| 5-FU promotes stemness of colorectal cancer via p53-mediated WNT/β-catenin pathway activation YH Cho, EJ Ro, JS Yoon, T Mizutani, DW Kang, JC Park, T Il Kim, ... Nature communications 11 (1), 5321, 2020 | 215 | 2020 |
| Ras stabilization through aberrant activation of Wnt/β-catenin signaling promotes intestinal tumorigenesis WJ Jeong, J Yoon, JC Park, SH Lee, SH Lee, S Kaduwal, H Kim, JB Yoon, ... Science signaling 5 (219), ra30-ra30, 2012 | 185 | 2012 |
| Revealing the activity of trimeric G-proteins in live cells with a versatile biosensor design M Maziarz, JC Park, A Leyme, A Marivin, A Garcia-Lopez, PP Patel, ... Cell 182 (3), 770-785. e16, 2020 | 60 | 2020 |
| A mutant KRAS‐induced factor REG4 promotes cancer stem cell properties via Wnt/β‐catenin signaling JH Hwang, J Yoon, YH Cho, PH Cha, JC Park, KY Choi International journal of cancer 146 (10), 2877-2890, 2020 | 35 | 2020 |
| WDR76 is a RAS binding protein that functions as a tumor suppressor via RAS degradation WJ Jeong, JC Park, WS Kim, EJ Ro, SH Jeon, SK Lee, YN Park, DS Min, ... Nature communications 10 (1), 295, 2019 | 34 | 2019 |
| KY1022, a small molecule destabilizing Ras via targeting the Wnt/β-catenin pathway, inhibits development of metastatic colorectal cancer YH Cho, PH Cha, S Kaduwal, JC Park, SK Lee, JS Yoon, W Shin, H Kim, ... Oncotarget 7 (49), 81727, 2016 | 33 | 2016 |
| Sur8/Shoc2 promotes cell motility and metastasis through activation of Ras-PI3K signaling S Kaduwal, WJ Jeong, JC Park, KH Lee, YM Lee, SH Jeon, YB Lim, ... Oncotarget 6 (32), 33091, 2015 | 32 | 2015 |
| Retinoic-acid-mediated HRas stabilization induces neuronal differentiation of neural stem cells during brain development JC Park, WJ Jeong, MY Kim, DS Min, KY Choi Journal of cell science 129 (15), 2997-3007, 2016 | 24 | 2016 |
| WDR76 degrades RAS and suppresses cancer stem cell activation in colorectal cancer EJ Ro, YH Cho, WJ Jeong, JC Park, DS Min, KY Choi Cell Communication and Signaling 17, 1-13, 2019 | 23 | 2019 |
| Destabilization of β-catenin and RAS by targeting the Wnt/β-catenin pathway as a potential treatment for triple-negative breast cancer WJ Ryu, JD Lee, JC Park, PH Cha, YH Cho, JY Kim, JH Sohn, S Paik, ... Experimental & Molecular Medicine 52 (5), 832-842, 2020 | 22 | 2020 |
| A biochemical and genetic discovery pipeline identifies PLCδ4b as a nonreceptor activator of heterotrimeric G-proteins M Maziarz, S Broselid, V DiGiacomo, JC Park, A Luebbers, ... Journal of Biological Chemistry 293 (44), 16964-16983, 2018 | 20 | 2018 |
| K-Ras stabilization by estrogen via PKCδ is involved in endometrial tumorigenesis KH Koo, WJ Jeong, YH Cho, JC Park, KY Choi Oncotarget 6 (25), 21328, 2015 | 20 | 2015 |
| WDR76 mediates obesity and hepatic steatosis via HRas destabilization JC Park, WJ Jeong, SH Seo, KY Choi Scientific reports 9 (1), 19676, 2019 | 11 | 2019 |
| Identification of Ras-degrading small molecules that inhibit the transformation of colorectal cancer cells independent of β-catenin signaling W Shin, SK Lee, JH Hwang, JC Park, YH Cho, EJ Ro, Y Song, HR Seo, ... Experimental & molecular medicine 50 (6), 1-10, 2018 | 11 | 2018 |
| Fine-tuning GPCR-mediated neuromodulation by biasing signaling through different G protein subunits JC Park, A Luebbers, M Dao, A Semeano, AM Nguyen, ... Molecular cell 83 (14), 2540-2558. e12, 2023 | 8 | 2023 |
| Sur8 mediates tumorigenesis and metastasis in colorectal cancer YM Lee, S Kaduwal, KH Lee, JC Park, WJ Jeong, KY Choi Experimental & molecular medicine 48 (7), e249-e249, 2016 | 6 | 2016 |
| Small-molecule targeting of GPCR-independent noncanonical G-protein signaling in cancer J Zhao, V DiGiacomo, M Ferreras-Gutierrez, S Dastjerdi, ... Proceedings of the National Academy of Sciences 120 (18), e2213140120, 2023 | 4 | 2023 |
| Direct interrogation of context-dependent GPCR activity with a universal biosensor platform R Janicot, M Maziarz, JC Park, J Zhao, A Luebbers, E Green, CE Philibert, ... Cell, 2024 | 2 | 2024 |
| Detecting GPCR Signals With Optical Biosensors of Gα‐GTP in Cell Lines and Primary Cell Cultures R Janicot, JC Park, M Garcia‐Marcos Current protocols 3 (6), e796, 2023 | 2 | 2023 |
| Development of Transgenic Mouse Platform for the Detection of Endogenous G protein Activity R Janicot, M Maziarz, JC Park, M Garcia-Marcos Journal of Pharmacology and Experimental Therapeutics 385 (S3), 2023 | | 2023 |
