| How to improve R&D productivity: the pharmaceutical industry's grand challenge SM Paul, DS Mytelka, CT Dunwiddie, CC Persinger, BH Munos, ... Nature reviews Drug discovery 9 (3), 203-214, 2010 | 4306 | 2010 |
| Steroid hormone metabolites are barbiturate-like modulators of the GABA receptor MD Majewska, NL Harrison, RD Schwartz, JL Barker, SM Paul Science 232 (4753), 1004-1007, 1986 | 2678 | 1986 |
| Neuroactive steroids SM Paul, RH Purdy The FASEB Journal 6 (6), 2311-2322, 1992 | 1968 | 1992 |
| Peripheral anti-Aβ antibody alters CNS and plasma Aβ clearance and decreases brain Aβ burden in a mouse model of Alzheimer's disease RB DeMattos, KR Bales, DJ Cummins, JC Dodart, SM Paul, DM Holtzman Proceedings of the National Academy of Sciences 98 (15), 8850-8855, 2001 | 1742 | 2001 |
| Synaptic activity regulates interstitial fluid amyloid-β levels in vivo JR Cirrito, KA Yamada, MB Finn, RS Sloviter, KR Bales, PC May, ... Neuron 48 (6), 913-922, 2005 | 1409 | 2005 |
| Human apoE isoforms differentially regulate brain amyloid-β peptide clearance JM Castellano, J Kim, FR Stewart, H Jiang, RB DeMattos, BW Patterson, ... Science translational medicine 3 (89), 89ra57-89ra57, 2011 | 1384 | 2011 |
| Nicotinic binding in rat brain: autoradiographic comparison of [3H] acetylcholine,[3H] nicotine, and [125I]-alpha-bungarotoxin PB Clarke, RD Schwartz, SM Paul, CB Pert, AGU Pert Journal of Neuroscience 5 (5), 1307-1315, 1985 | 1325 | 1985 |
| Immunization reverses memory deficits without reducing brain Aβ burden in Alzheimer's disease model JC Dodart, KR Bales, KS Gannon, SJ Greene, RB DeMattos, C Mathis, ... Nature neuroscience 5 (5), 452-457, 2002 | 1236 | 2002 |
| Apolipoprotein E isoform-dependent amyloid deposition and neuritic degeneration in a mouse model of Alzheimer's disease DM Holtzman, KR Bales, T Tenkova, AM Fagan, M Parsadanian, ... Proceedings of the National Academy of Sciences 97 (6), 2892-2897, 2000 | 1135 | 2000 |
| Stress-induced elevations of gamma-aminobutyric acid type A receptor-active steroids in the rat brain. RH Purdy, AL Morrow, PH Moore Jr, SM Paul Proceedings of the National Academy of Sciences 88 (10), 4553-4557, 1991 | 1128 | 1991 |
| Lack of apolipoprotein E dramatically reduces amyloid β-peptide deposition KR Bales, T Verina, RC Dodel, Y Du, L Altstiel, M Bender, P Hyslop, ... Nature genetics 17 (3), 263-264, 1997 | 1079 | 1997 |
| Receptors for the age of anxiety: pharmacology of the benzodiazepines JF Tallman, SM Paul, P Skolnick, DW Gallager Science 207 (4428), 274-281, 1980 | 1062 | 1980 |
| ApoE4 markedly exacerbates tau-mediated neurodegeneration in a mouse model of tauopathy Y Shi, K Yamada, SA Liddelow, ST Smith, L Zhao, W Luo, RM Tsai, ... Nature 549 (7673), 523-527, 2017 | 983 | 2017 |
| Responses to corticotropin-releasing hormone in the hypercortisolism of depression and Cushing's disease PW Gold, DL Loriaux, A Roy, MA Kling, JR Calabrese, CH Kellner, ... New England Journal of Medicine 314 (21), 1329-1335, 1986 | 962 | 1986 |
| Minocycline prevents nigrostriatal dopaminergic neurodegeneration in the MPTP model of Parkinson's disease Y Du, Z Ma, S Lin, RC Dodel, F Gao, KR Bales, LC Triarhou, E Chernet, ... Proceedings of the National Academy of Sciences 98 (25), 14669-14674, 2001 | 957 | 2001 |
| P-glycoprotein deficiency at the blood-brain barrier increases amyloid-β deposition in an Alzheimer disease mouse model JR Cirrito, R Deane, AM Fagan, ML Spinner, M Parsadanian, MB Finn, ... The Journal of clinical investigation 115 (11), 3285-3290, 2005 | 763 | 2005 |
| Effects of xanomeline, a selective muscarinic receptor agonist, on cognitive function and behavioral symptoms in Alzheimer disease NC Bodick, WW Offen, AI Levey, NR Cutler, SG Gauthier, A Satlin, ... Archives of neurology 54 (4), 465-473, 1997 | 763 | 1997 |
| Neuronal sorting protein-related receptor sorLA/LR11 regulates processing of the amyloid precursor protein OM Andersen, J Reiche, V Schmidt, M Gotthardt, R Spoelgen, J Behlke, ... Proceedings of the National Academy of Sciences 102 (38), 13461-13466, 2005 | 757 | 2005 |
| Brain to plasma amyloid-β efflux: a measure of brain amyloid burden in a mouse model of Alzheimer's disease RB DeMattos, KR Bales, DJ Cummins, SM Paul, DM Holtzman science 295 (5563), 2264-2267, 2002 | 744 | 2002 |
| TREM2 haplodeficiency in mice and humans impairs the microglia barrier function leading to decreased amyloid compaction and severe axonal dystrophy P Yuan, C Condello, CD Keene, Y Wang, TD Bird, SM Paul, W Luo, ... Neuron 90 (4), 724-739, 2016 | 724 | 2016 |
Kelly R. BalesVoyager TherapeuticsVerified email at vygr.com
