| Structure-guided multivalent nanobodies block SARS-CoV-2 infection and suppress mutational escape PA Koenig, H Das, H Liu, BM Kümmerer, FN Gohr, LM Jenster, ... Science 371 (6530), eabe6230, 2021 | 326 | 2021 |
| Amino acid residues in the N-terminal region of the PA subunit of influenza A virus RNA polymerase play a critical role in protein stability, endonuclease activity, cap binding … K Hara, FI Schmidt, M Crow, GG Brownlee Journal of virology 80 (16), 7789-7798, 2006 | 274 | 2006 |
| HDAC6 mediates an aggresome-like mechanism for NLRP3 and pyrin inflammasome activation VG Magupalli, R Negro, Y Tian, AV Hauenstein, G Di Caprio, W Skillern, ... Science 369 (6510), eaas8995, 2020 | 245 | 2020 |
| Exploiting nanobodies’ singular traits JR Ingram, FI Schmidt, HL Ploegh Annual review of immunology 36, 695-715, 2018 | 209 | 2018 |
| Vaccinia virus strains use distinct forms of macropinocytosis for host-cell entry J Mercer, S Knébel, FI Schmidt, J Crouse, C Burkard, A Helenius Proceedings of the National Academy of Sciences 107 (20), 9346-9351, 2010 | 201 | 2010 |
| Systematic functional analysis of SARS-CoV-2 proteins uncovers viral innate immune antagonists and remaining vulnerabilities M Hayn, M Hirschenberger, L Koepke, R Nchioua, JH Straub, S Klute, ... Cell reports 35 (7), 2021 | 191 | 2021 |
| Early IFN-α signatures and persistent dysfunction are distinguishing features of NK cells in severe COVID-19 B Krämer, R Knoll, L Bonaguro, M ToVinh, J Raabe, ... Immunity 54 (11), 2650-2669. e14, 2021 | 169 | 2021 |
| Molecular basis of caspase-1 polymerization and its inhibition by a new capping mechanism A Lu, Y Li, FI Schmidt, Q Yin, S Chen, TM Fu, AB Tong, HL Ploegh, Y Mao, ... Nature structural & molecular biology 23 (5), 416-425, 2016 | 157 | 2016 |
| A single domain antibody fragment that recognizes the adaptor ASC defines the role of ASC domains in inflammasome assembly FI Schmidt, A Lu, JW Chen, J Ruan, C Tang, H Wu, HL Ploegh Journal of Experimental Medicine 213 (5), 771-790, 2016 | 153 | 2016 |
| Vaccinia extracellular virions enter cells by macropinocytosis and acid‐activated membrane rupture FI Schmidt, CKE Bleck, A Helenius, J Mercer The EMBO journal 30 (17), 3647-3661, 2011 | 138 | 2011 |
| Poxvirus host cell entry FI Schmidt, CKE Bleck, J Mercer Current opinion in virology 2 (1), 20-27, 2012 | 128 | 2012 |
| Localized CD47 blockade enhances immunotherapy for murine melanoma JR Ingram, OS Blomberg, JT Sockolosky, L Ali, FI Schmidt, N Pishesha, ... Proceedings of the National Academy of Sciences 114 (38), 10184-10189, 2017 | 118 | 2017 |
| Vaccinia virus entry is followed by core activation and proteasome-mediated release of the immunomodulatory effector VH1 from lateral bodies FI Schmidt, CKE Bleck, L Reh, K Novy, B Wollscheid, A Helenius, ... Cell reports 4 (3), 464-476, 2013 | 104 | 2013 |
| The intra‐and extracellular functions of ASC specks BS Franklin, E Latz, FI Schmidt Immunological reviews 281 (1), 74-87, 2018 | 97 | 2018 |
| Cooperative vaccinia infection demonstrated at the single-cell level using FluidFM P Stiefel, FI Schmidt, P Dörig, P Behr, T Zambelli, JA Vorholt, J Mercer Nano letters 12 (8), 4219-4227, 2012 | 76 | 2012 |
| siRNA screen of early poxvirus genes identifies the AAA+ ATPase D5 as the virus genome-uncoating factor S Kilcher, FI Schmidt, C Schneider, M Kopf, A Helenius, J Mercer Cell host & microbe 15 (1), 103-112, 2014 | 71 | 2014 |
| Intracellular expression of camelid single-domain antibodies specific for influenza virus nucleoprotein uncovers distinct features of its nuclear localization J Ashour, FI Schmidt, L Hanke, J Cragnolini, M Cavallari, A Altenburg, ... Journal of virology 89 (5), 2792-2800, 2015 | 66 | 2015 |
| Disruption of Sphingolipid Biosynthesis Blocks Phagocytosis of Candida albicans FG Tafesse, A Rashidfarrokhi, FI Schmidt, E Freinkman, S Dougan, ... PLoS pathogens 11 (10), e1005188, 2015 | 62 | 2015 |
| A facile protocol for the immobilisation of vesicles, virus particles, bacteria, and yeast cells P Kuhn, K Eyer, T Robinson, FI Schmidt, J Mercer, PS Dittrich Integrative biology 4 (12), 1550-1555, 2012 | 62 | 2012 |
| Phenotypic lentivirus screens to identify functional single domain antibodies FI Schmidt, L Hanke, B Morin, R Brewer, V Brusic, SPJ Whelan, ... Nature microbiology 1 (8), 1-10, 2016 | 51 | 2016 |
Hidde PloeghSenior Investigator, Program in Cellular and Molecular Medicine, Boston Children's HospitalVerified email at childrens.harvard.edu
