| BRIEF REVIEW PROTEINS OF THE BCL-2 FAMILY IN APOPTOSIS SIGNALLING: FROM MECHANISTIC INSIGHTS TO THERAPEUTIC OPPORTUNITIES. SL Chan, VC Yu Clinical & Experimental Pharmacology & Physiology 31 (3), 2004 | 249 | 2004 |
| Identification of chelerythrine as an inhibitor of BclXL function SL Chan, MC Lee, KO Tan, LK Yang, ASY Lee, H Flotow, NY Fu, ... Journal of Biological Chemistry 278 (23), 20453-20456, 2003 | 230 | 2003 |
| CD44v8-10 is a cancer-specific marker for gastric cancer stem cells WM Lau, E Teng, HS Chong, KAP Lopez, AYL Tay, M Salto-Tellez, ... Cancer research 74 (9), 2630-2641, 2014 | 220 | 2014 |
| MAP-1, a novel proapoptotic protein containing a BH3-like motif that associates with Bax through its Bcl-2 homology domains KO Tan, KML Tan, SL Chan, KSY Yee, M Bévort, KC Ang, CY Victor Journal of Biological Chemistry 276 (4), 2802-2807, 2001 | 169 | 2001 |
| MAP-1 is a mitochondrial effector of Bax KO Tan, NY Fu, SK Sukumaran, SL Chan, JH Kang, KL Poon, BS Chen, ... Proceedings of the National Academy of Sciences 102 (41), 14623-14628, 2005 | 146 | 2005 |
| Sequential expression of putative stem cell markers in gastric carcinogenesis T Wang, CW Ong, J Shi, S Srivastava, B Yan, CL Cheng, WP Yong, ... British journal of cancer 105 (5), 658-665, 2011 | 138 | 2011 |
| Runx3 protects gastric epithelial cells against epithelial-mesenchymal transition-induced cellular plasticity and tumorigenicity DCC Voon, H Wang, JKW Koo, TAP Nguyen, YT Hor, YS Chu, K Ito, ... Stem cells 30 (10), 2088-2099, 2012 | 109 | 2012 |
| 1-(5-Isoquinolinesulfonyl)-2-methylpiperazine induces apoptosis in human neuroblastoma cells, SH-SY5Y, through a p53-dependent pathway F Ronca, SL Chan, CY Victor Journal of Biological Chemistry 272 (7), 4252-4260, 1997 | 81 | 1997 |
| Chelerythrine induces apoptosis through a Bax/Bak-independent mitochondrial mechanism KF Wan, SL Chan, SK Sukumaran, MC Lee, CY Victor Journal of biological chemistry 283 (13), 8423-8433, 2008 | 80 | 2008 |
| Chelerythrine and sanguinarine dock at distinct sites on BclXL that are not the classic BH3 binding cleft YH Zhang, A Bhunia, KF Wan, MC Lee, SL Chan, VCK Yu, YK Mok Journal of molecular biology 364 (3), 536-549, 2006 | 77 | 2006 |
| BCL6 promotes glioma and serves as a therapeutic target L Xu, Y Chen, M Dutra-Clarke, A Mayakonda, M Hazawa, SE Savinoff, ... Proceedings of the National Academy of Sciences 114 (15), 3981-3986, 2017 | 69 | 2017 |
| The Caenorhabditis elegansSex-determining Protein FEM-2 and Its Human Homologue, hFEM-2, Are Ca2+/Calmodulin-dependent Protein Kinase Phosphatases That Promote Apoptosis KML Tan, SL Chan, KO Tan, CY Victor Journal of Biological Chemistry 276 (47), 44193-44202, 2001 | 66 | 2001 |
| Acquired resistance to FGFR inhibitor in diffuse-type gastric cancer through an AKT-independent PKC-mediated phosphorylation of GSK3β WM Lau, E Teng, KK Huang, JW Tan, K Das, Z Zang, T Chia, M Teh, ... Molecular cancer therapeutics 17 (1), 232-242, 2018 | 47 | 2018 |
| Enhanced In Vivo Homing of Uncultured and Selectively Amplified Cord Blood CD34+ Cells by Cotransplantation with Cord Blood-Derived Unrestricted Somatic … SL Chan, M Choi, S Wnendt, M Kraus, E Teng, HF Leong, S Merchav Stem Cells 25 (2), 529-536, 2007 | 47 | 2007 |
| RACK1 down-regulates levels of the pro-apoptotic protein Fem1b in apoptosis-resistant colon cancer cells MC Subauste, T Ventura-Holman, L Du, JS Subauste, SL Chan, VC Yu, ... Cancer biology & therapy 8 (23), 2295-2303, 2009 | 46 | 2009 |
| F1Aα, a Death Receptor-binding Protein Homologous to theCaenorhabditis elegans Sex-determining Protein, FEM-1, Is a Caspase Substrate That Mediates Apoptosis SL Chan, KO Tan, L Zhang, KSY Yee, F Ronca, MY Chan, CY Victor Journal of Biological Chemistry 274 (45), 32461-32468, 1999 | 43 | 1999 |
| Valproic acid enhances the engraftability of human umbilical cord blood hematopoietic stem cells expanded under serum‐free conditions LF Seet, E Teng, YS Lai, J Laning, M Kraus, S Wnendt, S Merchav, ... European journal of haematology 82 (2), 124-132, 2009 | 41 | 2009 |
| Psychiatric illness, personality traits and the irritable bowel syndrome KM Fock, CN Chew, LK Tay, LH Peh, S Chan, EP Pang Annals of the Academy of Medicine, Singapore 30 (6), 611-614, 2001 | 41 | 2001 |
| The Caenorhabditis elegans sex determination protein FEM-1 is a CED-3 substrate that associates with CED-4 and mediates apoptosis in mammalian cells SL Chan, KSY Yee, KML Tan, CY Victor Journal of Biological Chemistry 275 (24), 17925-17928, 2000 | 40 | 2000 |
| Clinical translation of patient-derived tumour organoids-bottlenecks and strategies MA Foo, M You, SL Chan, G Sethi, GK Bonney, WP Yong, EKH Chow, ... Biomarker Research 10 (1), 10, 2022 | 38 | 2022 |
Jimmy So Bok-YanProfessor, Department of Surgery, National University of Singapore, SingaporeVerified email at nus.edu.sg
