| Discovery of Imidazo[1,2-a]pyridine Ethers and Squaramides as Selective and Potent Inhibitors of Mycobacterial Adenosine Triphosphate (ATP) Synthesis SJ Tantry, SD Markad, V Shinde, J Bhat, G Balakrishnan, AK Gupta, ... Journal of medicinal chemistry 60 (4), 1379-1399, 2017 | 111 | 2017 |
| Reducing attrition in drug development: smart loading preclinical safety assessment RA Roberts, SL Kavanagh, HR Mellor, CE Pollard, S Robinson, SJ Platz Drug discovery today 19 (3), 341-347, 2014 | 103 | 2014 |
| 4-aminoquinolone piperidine amides: noncovalent inhibitors of DprE1 with long residence time and potent antimycobacterial activity M Naik, V Humnabadkar, SJ Tantry, M Panda, A Narayan, S Guptha, ... Journal of medicinal chemistry 57 (12), 5419-5434, 2014 | 95 | 2014 |
| AWZ1066S, a highly specific anti-Wolbachia drug candidate for a short-course treatment of filariasis WD Hong, F Benayoud, GL Nixon, L Ford, KL Johnston, RH Clare, ... Proceedings of the National Academy of Sciences 116 (4), 1414-1419, 2019 | 68 | 2019 |
| Triaminopyrimidine is a fast-killing and long-acting antimalarial clinical candidate S Hameed P, S Solapure, V Patil, PP Henrich, PA Magistrado, S Bharath, ... Nature Communications 6 (1), 6715, 2015 | 68 | 2015 |
| Discovery of AZD9833, a potent and orally bioavailable selective estrogen receptor degrader and antagonist JS Scott, TA Moss, A Balazs, B Barlaam, J Breed, RJ Carbajo, ... Journal of Medicinal Chemistry 63 (23), 14530-14559, 2020 | 66 | 2020 |
| N-Aryl-2-aminobenzimidazoles: Novel, Efficacious, Antimalarial Lead Compounds S Ramachandran, S Hameed P, A Srivastava, G Shanbhag, S Morayya, ... Journal of Medicinal Chemistry 57 (15), 6642-6652, 2014 | 42 | 2014 |
| Aminoazabenzimidazoles, a novel class of orally active antimalarial agents S Hameed P, M Chinnapattu, G Shanbag, P Manjrekar, K Koushik, ... Journal of Medicinal Chemistry 57 (13), 5702-5713, 2014 | 33 | 2014 |
| Scaffold morphing leading to evolution of 2, 4-diaminoquinolines and aminopyrazolopyrimidines as inhibitors of the ATP synthesis pathway SJ Tantry, V Shinde, G Balakrishnan, SD Markad, AK Gupta, J Bhat, ... MedChemComm 7 (5), 1022-1032, 2016 | 28 | 2016 |
| Human stem cell osteoblastogenesis mediated by novel glycogen synthase kinase 3 inhibitors induces bone formation and a unique bone turnover biomarker profile in rats PS Gilmour, PJ O'Shea, M Fagura, JE Pilling, H Sanganee, H Wada, ... Toxicology and applied pharmacology 272 (2), 399-407, 2013 | 22 | 2013 |
| Circumventing seizure activity in a series of G protein coupled receptor 119 (GPR119) agonists JS Scott, SS Bowker, KJ Brocklehurst, HS Brown, DS Clarke, A Easter, ... Journal of Medicinal Chemistry 57 (21), 8984-8998, 2014 | 21 | 2014 |
| Discovery of clinical candidate AZD0095, a selective inhibitor of monocarboxylate transporter 4 (MCT4) for oncology FW Goldberg, JG Kettle, GM Lamont, D Buttar, AKT Ting, TM McGuire, ... Journal of Medicinal Chemistry 66 (1), 384-397, 2022 | 14 | 2022 |
| Development of Pyrazolopyrimidine Anti-Wolbachia Agents for the Treatment of Filariasis P McGillan, NG Berry, GL Nixon, SC Leung, PJH Webborn, MC Wenlock, ... ACS Medicinal Chemistry Letters 12 (9), 1421-1426, 2021 | 8 | 2021 |
| Discovery of a Potent and Orally Bioavailable Zwitterionic Series of Selective Estrogen Receptor Degrader-Antagonists JS Scott, D Stead, B Barlaam, J Breed, RJ Carbajo, E Chiarparin, ... Journal of Medicinal Chemistry 66 (4), 2918-2945, 2023 | 7 | 2023 |
| Enhanced hepatic respiratory capacity and altered lipid metabolism support metabolic homeostasis during short-term hypoxic stress KA O’Brien, BD McNally, AP Sowton, A Murgia, J Armitage, LW Thomas, ... BMC biology 19, 1-20, 2021 | 3 | 2021 |
| Reducing attrition in drug development: Smart loading pre-clinical safety assessment S Kavanagh, H Mellor, C Pollard, S Robinson, S Platz, R Roberts Toxicology Letters, S167, 2014 | 2 | 2014 |
| Discovery, Optimization, and Biological Evaluation of Arylpyridones as Cbl-b Inhibitors AM Mfuh, JA Boerth, G Bommakanti, C Chan, AJ Chinn, E Code, PJ Fricke, ... Journal of Medicinal Chemistry 67 (2), 1500-1512, 2024 | 1 | 2024 |
| Discovery of a Novel Benzodiazepine Series of Cbl-b Inhibitors for the Enhancement of Antitumor Immunity JA Boerth, AJ Chinn, M Schimpl, G Bommakanti, C Chan, EL Code, ... ACS Medicinal Chemistry Letters 14 (12), 1848-1856, 2023 | 1 | 2023 |
| Acetylcholinesterase: Is there a recommended level of off target activity that can be tolerated and predicted safe? LR Ribeiro, M Morton, L Wright, S Kavanagh, M Rolf, D Armstrong, ... Journal of Pharmacological and Toxicological Methods 70 (3), 327, 2014 | 1 | 2014 |
| Data supporting" Enhanced hepatic respiratory capacity and altered lipid metabolism supports metabolic homeostasis during short-term hypoxic stress" K O'Brien, B McNally, A Sowton, A Murgia, J Armitage, L Thomas, ... | | 2021 |
