| The Structure of a Human p110 {alpha}/p85 {alpha} Complex Elucidates the Effects of Oncogenic PI3K {alpha} Mutations CH Huang, D Mandelker, O Schmidt-Kittler, Y Samuels, VE Velculescu, ... Science 318 (5857), 1744, 2007 | 642 | 2007 |
| Eukaryotic chemotaxis: a network of signaling pathways controls motility, directional sensing, and polarity KF Swaney*, CH Huang*, PN Devreotes Annual review of biophysics 39, 265-289, 2010 | 592 | 2010 |
| A frequent kinase domain mutation that changes the interaction between PI3Kα and the membrane D Mandelker, SB Gabelli, O Schmidt-Kittler, J Zhu, I Cheong, CH Huang, ... Proceedings of the National Academy of Sciences 106 (40), 16996-17001, 2009 | 310 | 2009 |
| Cells navigate with a local-excitation, global-inhibition-biased excitable network Y Xiong, CH Huang, PA Iglesias, PN Devreotes Proceedings of the National Academy of Sciences 107 (40), 17079-17086, 2010 | 299 | 2010 |
| An excitable signal integrator couples to an idling cytoskeletal oscillator to drive cell migration CH Huang, M Tang, C Shi, PA Iglesias, PN Devreotes Nature cell biology 15 (11), 1307-1316, 2013 | 219 | 2013 |
| Interaction of motility, directional sensing, and polarity modules recreates the behaviors of chemotaxing cells C Shi, CH Huang, PN Devreotes, PA Iglesias PLoS computational biology 9 (7), e1003122, 2013 | 120 | 2013 |
| Cancer immunotherapy using a DNA vaccine encoding a single-chain trimer of MHC class I linked to an HPV-16 E6 immunodominant CTL epitope CH Huang, S Peng, L He, YC Tsai, DAK Boyd, TH Hansen, TC Wu, ... Gene therapy 12 (15), 1180-1186, 2005 | 119 | 2005 |
| Structural comparisons of class I phosphoinositide 3-kinases LM Amzel*, CH Huang*, D Mandelker, C Lengauer, SB Gabelli, ... Nature Reviews Cancer 8 (9), 665-669, 2008 | 115 | 2008 |
| Insights into the oncogenic effects of/PIK3CA/mutations from the structure of p110α/p85α CH Huang, D Mandelker, SB Gabelli, LM Amzel Cell Cycle 7 (9), 1151-1156, 2008 | 103 | 2008 |
| Evolutionarily conserved coupling of adaptive and excitable networks mediates eukaryotic chemotaxis M Tang, M Wang, C Shi, PA Iglesias, PN Devreotes, CH Huang Nature communications 5, 5175, 2014 | 93 | 2014 |
| NKCC1 Regulates Migration Ability of Glioblastoma Cells by Modulation of Actin Dynamics and Interacting with Cofilin P Schiapparelli, H Guerrero-Cazares, R Magaña-Maldonado, SM Hamilla, ... EBioMedicine 21, 94-103, 2017 | 72 | 2017 |
| An Excitable Ras/PI3K/ERK Signaling Network Controls Migration and Oncogenic Transformation in Epithelial Cells H Zhan, S Bhattacharya, H Cai, PA Iglesias, CH Huang*, PN Devreotes* Developmental Cell, 2020 | 58 | 2020 |
| Integrating chemical and mechanical signals through dynamic coupling between cellular protrusions and pulsed ERK activation JM Yang, S Bhattacharya, H West-Foyle, CF Hung, TC Wu, PA Iglesias, ... Nature Communications 9 (1), 4673, 2018 | 52 | 2018 |
| Development of DNA Vaccine Targeting E6 and E7 Proteins of Human Papillomavirus 16 (HPV16) and HPV18 for Immunotherapy in Combination with Recombinant Vaccinia Boost and PD-1 … S Peng, L Ferrall, S Gaillard, C Wang, WY Chi, CH Huang, RBS Roden, ... Mbio 12 (1), 2021 | 47 | 2021 |
| Binding of nitrogen‐containing bisphosphonates (N‐BPs) to the Trypanosoma cruzi farnesyl diphosphate synthase homodimer CH Huang, SB Gabelli, E Oldfield, LM Amzel Proteins: Structure, Function, and Bioinformatics 78 (4), 888-899, 2010 | 46 | 2010 |
| Gβ regulates coupling between actin oscillators for cell polarity and directional migration O Hoeller, JE Toettcher, H Cai, Y Sun, CH Huang, M Freyre, M Zhao, ... PLoS biology 14 (2), e1002381, 2016 | 42 | 2016 |
| Analysis of chemotaxis in Dictyostelium H Cai, CH Huang, PN Devreotes, M Iijima Integrin and Cell Adhesion Molecules: Methods and Protocols, 451-468, 2012 | 39 | 2012 |
| Deciphering cell signaling networks with massively multiplexed biosensor barcoding JM Yang, WY Chi, J Liang, S Takayanagi, PA Iglesias, CH Huang Cell, 2021 | 34 | 2021 |
| Structural effects of oncogenic PI3Kα mutations SB Gabelli, CH Huang, D Mandelker, O Schmidt-Kittler, B Vogelstein, ... Phosphoinositide 3-kinase in Health and Disease, 43-53, 2010 | 29 | 2010 |
| Inhibition of ovarian tumor cell invasiveness by targeting SYK in the tyrosine kinase signaling pathway Y Yu, YS Rahmanto, MH Lee, PH Wu, JM Phillip, CH Huang, MI Vitolo, ... Oncogene, 1, 2018 | 27 | 2018 |
Peter Devreotes, Professor of Cell Biol...Johns Hopkins University School of MedicineVerified email at jhmi.edu
