| Structural insight into the core of CAD, the multifunctional protein leading de novo pyrimidine biosynthesis M Moreno-Morcillo, A Grande-García, A Ruiz-Ramos, F del Cano-Ochoa, ... Structure 25 (6), 912-923. e5, 2017 | 51 | 2017 |
| CAD, a multienzymatic protein at the head of de novo pyrimidine biosynthesis F del Caño-Ochoa, M Moreno-Morcillo, S Ramón-Maiques Macromolecular Protein Complexes II: Structure and Function, 505-538, 2019 | 30 | 2019 |
| Deciphering CAD: Structure and function of a mega‐enzymatic pyrimidine factory in health and disease F del Caño‐Ochoa, S Ramón‐Maiques Protein Science 30 (10), 1995-2008, 2021 | 23 | 2021 |
| Characterization of the catalytic flexible loop in the dihydroorotase domain of the human multi-enzymatic protein CAD F del Caño-Ochoa, A Grande-García, M Reverte-López, M D’Abramo, ... Journal of Biological Chemistry 293 (49), 18903-18913, 2018 | 21 | 2018 |
| Mechanisms of feedback inhibition and sequential firing of active sites in plant aspartate transcarbamoylase L Bellin, F Del Caño-Ochoa, A Velázquez-Campoy, T Möhlmann, ... Nature communications 12 (1), 947, 2021 | 20 | 2021 |
| Cell-based analysis of CAD variants identifies individuals likely to benefit from uridine therapy F del Caño-Ochoa, BG Ng, M Abedalthagafi, M Almannai, RD Cohn, ... Genetics in Medicine 22 (10), 1598-1605, 2020 | 19 | 2020 |
| The GATA3 X308_Splice breast cancer mutation is a hormone context-dependent oncogenic driver N Hruschka, M Kalisz, M Subijana, O Graña-Castro, F Del Cano-Ochoa, ... Oncogene 39 (32), 5455-5467, 2020 | 19 | 2020 |
| Afatinib exerts immunomodulatory effects by targeting the pyrimidine biosynthesis enzyme CAD HF Tu, CJ Ko, CT Lee, CF Lee, SW Lan, HH Lin, HY Lin, CC Ku, DY Lee, ... Cancer Research 81 (12), 3270-3282, 2021 | 16 | 2021 |
| Functional and structural deficiencies of Gemin5 variants associated with neurological disorders R Francisco-Velilla, A Embarc-Buh, F del Caño-Ochoa, S Abellan, M Vilar, ... Life Science Alliance 5 (7), 2022 | 8 | 2022 |
| Insight on molecular pathogenesis and pharmacochaperoning potential in phosphomannomutase 2 deficiency, provided by novel human phosphomannomutase 2 structures A Briso‐Montiano, F Del Caño‐Ochoa, A Vilas, A Velázquez‐Campoy, ... Journal of Inherited Metabolic Disease 45 (2), 318-333, 2022 | 8 | 2022 |
| Beyond genetics: Deciphering the impact of missense variants in CAD deficiency F del Caño‐Ochoa, BG Ng, A Rubio‐del‐Campo, S Mahajan, MP Wilson, ... Journal of inherited metabolic disease 46 (6), 1170-1185, 2023 | 6 | 2023 |
| A functional platform for the selection of pathogenic variants of PMM2 amenable to rescue via the use of pharmacological chaperones C Segovia‐Falquina, A Vilas, F Leal, F del Caño‐Ochoa, EP Kirk, ... Human Mutation 43 (10), 1430-1442, 2022 | 4 | 2022 |
| The multienzymatic protein CAD leading the de novo biosynthesis of pyrimidines localizes exclusively in the cytoplasm and does not translocate to the nucleus F del Caño-Ochoa, S Ramón-Maiques Nucleosides, Nucleotides & Nucleic Acids 39 (10-12), 1320-1334, 2020 | 4 | 2020 |
| Phosphorylation of T897 in the dimerization domain of Gemin5 modulates protein interactions and translation regulation R Francisco-Velilla, A Embarc-Buh, S Abellan, F del Caño-Ochoa, ... Computational and Structural Biotechnology Journal 20, 6182-6191, 2022 | 3 | 2022 |
| UMP inhibition and sequential firing in aspartate transcarbamoylase open ways to regulate plant growth L Bellin, F del Caño-Ochoa, A Velázquez-Campoy, T Möhlmann, ... bioRxiv, 2020.07. 17.208231, 2020 | 1 | 2020 |
| Novel bi-allelic CAD variants cause epileptic encephalopathy responsive to triacetyluridine supplementation K Anderson, K Wiltrout, C Giummo, SB Wortmann, H Freeze, ... Molecular Genetics and Metabolism 141 (4), 108204, 2024 | | 2024 |
| Biallelic hypomorphic variants in CAD cause uridine‐responsive macrocytic anaemia with elevated haemoglobin‐A2 O Steinberg‐Shemer, J Yacobovich, S Noy‐Lotan, O Dgany, T Krasnov, ... British Journal of Haematology 204 (3), 1067-1071, 2024 | | 2024 |
| A Tailored Strategy to Crosslink the Aspartate Transcarbamoylase Domain of the Multienzymatic Protein CAD F del Caño-Ochoa, A Rubio-del-Campo, S Ramón-Maiques Molecules 28 (2), 660, 2023 | | 2023 |
| Functional characterization of CAD, an antitumoral target controlling the de novo pyrimidine biosynthesis F del Caño Ochoa Universidad Autónoma de Madrid, 2019 | | 2019 |
