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Laura Garcia-Prat
Laura Garcia-Prat
Princess Margaret Cancer Centre, University Health Network
Verified email at uhnresearch.ca
Title
Cited by
Cited by
Year
Autophagy maintains stemness by preventing senescence
L García-Prat, M Martínez-Vicente, E Perdiguero, L Ortet, ...
Nature 529 (7584), 37-42, 2016
12232016
Geriatric muscle stem cells switch reversible quiescence into senescence
P Sousa-Victor, S Gutarra, L García-Prat, J Rodriguez-Ubreva, L Ortet, ...
Nature 506 (7488), 316-321, 2014
9602014
Control of satellite cell function in muscle regeneration and its disruption in ageing
P Sousa-Victor, L García-Prat, P Muñoz-Cánoves
Nature Reviews Molecular Cell Biology 23 (3), 204-226, 2022
1822022
Muscle stem cell aging: regulation and rejuvenation
P Sousa-Victor, L García-Prat, AL Serrano, E Perdiguero, ...
Trends in Endocrinology & Metabolism 26 (6), 287-296, 2015
1752015
Functional dysregulation of stem cells during aging: a focus on skeletal muscle stem cells
L García‐Prat, P Sousa‐Victor, P Muñoz‐Cánoves
The FEBS journal 280 (17), 4051-4062, 2013
1542013
Proteostatic and metabolic control of stemness
L García-Prat, P Sousa-Victor, P Muñoz-Cánoves
Cell Stem Cell 20 (5), 593-608, 2017
1182017
FoxO maintains a genuine muscle stem-cell quiescent state until geriatric age
L García-Prat, E Perdiguero, S Alonso-Martin, S Dell’Orso, ...
Nature cell biology 22 (11), 1307-1318, 2020
1122020
Sestrin prevents atrophy of disused and aging muscles by integrating anabolic and catabolic signals
J Segalés, E Perdiguero, AL Serrano, P Sousa-Victor, L Ortet, M Jardí, ...
Nature communications 11 (1), 189, 2020
1102020
Enhancer Hijacking Drives Oncogenic BCL11B Expression in Lineage-Ambiguous Stem Cell Leukemia
LE Montefiori, S Bendig, Z Gu, X Chen, P Pölönen, X Ma, A Murison, ...
Cancer discovery 11 (11), 2846-2867, 2021
972021
Relapse-fated latent diagnosis subclones in acute B lineage leukemia are drug tolerant and possess distinct metabolic programs
SM Dobson, L García-Prat, RJ Vanner, J Wintersinger, E Waanders, Z Gu, ...
Cancer discovery 10 (4), 568-587, 2020
902020
Sphingolipid modulation activates proteostasis programs to govern human hematopoietic stem cell self-renewal
SZ Xie, L Garcia-Prat, V Voisin, R Ferrari, OI Gan, E Wagenblast, ...
Cell stem cell 25 (5), 639-653. e7, 2019
872019
TFEB-mediated endolysosomal activity controls human hematopoietic stem cell fate
L García-Prat, KB Kaufmann, F Schneiter, V Voisin, A Murison, J Chen, ...
Cell stem cell 28 (10), 1838-1850. e10, 2021
812021
Dysfunctional autophagy is a driver of muscle stem cell functional decline with aging
L García-Prat, P Muñoz-Cánoves, M Martinez-Vicente
Autophagy 12 (3), 612-613, 2016
632016
The transition from quiescent to activated states in human hematopoietic stem cells is governed by dynamic 3D genome reorganization
N Takayama, A Murison, S Takayanagi, C Arlidge, S Zhou, L Garcia-Prat, ...
Cell stem cell 28 (3), 488-501. e10, 2021
582021
Mapping the cellular origin and early evolution of leukemia in Down syndrome
E Wagenblast, J Araújo, OI Gan, SK Cutting, A Murison, G Krivdova, ...
Science 373 (6551), eabf6202, 2021
482021
Aging, metabolism and stem cells: Spotlight on muscle stem cells
L García-Prat, P Munoz-Canoves
Molecular and cellular endocrinology 445, 109-117, 2017
402017
Sphingosine-1-phosphate receptor 3 potentiates inflammatory programs in normal and leukemia stem cells to promote differentiation
SZ Xie, KB Kaufmann, W Wang, M Chan-Seng-Yue, OI Gan, E Laurenti, ...
Blood cancer discovery 2 (1), 32-53, 2021
362021
Biological and therapeutic implications of a unique subtype of NPM1 mutated AML
AS Mer, EM Heath, SA Madani Tonekaboni, N Dogan-Artun, SK Nair, ...
Nature Communications 12 (1), 1054, 2021
342021
A latent subset of human hematopoietic stem cells resists regenerative stress to preserve stemness
KB Kaufmann, AGX Zeng, E Coyaud, L Garcia-Prat, E Papalexi, ...
Nature immunology 22 (6), 723-734, 2021
332021
The metabolic enzyme hexokinase 2 localizes to the nucleus in AML and normal haematopoietic stem and progenitor cells to maintain stemness
GE Thomas, G Egan, L García-Prat, A Botham, V Voisin, PS Patel, ...
Nature cell biology 24 (6), 872-884, 2022
312022
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