| Structural insights into TDP-43 and effects of post-translational modifications L François-Moutal, S Perez-Miller, DD Scott, VG Miranda, N Mollasalehi, ... Frontiers in molecular neuroscience 12, 301, 2019 | 104 | 2019 |
| A membrane-delimited N-myristoylated CRMP2 peptide aptamer inhibits CaV2. 2 trafficking and reverses inflammatory and postoperative pain behaviors L François-Moutal, Y Wang, A Moutal, KE Cottier, OK Melemedjian, ... Pain 156 (7), 1247, 2015 | 77 | 2015 |
| CRISPR/Cas9 editing of Nf1 gene identifies CRMP2 as a therapeutic target in neurofibromatosis type 1-related pain that is reversed by (S)-Lacosamide A Moutal, X Yang, W Li, KB Gilbraith, S Luo, S Cai, L François-Moutal, ... Pain 158 (12), 2301, 2017 | 75 | 2017 |
| (S)-Lacosamide Binding to Collapsin Response Mediator Protein 2 (CRMP2) Regulates CaV2.2 Activity by Subverting Its Phosphorylation by Cdk5 A Moutal, L François-Moutal, S Perez-Miller, K Cottier, LA Chew, SK Yeon, ... Molecular neurobiology 53 (3), 1959-1976, 2016 | 60 | 2016 |
| Inhibition of the Ubc9 E2 SUMO conjugating enzyme–CRMP2 interaction decreases NaV1. 7 currents and reverses experimental neuropathic pain L François-Moutal, ET Dustrude, Y Wang, T Brustovetsky, A Dorame, W Ju, ... Pain 159 (10), 2115, 2018 | 53 | 2018 |
| Small Molecule Targeting TDP-43’s RNA Recognition Motifs Reduces Locomotor Defects in a Drosophila Model of Amyotrophic Lateral Sclerosis (ALS) L François-Moutal, R Felemban, DD Scott, MR Sayegh, VG Miranda, ... ACS chemical biology 14 (9), 2006-2013, 2019 | 48 | 2019 |
| Differential neuroprotective potential of CRMP2 peptide aptamers conjugated to cationic, hydrophobic, and amphipathic cell penetrating peptides A Moutal, L François-Moutal, JM Brittain, M Khanna, R Khanna Frontiers in cellular neuroscience 8, 471, 2015 | 43 | 2015 |
| The functionalized amino acid (S)-Lacosamide subverts CRMP2-mediated tubulin polymerization to prevent constitutive and activity-dependent increase in neurite outgrowth SM Wilson, A Moutal, OK Melemedjian, Y Wang, W Ju, L François-Moutal, ... Frontiers in cellular neuroscience 8, 196, 2014 | 43 | 2014 |
| Homology‐guided mutational analysis reveals the functional requirements for antinociceptive specificity of collapsin response mediator protein 2‐derived peptides A Moutal, W Li, Y Wang, W Ju, S Luo, S Cai, L François‐Moutal, ... British journal of pharmacology 175 (12), 2244-2260, 2018 | 41 | 2018 |
| Targeting the CaVα–CaVβ interaction yields an antagonist of the N-type CaV2. 2 channel with broad antinociceptive efficacy R Khanna, J Yu, X Yang, A Moutal, A Chefdeville, V Gokhale, Z Shuja, ... Pain 160 (7), 1644-1661, 2019 | 37 | 2019 |
| A single structurally conserved SUMOylation site in CRMP2 controls NaV1. 7 function ET Dustrude, S Perez-Miller, L François-Moutal, A Moutal, M Khanna, ... Channels 11 (4), 316-328, 2017 | 37 | 2017 |
| Caspase-8 binding to cardiolipin in giant unilamellar vesicles provides a functional docking platform for bid O Jalmar, L François-Moutal, AJ García-Sáez, M Perry, T Granjon, ... PloS one 8 (2), e55250, 2013 | 32 | 2013 |
| The natural flavonoid naringenin elicits analgesia through inhibition of NaV1. 8 voltage-gated sodium channels Y Zhou, S Cai, A Moutal, J Yu, K Gómez, CL Madura, Z Shan, NYN Pham, ... ACS chemical neuroscience 10 (12), 4834-4846, 2019 | 23 | 2019 |
| An allosteric modulator of RNA binding targeting the N-terminal domain of TDP-43 yields neuroprotective properties N Mollasalehi, L Francois-Moutal, DD Scott, JA Tello, H Williams, ... ACS Chemical Biology 15 (11), 2854-2859, 2020 | 21 | 2020 |
| Structural comparison of highly similar nucleoside-diphosphate kinases: molecular explanation of distinct membrane-binding behavior L Francois-Moutal, O Marcillat, T Granjon Biochimie 105, 110-118, 2014 | 17 | 2014 |
| Chemical shift perturbation mapping of the Ubc9-CRMP2 interface identifies a pocket in CRMP2 amenable for allosteric modulation of Nav1. 7 channels L François-Moutal, DD Scott, S Perez-Miller, V Gokhale, M Khanna, ... Channels 12 (1), 219-227, 2018 | 16 | 2018 |
| New insights into lipid-Nucleoside Diphosphate Kinase-D interaction mechanism: Protein structural changes and membrane reorganisation L Francois-Moutal, O Maniti, O Marcillat, T Granjon Biochimica et Biophysica Acta (BBA)-Biomembranes 1828 (2), 906-915, 2013 | 16 | 2013 |
| A chemical biology approach to model pontocerebellar hypoplasia type 1B (PCH1B) L François-Moutal, S Jahanbakhsh, ADL Nelson, D Ray, DD Scott, ... ACS chemical biology 13 (10), 3000-3010, 2018 | 11 | 2018 |
| In Silico Targeting of the Long Noncoding RNA MALAT1 L François-Moutal, VG Miranda, N Mollasalehi, V Gokhale, M Khanna ACS Medicinal Chemistry Letters, 2021 | 10 | 2021 |
| Direct targeting of TDP-43, from small molecules to biologics: the therapeutic landscape L Francois-Moutal, DD Scott, M Khanna RSC Chemical Biology, 2021 | 10 | 2021 |
