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Christopher Hulme
Christopher Hulme
Professor Drug Discovery/Medicinal Chemistry, University of Arizona
Verified email at pharmacy.arizona.edu
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Year
Maximizing synthetic efficiency: multi-component transformations lead the way
H Bienayme, C Hulme, G Oddon, P Schmitt
Chemistry - A European Journal 6 (18), 3321-29, 2000
14442000
" Multi-component reactions: emerging chemistry in drug discovery"'from xylocain to crixivan'
C Hulme, V Gore
Current medicinal chemistry 10 (1), 51-80, 2003
12772003
New 4-point pharmacophore method for molecular similarity and diversity applications: overview of the method and applications, including a novel approach to the design of …
JS Mason, I Morize, PR Menard, DL Cheney, C Hulme, RF Labaudiniere
Journal of medicinal chemistry 42 (17), 3251-3264, 1999
5111999
Hypervalent iodine chemistry: new oxidation reactions using the iodosylbenzene− trimethylsilyl azide reagent combination. Direct α-and β-azido functionalization of …
P Magnus, J Lacour, PA Evans, MB Roe, C Hulme
Journal of the American Chemical Society 118 (14), 3406-3418, 1996
1891996
The design, synthesis, and evaluation of 8 hybrid DFG-out allosteric kinase inhibitors: A structural analysis of the binding interactions of Gleevec®, Nexavar®, and BIRB-796
J Dietrich, C Hulme, LH Hurley
Bioorganic & medicinal chemistry 18 (15), 5738-5748, 2010
1812010
Novel safety-catch linker and its application with a Ugi/De-BOC/Cyclization (UDC) strategy to access carboxylic acids, 1, 4-benzodiazepines, diketopiperazines, ketopiperazines …
C Hulme, J Peng, G Morton, JM Salvino, T Herpin, R Labaudiniere
Tetrahedron letters 39 (40), 7227-7230, 1998
1661998
Novel applications of ethyl glyoxalate with the Ugi MCR
C Hulme, MP Cherrier
Tetrahedron letters 40 (29), 5295-5299, 1999
1621999
Emerging molecular diversity from the intra-molecular Ugi reaction: iterative efficiency in medicinal chemistry
C Hulme, J Dietrich
Molecular diversity 13, 195-207, 2009
1552009
Improved procedure for the solution phase preparation of 1, 4-benzodiazepine-2, 5-dione libraries via Armstrong's convertible isonitrile and the Ugi reaction
C Hulme, J Peng, SY Tang, CJ Burns, I Morize, R Labaudiniere
The Journal of Organic Chemistry 63 (22), 8021-8023, 1998
1551998
The solution phase synthesis of diketopiperazine libraries via the Ugi reaction: novel application of Armstrong's convertible isonitrile
C Hulme, MM Morrissette, FA Volz, CJ Burns
Tetrahedron letters 39 (10), 1113-1116, 1998
1511998
Recent advances in the design, synthesis, and biological evaluation of selective DYRK1A inhibitors: a new avenue for a disease modifying treatment of Alzheimer’s?
B Smith, F Medda, V Gokhale, T Dunckley, C Hulme
ACS chemical neuroscience 3 (11), 857-872, 2012
1442012
Two-step solution-phase synthesis of novel benzimidazoles utilizing a UDC (Ugi/de-Boc/cyclize) strategy
P Tempest, V Ma, S Thomas, Z Hua, MG Kelly, C Hulme
Tetrahedron Letters 42 (30), 4959-4962, 2001
1272001
Ugi/Aldol Sequence: Expeditious Entry to Several Families of Densely Substituted Nitrogen Heterocycles.
CH Z Xu, F De Moliner, AP Cappelli
Angewandte Chemie, 8161-8164, 2012
116*2012
Emerging approaches for the syntheses of bicyclic imidazo [1, 2-x]-heterocycles
C Hulme, YS Lee
Molecular Diversity 12, 1-15, 2008
1042008
Two-step solution-phase synthesis of novel quinoxalinones utilizing a UDC (Ugi/de-Boc/cyclize) strategy
T Nixey, P Tempest, C Hulme
Tetrahedron letters 43 (9), 1637-1639, 2002
1042002
MCC/SNAr methodology. Part 1: Novel access to a range of heterocyclic cores
P Tempest, V Ma, MG Kelly, W Jones, C Hulme
Tetrahedron Letters 42 (30), 4963-4968, 2001
1042001
. alpha.-Azidonation of Amides, Carbamates, and Ureas with the Iodosylbenzene/Trimethylsilyl Azide Reagent Combination: N-Acyliminium Ion Precursors
P Magnus, C Hulme, W Weber
Journal of the American Chemical Society 116 (10), 4501-4502, 1994
1001994
Dyrk1 inhibition improves Alzheimer's disease‐like pathology
C Branca, DM Shaw, R Belfiore, V Gokhale, AY Shaw, C Foley, B Smith, ...
Aging cell 16 (5), 1146-1154, 2017
982017
Novel applications of carbon dioxide/MeOH for the synthesis of hydantoins and cyclic ureas via the Ugi reaction
C Hulme, L Ma, JJ Romano, G Morton, SY Tang, MP Cherrier, S Choi, ...
Tetrahedron Letters 41 (12), 1889-1893, 2000
972000
Sequential Ugi/Strecker reactions via microwave assisted organic synthesis: novel 3-center-4-component and 3-center-5-component multi-component reactions
T Masquelin, H Bui, B Brickley, G Stephenson, J Schwerkoske, C Hulme
Tetrahedron letters 47 (17), 2989-2991, 2006
922006
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