Protein cargo delivery properties of cell-penetrating peptides. A comparative study P Säälik, A Elmquist, M Hansen, K Padari, K Saar, K Viht, Ü Langel, ... Bioconjugate chemistry 15 (6), 1246-1253, 2004 | 276 | 2004 |
Conjugation of Adenosine and Hexa-(d-arginine) Leads to a Nanomolar Bisubstrate-Analog Inhibitor of Basophilic Protein Kinases E Enkvist, D Lavogina, G Raidaru, A Vaasa, I Viil, M Lust, K Viht, A Uri Journal of medicinal chemistry 49 (24), 7150-7159, 2006 | 81 | 2006 |
High-affinity bisubstrate probe for fluorescence anisotropy binding/displacement assays with protein kinases PKA and ROCK A Vaasa, I Viil, E Enkvist, K Viht, G Raidaru, D Lavogina, A Uri Analytical biochemistry 385 (1), 85-93, 2009 | 77 | 2009 |
Surface-plasmon-resonance-based biosensor with immobilized bisubstrate analog inhibitor for the determination of affinities of ATP-and protein-competitive ligands of cAMP … K Viht, S Schweinsberg, M Lust, A Vaasa, G Raidaru, D Lavogina, A Uri, ... Analytical biochemistry 362 (2), 268-277, 2007 | 49 | 2007 |
A subnanomolar fluorescent probe for protein kinase CK2 interaction studies E Enkvist, K Viht, N Bischoff, J Vahter, S Saaver, G Raidaru, OG Issinger, ... Organic & biomolecular chemistry 10 (43), 8645-8653, 2012 | 44 | 2012 |
Fluorometric TLC assay for evaluation of protein kinase inhibitors K Viht, A Vaasa, G Raidaru, E Enkvist, A Uri Analytical biochemistry 340 (1), 165-170, 2005 | 34 | 2005 |
Acetoxymethyl Ester of Tetrabromobenzimidazole–Peptoid Conjugate for Inhibition of Protein Kinase CK2 in Living Cells K Viht, S Saaver, J Vahter, E Enkvist, D Lavogina, H Sinijärv, G Raidaru, ... Bioconjugate chemistry 26 (12), 2324-2335, 2015 | 29 | 2015 |
Benzoselenadiazole-based responsive long-lifetime photoluminescent probes for protein kinases R Ekambaram, E Enkvist, G babu Manoharan, M Ugandi, M Kasari, K Viht, ... Chemical communications 50 (31), 4096-4098, 2014 | 25 | 2014 |
Bisubstrate fluorescent probes and biosensors in binding assays for HTS of protein kinase inhibitors A Uri, M Lust, A Vaasa, D Lavogina, K Viht, E Enkvist Biochimica et Biophysica Acta (BBA)-Proteins and Proteomics 1804 (3), 541-546, 2010 | 25 | 2010 |
Responsive microsecond-lifetime photoluminescent probes for analysis of protein kinases and their inhibitors M Kasari, K Ligi, JAG Williams, A Vaasa, E Enkvist, K Viht, LO Pålsson, ... Biochimica et Biophysica Acta (BBA)-Proteins and Proteomics 1834 (7), 1330-1335, 2013 | 24 | 2013 |
Liquid-phase synthesis of a pegylated adenosine–oligoarginine conjugate, cell-permeable inhibitor of cAMP-dependent protein kinase K Viht, K Padari, G Raidaru, J Subbi, I Tammiste, M Pooga, A Uri Bioorganic & medicinal chemistry letters 13 (18), 3035-3039, 2003 | 24 | 2003 |
A selective biligand inhibitor of CK2 increases caspase‐3 activity in cancer cells and inhibits platelet aggregation H Rahnel, K Viht, D Lavogina, O Mazina, T Haljasorg, E Enkvist, A Uri ChemMedChem 12 (20), 1723-1736, 2017 | 23 | 2017 |
Unexpected CK2β-antagonistic functionality of bisubstrate inhibitors targeting protein kinase CK2 M Pietsch, K Viht, A Schnitzler, R Ekambaram, M Steinkrueger, E Enkvist, ... Bioorganic Chemistry 96, 103608, 2020 | 17 | 2020 |
Long Residence Times Revealed by Aurora A Kinase‐Targeting Fluorescent Probes Derived from Inhibitors MLN8237 and VX‐689 D Lavogina, E Enkvist, K Viht, A Uri ChemBioChem 15 (3), 443-450, 2014 | 17 | 2014 |
Thiazole-and selenazole-comprising high-affinity inhibitors possess bright microsecond-scale photoluminescence in complex with protein kinase CK2 J Vahter, K Viht, A Uri, G babu Manoharan, E Enkvist Bioorganic & medicinal chemistry 26 (18), 5062-5068, 2018 | 16 | 2018 |
Efficient photocaging of a tight-binding bisubstrate inhibitor of cAMP-dependent protein kinase T Sõrmus, D Lavogina, E Enkvist, A Uri, K Viht Chemical communications 55 (74), 11147-11150, 2019 | 15 | 2019 |
Amyloid precursor protein carboxy-terminal fragments modulate G-proteins and adenylate cyclase activity in Alzheimer’s disease brain R Mahlapuu, K Viht, L Balaspiri, N Bogdanovic, K Saar, U Soomets, ... Molecular brain research 117 (1), 73-82, 2003 | 15 | 2003 |
Oligo-aspartic acid conjugates with benzo [c][2, 6] naphthyridine-8-carboxylic acid scaffold as picomolar inhibitors of CK2 J Vahter, K Viht, A Uri, E Enkvist Bioorganic & Medicinal Chemistry 25 (7), 2277-2284, 2017 | 14 | 2017 |
Binding assay for characterization of protein kinase inhibitors possessing sub-picomolar to sub-millimolar affinity H Sinijarv, S Wu, T Ivan, T Laasfeld, K Viht, A Uri Analytical Biochemistry 531, 67-77, 2017 | 13 | 2017 |
Slowly on, Slowly off: Bisubstrate‐Analogue Conjugates of 5‐Iodotubercidin and Histone H3 Peptide Targeting Protein Kinase Haspin K Kestav, K Viht, A Konovalov, E Enkvist, A Uri, D Lavogina Chembiochem 18 (8), 790-798, 2017 | 13 | 2017 |