| Recognition of the iso-ADP-ribose moiety in poly (ADP-ribose) by WWE domains suggests a general mechanism for poly (ADP-ribosyl) ation-dependent ubiquitination Z Wang, GA Michaud, Z Cheng, Y Zhang, TR Hinds, E Fan, F Cong, W Xu Genes and Development 26 (3), 235, 2012 | 270 | 2012 |
| MeCP2 suppresses nuclear microRNA processing and dendritic growth by regulating the DGCR8/Drosha complex TL Cheng, Z Wang, Q Liao, Y Zhu, WH Zhou, W Xu, Z Qiu Developmental cell 28 (5), 547-560, 2014 | 265 | 2014 |
| Allosteric activation of the RNF146 ubiquitin ligase by a poly (ADP-ribosyl) ation signal PA DaRosa, Z Wang, X Jiang, JN Pruneda, F Cong, RE Klevit, W Xu Nature 517 (7533), 223, 2015 | 204 | 2015 |
| Robust design and optimization of retroaldol enzymes EA Althoff, L Wang, L Jiang, L Giger, JK Lassila, Z Wang, M Smith, S Hari, ... Protein science 21 (5), 717-726, 2012 | 192 | 2012 |
| Activation of tumor suppressor protein PP2A inhibits KRAS-driven tumor growth J Sangodkar, A Perl, R Tohme, J Kiselar, DB Kastrinsky, N Zaware, ... The Journal of clinical investigation 127 (6), 2081-2090, 2017 | 180 | 2017 |
| Selective PP2A Enhancement through Biased Heterotrimer Stabilization D Leonard, W Huang, S Izadmehr, CM O’Connor, DD Wiredja, Z Wang, ... Cell 181, 1-14, 2020 | 126 | 2020 |
| Streptavidin and its biotin complex at atomic resolution I Le Trong, Z Wang, DE Hyre, TP Lybrand, PS Stayton, RE Stenkamp Acta Crystallographica Section D: Biological Crystallography 67 (9), 813-821, 2011 | 124 | 2011 |
| Oncoprotein CIP 2A is stabilized via interaction with tumor suppressor PP 2A/B56 J Wang, J Okkeri, K Pavic, Z Wang, O Kauko, T Halonen, G Sarek, ... EMBO reports 18 (3), 437-450, 2017 | 106 | 2017 |
| Crystal structure of a membrane-bound O-acyltransferase D Ma, Z Wang, CN Merrikh, KS Lang, P Lu, X Li, H Merrikh, Z Rao, W Xu Nature 562 (7726), 286-290, 2018 | 98 | 2018 |
| Multi-input chemical control of protein dimerization for programming graded cellular responses GW Foight, Z Wang, CT Wei, P Jr Greisen, KM Warner, ... Nature biotechnology 37 (10), 1209-1216, 2019 | 74 | 2019 |
| Crystal structure of a PP2A B56-BubR1 complex and its implications for PP2A substrate recruitment and localization J Wang, Z Wang, T Yu, H Yang, DM Virshup, GJPL Kops, SH Lee, W Zhou, ... Protein & cell 7 (7), 516-526, 2016 | 73 | 2016 |
| The highly recurrent PP2A Aα-subunit mutation P179R alters protein structure and impairs PP2A enzyme function to promote endometrial tumorigenesis SE Taylor, CM O'Connor, Z Wang, G Shen, H Song, D Leonard, ... Cancer research 79 (16), 4242-4257, 2019 | 46 | 2019 |
| Structural basis of the Norrin-Frizzled 4 interaction Guobo Shen, Jiyuan Ke, Zhizhi Wang, Zhihong Cheng, Xin Gu, Yuquan Wei ... Cell Research, 2015 | 45 | 2015 |
| Structural basis of the interaction between tuberous sclerosis complex 1 (TSC1) and Tre2-Bub2-Cdc16 domain family member 7 (TBC1D7) J Qin, Z Wang, M Hoogeveen-Westerveld, G Shen, W Gong, M Nellist, ... Journal of Biological Chemistry 291 (16), 8591-8601, 2016 | 40 | 2016 |
| Inactivation of PP2A by a recurrent mutation drives resistance to MEK inhibitors CM O’Connor, D Leonard, D Wiredja, RA Avelar, Z Wang, D Schlatzer, ... Oncogene 39, 703-717, 2020 | 34 | 2020 |
| Identification of ICAT as an APC inhibitor, revealing Wnt-dependent inhibition of APC-axin interaction L Ji, B Lu, Z Wang, Z Yang, J Reece-Hoyes, C Russ, W Xu, F Cong Molecular cell 72 (1), 37-47. e4, 2018 | 31 | 2018 |
| Crystal structure of the yeast TSC1 core domain and implications for tuberous sclerosis pathological mutations W Sun, YJ Zhu, Z Wang, Q Zhong, F Gao, J Lou, W Gong, W Xu Nature communications 4 (1), 2135, 2013 | 31 | 2013 |
| Crystallographic and biochemical analysis of the mouse poly (ADP-ribose) glycohydrolase Z Wang, JP Gagne, GG Poirier, W Xu PLoS One 9 (1), e86010, 2014 | 29 | 2014 |
| Crystal structure of a tankyrase 1–telomere repeat factor 1 complex B Li, R Qiao, Z Wang, W Zhou, X Li, W Xu, Z Rao Acta Crystallographica Section F: Structural Biology Communications 72 (4 …, 2016 | 24 | 2016 |
| Cryo-EM structure of human Wntless in complex with Wnt3a Q Zhong, Y Zhao, F Ye, Z Xiao, G Huang, M Xu, Y Zhang, X Zhan, K Sun, ... Nature Communications 12 (1), 4541, 2021 | 22 | 2021 |
