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Arthur Marivin
Arthur Marivin
Principal Scientist - Tectonic Therapeutics
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Year
Daple is a novel non-receptor GEF required for trimeric G protein activation in Wnt signaling
N Aznar, KK Midde, Y Dunkel, I Lopez-Sanchez, Y Pavlova, A Marivin, ...
Elife 4, e07091, 2015
1242015
Revealing the activity of trimeric G-proteins in live cells with a versatile biosensor design
M Maziarz, JC Park, A Leyme, A Marivin, A Garcia-Lopez, PP Patel, ...
Cell 182 (3), 770-785. e16, 2020
602020
Cellular inhibitor of apoptosis protein-1 (cIAP1) can regulate E2F1 transcription factor-mediated control of cyclin transcription
J Cartier, J Berthelet, A Marivin, S Gemble, V Edmond, S Plenchette, ...
Journal of Biological Chemistry 286 (30), 26406-26417, 2011
512011
Molecular mechanism of Gαi activation by non-GPCR proteins with a Gα-binding and activating motif
AI de Opakua, K Parag-Sharma, V DiGiacomo, N Merino, A Leyme, ...
Nature communications 8 (1), 15163, 2017
462017
Integrins activate trimeric G proteins via the nonreceptor protein GIV/Girdin
A Leyme, A Marivin, L Perez-Gutierrez, LT Nguyen, M Garcia-Marcos
Journal of Cell Biology 210 (7), 1165-1184, 2015
462015
When heterotrimeric G proteins are not activated by G protein-coupled receptors: structural insights and evolutionary conservation
V DiGiacomo, A Marivin, M Garcia-Marcos
Biochemistry 57 (3), 255-257, 2018
352018
The inhibitor of apoptosis (IAPs) in adaptive response to cellular stress
A Marivin, J Berthelet, S Plenchette, L Dubrez
Cells 1 (4), 711-737, 2012
332012
Dominant-negative Gα subunits are a mechanism of dysregulated heterotrimeric G protein signaling in human disease
A Marivin, A Leyme, K Parag-Sharma, V DiGiacomo, AY Cheung, ...
Science signaling 9 (423), ra37-ra37, 2016
322016
Evolutionary conservation of a GPCR-independent mechanism of trimeric G protein activation
BD Coleman, A Marivin, K Parag-Sharma, V DiGiacomo, S Kim, ...
Molecular biology and evolution 33 (3), 820-837, 2016
322016
Atypical activation of the G protein Gαq by the oncogenic mutation Q209P
M Maziarz, A Leyme, A Marivin, A Luebbers, PP Patel, Z Chen, ...
Journal of Biological Chemistry 293 (51), 19586-19599, 2018
312018
cIAP1 regulates TNF-mediated cdc42 activation and filopodia formation
A Marivin, J Berthelet, J Cartier, C Paul, S Gemble, A Morizot, W Boireau, ...
Oncogene 33 (48), 5534-5545, 2014
272014
Specific inhibition of GPCR-independent G protein signaling by a rationally engineered protein
A Leyme, A Marivin, M Maziarz, V DiGiacomo, MP Papakonstantinou, ...
Proceedings of the National Academy of Sciences 114 (48), E10319-E10328, 2017
242017
GIV/Girdin (Gα-interacting, vesicle-associated protein/Girdin) creates a positive feedback loop that potentiates outside-in integrin signaling in cancer cells
A Leyme, A Marivin, M Garcia-Marcos
Journal of Biological Chemistry 291 (15), 8269-8282, 2016
232016
GPCR-independent activation of G proteins promotes apical cell constriction in vivo
A Marivin, V Morozova, I Walawalkar, A Leyme, DA Kretov, D Cifuentes, ...
Journal of cell biology 218 (5), 1743-1763, 2019
202019
DAPLE and MPDZ bind to each other and cooperate to promote apical cell constriction
A Marivin, M Garcia-Marcos
Molecular biology of the cell 30 (16), 1900-1910, 2019
192019
Membrane recruitment of the non-receptor protein GIV/girdin (Gα-interacting, vesicle-associated protein/girdin) is sufficient for activating heterotrimeric G protein signaling
K Parag-Sharma, A Leyme, V DiGiacomo, A Marivin, S Broselid, ...
Journal of Biological Chemistry 291 (53), 27098-27111, 2016
192016
Optogenetic activation of heterotrimeric G-proteins by LOV2GIVe, a rationally engineered modular protein
M Garcia-Marcos, K Parag-Sharma, A Marivin, M Maziarz, A Luebbers, ...
Elife 9, e60155, 2020
162020
Different biochemical properties explain why two equivalent Gα subunit mutants cause unrelated diseases
A Leyme, A Marivin, J Casler, LT Nguyen, M Garcia-Marcos
Journal of Biological Chemistry 289 (32), 21818-21827, 2014
152014
IAPs: a central element in the NF-κB activating signaling pathway
J Cartier, A Marivin, J Berthelet, L Dubrez
Medecine Sciences: M/S 28 (1), 69-75, 2012
142012
DAPLE protein inhibits nucleotide exchange on Gαs and Gαq via the same motif that activates Gαi
A Marivin, M Maziarz, J Zhao, V DiGiacomo, IO Calvo, EA Mann, J Ear, ...
Journal of Biological Chemistry 295 (8), 2270-2284, 2020
122020
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