, YC Lee, X Ye, ...
ACS Central Science 7 (1), 156-163, 2020
732020
Chemogenomic profiling of human and microbial FK506-binding proteins
S Pomplun, C Sippel, A Hähle, D Tay, K Shima, A Klages, CM Ünal, ...
Journal of medicinal chemistry 61 (8), 3660-3673, 2018
642018
Rational Design and Asymmetric Synthesis of Potent and Neurotrophic Ligands for FK506‐Binding Proteins (FKBPs)
S Pomplun, Y Wang, A Kirschner, C Kozany, A Bracher, F Hausch
Angewandte Chemie International Edition 54 (1), 345-348, 2015
412015
Targeting the SARS-CoV-2-spike protein: from antibodies to miniproteins and peptides
S Pomplun
RSC Medicinal Chemistry 12 (2), 197-202, 2021
372021
Recent progress in FKBP ligand development
X Feng, S Pomplun, F Hausch
Current molecular pharmacology 9 (1), 27-36, 2016
272016
Loratadine and Analogues: Discovery and Preliminary Structure–Activity Relationship of Inhibitors of the Amino Acid Transporter B0AT2
S Cuboni, C Devigny, B Hoogeland, A Strasser, S Pomplun, B Hauger, ...
Journal of medicinal chemistry 57 (22), 9473-9479, 2014
262014
Engineering bioactive dimeric transcription factor analogs via palladium rebound reagents
M Jbara, S Pomplun, CK Schissel, SW Hawken, A Boija, I Klein, ...
Journal of the American Chemical Society 143 (30), 11788-11798, 2021
242021
Picomolar FKBP inhibitors enabled by a single water-displacing methyl group in bicyclic [4.3. 1] aza-amides
JM Kolos, S Pomplun, S Jung, B Rieß, PL Purder, AM Voll, S Merz, ...
Chemical science 12 (44), 14758-14765, 2021
232021
Discovery of nucleic acid binding molecules from combinatorial biohybrid nucleobase peptide libraries
S Pomplun, ZP Gates, G Zhang, AJ Quartararo, BL Pentelute
Journal of the American Chemical Society 142 (46), 19642-19651, 2020
232020
Efficient Pictet–Spengler Bioconjugation with N‐Substituted Pyrrolyl Alanine Derivatives
S Pomplun, MYH Mohamed, T Oelschlaegel, C Wellner, F Bergmann
Angewandte Chemie 131 (11), 3580-3585, 2019
232019
Parallel automated flow synthesis of covalent protein complexes that can inhibit MYC-driven transcription
S Pomplun, M Jbara, CK Schissel, S Wilson Hawken, A Boija, C Li, I Klein, ...
ACS Central Science 7 (8), 1408-1418, 2021
192021
Secondary Amino Alcohols: Traceless Cleavable Linkers for Use in Affinity Capture and Release
S Pomplun, CR Shugrue, AM Schmitt, CK Schissel, CE Farquhar, ...
Angewandte Chemie International Edition 59 (28), 11566-11572, 2020
102020
Advances in ultrahigh throughput hit discovery with tandem mass spectrometry encoded libraries
JM Mata, E van der Nol, SJ Pomplun
Journal of the American Chemical Society 145 (34), 19129-19139, 2023
52023
Rationales Design und asymmetrische Synthese potenter neuritotropher Liganden für FK506‐bindende Proteine (FKBPs)
S Pomplun, Y Wang, A Kirschner, C Kozany, A Bracher, F Hausch
Angewandte Chemie 127 (1), 352-355, 2015
52015
Automated flow peptide synthesis enables engineering of proteins with stabilized transient binding pockets
A Charalampidou, T Nehls, C Meyners, S Gandhesiri, S Pomplun, ...
ACS Central Science 10 (3), 649-657, 2024
12024
Use of DNA forceps to measure receptor-ligand dissociation equilibrium constants in a single-molecule competition assay.
F Stransky, D Kostrz, M Follenfant, S Pomplun, C Meyners, T Strick, ...
Methods in Enzymology 694, 51-82, 2024
12024
Synthetic Peptides: Promising Modalities for the Targeting of Disease‐Related Nucleic Acids
BD Ellenbroek, JP Kahler, SR Evers, SJ Pomplun
Angewandte Chemie International Edition, e202401704, 2024
2024
Development of DuoMYC: a synthetic cell penetrant miniprotein that efficiently inhibits the oncogenic transcription factor MYC
S Pomplun, B Ellenbroek, JP Kahler, D Arella, C Lin, W Jespers
bioRxiv, 2024.03. 04.583305, 2024
2024
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