An abbreviated protocol for multilineage neural differentiation of murine embryonic stem cells and its perturbation by methyl mercury PT Theunissen, SHW Schulpen, DAM Van Dartel, SAB Hermsen, ... Reproductive toxicology 29 (4), 383-392, 2010 | 74 | 2010 |
Time-response evaluation by transcriptomics of methylmercury effects on neural differentiation of murine embryonic stem cells PT Theunissen, JLA Pennings, JF Robinson, SMH Claessen, ... Toxicological Sciences 122 (2), 437-447, 2011 | 69 | 2011 |
Transcriptomic concentration-response evaluation of valproic acid, cyproconazole, and hexaconazole in the neural embryonic stem cell test (ESTn) PT Theunissen, JF Robinson, JLA Pennings, E de Jong, SMH Claessen, ... Toxicological Sciences 125 (2), 430-438, 2012 | 65 | 2012 |
Complementary detection of embryotoxic properties of substances in the neural and cardiac embryonic stem cell tests PT Theunissen, JLA Pennings, DAM van Dartel, JF Robinson, ... toxicological sciences 132 (1), 118-130, 2013 | 55 | 2013 |
Comparison of MeHg-induced toxicogenomic responses across in vivo and in vitro models used in developmental toxicology JF Robinson, PT Theunissen, DAM van Dartel, JL Pennings, ... Reproductive toxicology 32 (2), 180-188, 2011 | 38 | 2011 |
Compound-specific effects of diverse neurodevelopmental toxicants on global gene expression in the neural embryonic stem cell test (ESTn) PT Theunissen, JF Robinson, JLA Pennings, MH van Herwijnen, ... Toxicology and applied pharmacology 262 (3), 330-340, 2012 | 37 | 2012 |
Comparison of rat and rabbit embryo–fetal developmental toxicity data for 379 pharmaceuticals: on the nature and severity of developmental effects PT Theunissen, S Beken, BK Beyer, WJ Breslin, GD Cappon, CL Chen, ... Critical reviews in toxicology 46 (10), 900-910, 2016 | 27 | 2016 |
Comparing rat and rabbit embryo-fetal developmental toxicity data for 379 pharmaceuticals: on systemic dose and developmental effects. Critical reviews in toxicology 21, 1-13, 2016 | 21* | 2016 |
An optimized gene set for transcriptomics based neurodevelopmental toxicity prediction in the neural embryonic stem cell test JLA Pennings, PT Theunissen, AH Piersma Toxicology 300 (3), 158-167, 2012 | 21 | 2012 |
Valproic acid-induced gene expression responses in rat whole embryo culture and comparison across in vitro developmental and non-developmental models ECM Tonk, JF Robinson, A Verhoef, PT Theunissen, JLA Pennings, ... Reproductive Toxicology 41, 57-66, 2013 | 19 | 2013 |
Innovative approaches in the embryonic stem cell test (EST) PT Theunissen, AH Piersma Front Biosci 17, 1965-1975, 2012 | 18 | 2012 |
Toward a comparative retrospective analysis of rat and rabbit developmental toxicity studies for pharmaceutical compounds PT Theunissen, S Beken, GD Cappon, C Chen, AM Hoberman, ... Reproductive Toxicology 47, 27-32, 2014 | 15 | 2014 |
Analysis of exposure margins in developmental toxicity studies for detection of human teratogens PA Andrews, D Blanset, PL Costa, M Green, ML Green, A Jacobs, ... Regulatory Toxicology and Pharmacology 105, 62-68, 2019 | 14 | 2019 |
Applicability of organ-on-chip systems in toxicology and pharmacology MR Schneider, M Oelgeschlaeger, T Burgdorf, P van Meer, P Theunissen, ... Critical Reviews in Toxicology 51 (6), 540-554, 2021 | 13 | 2021 |
Dynamic changes in energy metabolism upon embryonic stem cell differentiation support developmental toxicant identification DAM van Dartel, SH Schulpen, PT Theunissen, A Bunschoten, ... Toxicology 324, 76-87, 2014 | 13 | 2014 |
Comparison of gene expression regulation in mouse-and human embryonic stem cell assays during neural differentiation and in response to valproic acid exposure SHW Schulpen, PT Theunissen, JLA Pennings, AH Piersma Reproductive Toxicology 56, 77-86, 2015 | 10 | 2015 |
Testing developmental toxicity in a second species: are the differences due to species or replication error? HM Braakhuis, PT Theunissen, W Slob, E Rorije, AH Piersma Regulatory Toxicology and Pharmacology 107, 104410, 2019 | 7 | 2019 |
DNA-repair-deficient Rad54/Rad54B mice are more sensitive to clastogens than wild-type mice AG Mahabir, M Schaap, P Theunissen, J van Benthem, J Essers, ... Toxicology letters 183 (1-3), 112-117, 2008 | 6 | 2008 |
Animal free applications in the development of cell-based therapies P van Meer, P Theunissen, T van den Hoorn, C Herberts, ... Authorea Preprints, 2020 | 2 | 2020 |
Bovine spermatozoa: An in vitro model for reproductive toxicity? MM Tegelenbosch-Schouten, S Arabi, D Balduzzi, JHM van Bilsen, ... Toxicology Letters, S216, 2006 | 2 | 2006 |