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Guilherme Gil Moreira
Guilherme Gil Moreira
BioISI - Faculdade de Ciências, Universidade de Lisboa
Email confirmado em fc.ul.pt - Página inicial
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Zinc binding to tau influences aggregation kinetics and oligomer distribution
GG Moreira, JS Cristóvão, VM Torres, AP Carapeto, MS Rodrigues, ...
International Journal of Molecular Sciences 20 (23), 5979, 2019
322019
Dynamic interactions and Ca2+-binding modulate the holdase-type chaperone activity of S100B preventing tau aggregation and seeding
GG Moreira, FX Cantrelle, A Quezada, FS Carvalho, JS Cristóvão, ...
Nature communications 12 (1), 6292, 2021
182021
Cu 2+-binding to S100B triggers polymerization of disulfide cross-linked tetramers with enhanced chaperone activity against amyloid-β aggregation
JS Cristóvão, GG Moreira, FEP Rodrigues, AP Carapeto, MS Rodrigues, ...
Chemical Communications 57 (3), 379-382, 2021
82021
Tau liquid–liquid phase separation is modulated by the Ca2+‐switched chaperone activity of the S100B protein
GG Moreira, CM Gomes
Journal of Neurochemistry 166 (1), 76-86, 2023
72023
Tetramerization of the S100B chaperone spawns a Ca2+ independent regulatory surface that enhances anti-aggregation activity and client specificity
AJ Figueira, GG Moreira, J Saavedra, I Cardoso, CM Gomes
Journal of Molecular Biology 434 (19), 167791, 2022
52022
A novel extracellular chaperone prevents tau aggregation and proteotoxicity
G Moreira, F Cantrelle, A Quezada, FS Carvalho, J Cristovao, U Sengupta, ...
FEBS OPEN BIO 12, 123-124, 2022
2022
Tau pathological aggregation and liquid-liquid phase separation are precluded by the S100B chaperone
GG Moreira, CM Gomes
FEBS OPEN BIO 12, 274-275, 2022
2022
Metals and amyloid gain-of-toxic mechanisms in neurodegenerative diseases
JS Cristóvão, GG Moreira, AM Grabrucker, CM Gomes
Protein Homeostasis Diseases, 181-195, 2020
2020
Biochemistry of Tau Aggregation and Interactions in Alzheimer's Disease
GGSV Moreira
PQDT-Global, 2018
2018
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Artigos 1–9