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Wang Chao
Wang Chao
Verified email at scripps.edu
Title
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Year
Structural insights into the redox-regulated dynamic conformations of human protein disulfide isomerase
C Wang, W Li, J Ren, J Fang, H Ke, W Gong, W Feng, C Wang
Antioxidants & redox signaling 19 (1), 36-45, 2013
2302013
Human protein-disulfide isomerase is a redox-regulated chaperone activated by oxidation of domain a′
C Wang, J Yu, L Huo, L Wang, W Feng, C Wang
Journal of Biological Chemistry 287 (2), 1139-1149, 2012
1452012
Plasticity of human protein disulfide isomerase: evidence for mobility around the X-linker region and its functional significance
C Wang, S Chen, X Wang, L Wang, AK Wallis, RB Freedman, C Wang
Journal of Biological Chemistry 285 (35), 26788-26797, 2010
772010
Compact conformations of human protein disulfide isomerase
S Yang, X Wang, L Cui, X Ding, L Niu, F Yang, C Wang, C Wang, J Lou
PloS one 9 (8), e103472, 2014
382014
Bridging Genomics to Phenomics at Atomic Resolution through Variation Spatial Profiling
C Wang, WE Balch
Cell reports 24 (8), 2013-2028. e6, 2018
372018
Quantitating the epigenetic transformation contributing to cholesterol homeostasis using Gaussian process
C Wang, SM Scott, K Subramanian, S Loguercio, P Zhao, H Darren M., ...
Nature Communications 10, 5052, 2019
242019
Individualized Management of Genetic Diversity in Niemann-Pick C1 through Modulation of the Hsp70 Chaperone System
C Wang, SM Scott, S Sun, P Zhao, DM Hutt, H Shao, JE Gestwicki, ...
Human Molecular Genetics, 2020
192020
Spatial covariance analysis reveals the residue-by-residue thermodynamic contribution of variation to the CFTR fold
F Anglès, C Wang, WE Balch
Communications Biology 5 (1), 356, 2022
122022
Leveraging Population Genomics for Individualized Correction of the Hallmarks of Alpha-1 Antitrypsin Deficiency
C Wang, P Zhao, S Sun, J Teckman, WE Balch
Chronic Obstr Pulm Dis. 7 (3), 224-246, 2020
92020
Capturing the conversion of the pathogenic alpha-1-antitrypsin fold by ATF6 enhanced proteostasis
S Sun, C Wang, P Zhao, GM Kline, JMD Grandjean, X Jiang, ...
Cell chemical biology 30 (1), 22-42. e5, 2023
82023
Triangulating variation in the population to define mechanisms for precision management of genetic disease
C Wang, F Anglès, WE Balch
Structure 30 (8), 1190-1207. e5, 2022
72022
Measuring the effect of histone deacetylase inhibitors (HDACi) on the secretion and activity of alpha-1 antitrypsin
C Wang, M Bouchecareilh, WE Balch
Methods in Molecular Biology (Alpha-1 Antitrypsin Deficiency), 185-193, 2017
72017
Covariant fitness clusters reveal structural evolution of SARS-CoV-2 polymerase across the human population
C Wang, N Elghobashi-Meinhardt, WE Balch
bioRxiv, 2022.01. 07.475295, 2022
62022
Managing the Adaptive Proteostatic Landscape: Restoring Resilience in Alpha-1 Antitrypsin Deficiency
C Wang, WE Balch
Respiratory Medicine (Alpha-1 Antitrypsin Role in Health and Disease), 53-83, 2016
62016
Profiling Genetic Diversity Reveals the Molecular Basis for Balancing Function with Misfolding in Alpha-1 Antitrypsin
C Wang, Z Pei, S Sun, X Wang, WE Balch
bioRxiv, 2022
42022
Understanding the host-pathogen evolutionary balance through Gaussian process modeling of SARS-CoV-2
S Loguercio, BC Calverley, C Wang, D Shak, P Zhao, S Sun, ...
Patterns 4 (8), 2023
22023
COPII cage assembly factor Sec13 integrates information flow regulating endomembrane function in response to human variation
F Anglès, V Gupta, C Wang, WE Balch
Scientific Reports 14 (1), 10160, 2024
2024
Tracing genetic diversity captures the molecular basis of misfolding disease
P Zhao, C Wang, S Sun, X Wang, WE Balch
Nature Communications 15 (1), 3333, 2024
2024
Spatial covariance analysis reveals the residue-by-residue thermodynamic contribution of variation to the CFTR fold
A Frédéric, C Wang, WE Balch
Communications Biology 5 (1), 2022
2022
Methods for disease treatment and drug discovery
C Wang, WE Balch
US Patent App. 17/266,922, 2021
2021
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Articles 1–20