| Role of P-glycoprotein on the CNS disposition of amprenavir (141W94), an HIV protease inhibitor JW Polli, JL Jarrett, SD Studenberg, JE Humphreys, SW Dennis, ... Pharmaceutical research 16, 1206-1212, 1999 | 277 | 1999 |
| Correlation of biliary excretion in sandwich-cultured rat hepatocytes and in vivo in rats X Liu, JP Chism, EL LeCluyse, KR Brouwer, KLR Brouwer Drug Metabolism and Disposition 27 (6), 637-644, 1999 | 273 | 1999 |
| Biliary excretion in primary rat hepatocytes cultured in a collagen-sandwich configuration X Liu, EL LeCluyse, KR Brouwer, LSL Gan, JJ Lemasters, B Stieger, ... American Journal of Physiology-Gastrointestinal and Liver Physiology 277 (1 …, 1999 | 268 | 1999 |
| Effects of a potent and specific P-glycoprotein inhibitor on the blood-brain barrier distribution and antinociceptive effect of morphine in the rat SP Letrent, GM Pollack, KR Brouwer, KLR Brouwer Drug metabolism and disposition 27 (7), 827-834, 1999 | 209 | 1999 |
| Induction of P-glycoprotein and cytochrome P450 3A by HIV protease inhibitors L Huang, SA Wring, JL Woolley, KR Brouwer, C Serabjit-Singh, JW Polli Drug metabolism and disposition 29 (5), 754-760, 2001 | 171 | 2001 |
| Increased oral bioavailability of paclitaxel by GF120918 in mice through selective modulation of P-glycoprotein HA Bardelmeijer, JH Beijnen, KR Brouwer, H Rosing, WJ Nooijen, ... Clinical cancer research 6 (11), 4416-4421, 2000 | 167 | 2000 |
| Use of Ca2+ modulation to evaluate biliary excretion in sandwich-cultured rat hepatocytes X Liu, EL LeCluyse, KR Brouwer, RM Lightfoot, JI Lee, KLR Brouwer Journal of Pharmacology and Experimental Therapeutics 289 (3), 1592-1599, 1999 | 158 | 1999 |
| P-glycoprotein-mediated transport of morphine in brain capillary endothelial cells SP Letrent, JW Polli, JE Humphreys, GM Pollack, KR Brouwer, ... Biochemical pharmacology 58 (6), 951-957, 1999 | 124 | 1999 |
| Effect of GF120918, a potent P-glycoprotein inhibitor, on morphine pharmacokinetics and pharmacodynamics in the rat SP Letrent, GM Pollack, KR Brouwer, KLR Brouwer Pharmaceutical research 15, 599-605, 1998 | 111 | 1998 |
| Partial maintenance of taurocholate uptake by adult rat hepatocytes cultured in a collagen sandwich configuration X Liu, KLR Brouwer, LSL Gan, KR Brouwer, B Stieger, PJ Meier, ... Pharmaceutical research 15, 1533-1539, 1998 | 102 | 1998 |
| An in vitro assay to assess transporter-based cholestatic hepatotoxicity using sandwich-cultured rat hepatocytes JH Ansede, WR Smith, CH Perry, RLS Claire, KR Brouwer Drug Metabolism and Disposition 38 (2), 276-280, 2010 | 89 | 2010 |
| Can bile salt export pump inhibition testing in drug discovery and development reduce liver injury risk? An international transporter consortium perspective JG Kenna, KS Taskar, C Battista, DL Bourdet, KLR Brouwer, KR Brouwer, ... Clinical Pharmacology & Therapeutics 104 (5), 916-932, 2018 | 87 | 2018 |
| Evaluation of the endothelin receptor antagonists ambrisentan, darusentan, bosentan, and sitaxsentan as substrates and inhibitors of hepatobiliary transporters in sandwich … JC Hartman, K Brouwer, A Mandagere, L Melvin, R Gorczynski Canadian journal of physiology and pharmacology 88 (6), 682-691, 2010 | 87 | 2010 |
| GF120918, a P-glycoprotein modulator, increases the concentration of unbound amprenavir in the central nervous system in rats JE Edwards, KR Brouwer, PJ McNamara Antimicrobial agents and chemotherapy 46 (7), 2284-2286, 2002 | 80 | 2002 |
| Evaluation of the endothelin receptor antagonists ambrisentan, bosentan, macitentan, and sitaxsentan as hepatobiliary transporter inhibitors and substrates in sandwich-cultured … EI Lepist, H Gillies, W Smith, J Hao, C Hubert, RL St. Claire III, ... PloS one 9 (1), e87548, 2014 | 72 | 2014 |
| Effect of multidrug resistance modulators on the hepatobiliary disposition of doxorubicin in the isolated perfused rat liver CL Booth, KR Brouwer, KLR Brouwer Cancer research 58 (16), 3641-3648, 1998 | 72 | 1998 |
| Obeticholic acid, a selective farnesoid X receptor agonist, regulates bile acid homeostasis in sandwich‐cultured human hepatocytes Y Zhang, JP Jackson, RL St. Claire III, K Freeman, KR Brouwer, ... Pharmacology Research & Perspectives 5 (4), e00329, 2017 | 49 | 2017 |
| Inhibition of human hepatic bile acid transporters by tolvaptan and metabolites: contributing factors to drug-induced liver injury? JR Slizgi, Y Lu, KR Brouwer, RL St. Claire, KM Freeman, M Pan, WJ Brock, ... Toxicological Sciences 149 (1), 237-250, 2016 | 43 | 2016 |
| Farnesoid X receptor agonists obeticholic acid and chenodeoxycholic acid increase bile acid efflux in sandwich-cultured human hepatocytes: functional evidence and mechanisms C Guo, C LaCerte, JE Edwards, KR Brouwer, KLR Brouwer Journal of Pharmacology and Experimental Therapeutics 365 (2), 413-421, 2018 | 41 | 2018 |
| Comparative potency of obeticholic acid and natural bile acids on FXR in hepatic and intestinal in vitro cell models Y Zhang, C LaCerte, S Kansra, JP Jackson, KR Brouwer, JE Edwards Pharmacology Research & Perspectives 5 (6), e00368, 2017 | 37 | 2017 |
