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Simon Lind
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Influence of local anesthetics upon human polymorphonuclear leukocyte function in vitro. Reduction of lysosomal enzyme release and superoxide anion production.
IM Goldstein, S Lind, S Hoffstein, G Weissmann
The Journal of experimental medicine 146 (2), 483-494, 1977
1511977
Neutrophil signaling that challenges dogmata of G protein-coupled receptor regulated functions
C Dahlgren, A Holdfeldt, S Lind, J Mårtensson, M Gabl, L Björkman, ...
ACS Pharmacology & Translational Science 3 (2), 203-220, 2020
332020
Functional selective ATP receptor signaling controlled by the free fatty acid receptor 2 through a novel allosteric modulation mechanism
S Lind, A Holdfeldt, J Mårtensson, M Sundqvist, L Björkman, H Forsman, ...
The FASEB Journal 33 (6), 6887-6903, 2019
262019
Functional and signaling characterization of the neutrophil FPR2 selective agonist Act-389949
S Lind, M Sundqvist, R Holmdahl, C Dahlgren, H Forsman, P Olofsson
Biochemical Pharmacology 166, 163-173, 2019
252019
Mitocryptides from human mitochondrial DNA–encoded proteins activate neutrophil formyl peptide receptors: receptor preference and signaling properties
M Gabl, M Sundqvist, A Holdfeldt, S Lind, J Mårtensson, K Christenson, ...
The Journal of Immunology 200 (9), 3269-3282, 2018
222018
Interdependent allosteric free fatty acid receptor 2 modulators synergistically induce functional selective activation and desensitization in neutrophils
S Lind, A Holdfeldt, J Mårtensson, M Sundqvist, TP Kenakin, L Björkman, ...
Biochimica et Biophysica Acta (BBA)-Molecular Cell Research 1867 (6), 118689, 2020
202020
Functional selective FPR1 signaling in favor of an activation of the neutrophil superoxide generating NOX2 complex
S Lind, C Dahlgren, R Holmdahl, P Olofsson, H Forsman
Journal of Leucocyte Biology 109 (6), 1105-1120, 2021
192021
G protein coupled pattern recognition receptors expressed in neutrophils: recognition, activation/modulation, signaling and receptor regulated functions
C Dahlgren, S Lind, J Mårtensson, L Björkman, Y Wu, M Sundqvist, ...
Immunological Reviews 314 (1), 69-92, 2023
142023
Identification of Residues Critical for FPR2 Activation by the Cryptic Peptide Mitocryptide-2 Originating from the Mitochondrial DNA–Encoded Cytochrome b
S Lind, M Gabl, A Holdfeldt, J Mårtensson, M Sundqvist, K Nishino, ...
The Journal of Immunology 202 (9), 2710-2719, 2019
132019
Multiple ligand recognition sites in free fatty acid receptor 2 (FFA2R) direct distinct neutrophil activation patterns
S Lind, A Holdfeldt, J Mårtensson, KL Granberg, H Forsman, C Dahlgren
Biochemical Pharmacology 193, 114762, 2021
82021
The PAR4-derived pepducin P4Pal10 lacks effect on neutrophil GPCRs that couple to gαq for signaling but distinctly modulates function of the gαi-coupled FPR2 and FFAR2
A Holdfeldt, S Lind, C Hesse, C Dahlgren, H Forsman
Biochemical Pharmacology 180, 114143, 2020
82020
Allosteric receptor modulation uncovers an FFA2R antagonist as a positive orthosteric modulator/agonist in disguise
S Lind, DO Hoffmann, H Forsman, C Dahlgren
Cellular signalling 90, 110208, 2022
72022
The ketone body acetoacetate activates human neutrophils through FFAR2
J Mårtensson, L Björkman, S Lind, MB Viklund, L Zhang, S Gutierrez, ...
Journal of Leukocyte Biology 113 (6), 577-587, 2023
52023
Weissmann 6. Influence of local anesthetics upon human polymorphonuclear leukocyte function in vib. 0. Reduction of lysosomal enzyme release and superoxide anion production
IM Goldstein, S Lind, S Hoffstein
Journal of Experimental Medicine 146, 483-494, 1977
51977
Phenol-soluble modulin α and β display divergent roles in mice with staphylococcal septic arthritis
Z Hu, PK Kopparapu, P Ebner, M Mohammad, S Lind, A Jarneborn, ...
Communications Biology 5 (1), 910, 2022
32022
The allosterically modulated FFAR2 is transactivated by signals generated by other neutrophil GPCRs
S Lind, KL Granberg, H Forsman, C Dahlgren
Plos one 18 (4), e0268363, 2023
22023
The Allosterically Modulated Free Fatty Acid Receptor 2 is Transactivated by an Increase in the Cytosolic Concentration of Calcium Ions
S Lind, Y Wu, M Sundqvist, H Forsman, C Dahlgren
bioRxiv, 2022.10. 15.512353, 2022
22022
Structural Determinants in the Staphylococcus aureus–Derived Phenol-Soluble Modulin α2 Peptide Required for Neutrophil Formyl Peptide Receptor Activation
M Viklund, J Fredriksson, A Holdfeldt, S Lind, H Franzyk, C Dahlgren, ...
The Journal of Immunology 208 (7), 1632-1641, 2022
22022
An increase in the cytosolic concentration of free calcium ions activates the neutrophil NADPH-oxidase provided that the free fatty acid receptor 2 has been allosterically …
S Lind, Y Wu, M Sundqvist, H Forsman, C Dahlgren
Cellular Signalling 107, 110687, 2023
12023
Signals Generated by Neutrophil Receptors for Danger Molecules Transactivate Allosterically Modulated FFA2R: Distinct response patterns are mediated by modulators recognized by …
S Lind, KL Granberg, H Forsman, C Dahlgren
BioRxiv, 2022.04. 29.489985, 2022
12022
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