| Ursolic acid induces apoptosis by activating p53 and caspase-3 gene expressions and suppressing NF-κB mediated activation of bcl-2 in B16F-10 melanoma cells KA Manu, G Kuttan International immunopharmacology 8 (7), 974-981, 2008 | 185 | 2008 |
| Celastrol inhibits tumor cell proliferation and promotes apoptosis through the activation of c-Jun N-terminal kinase and suppression of PI3 K/Akt signaling pathways R Kannaiyan, KA Manu, L Chen, F Li, P Rajendran, A Subramaniam, ... Apoptosis 16, 1028-1041, 2011 | 176 | 2011 |
| Isorhamnetin augments the anti-tumor effect of capeciatbine through the negative regulation of NF-κB signaling cascade in gastric cancer KA Manu, MK Shanmugam, L Ramachandran, F Li, KS Siveen, ... Cancer Letters 363 (1), 28-36, 2015 | 161 | 2015 |
| Inhibition of tumor progression by naturally occurring terpenoids G Kuttan, P Pratheeshkumar, KA Manu, R Kuttan Pharmaceutical biology 49 (10), 995-1007, 2011 | 160 | 2011 |
| First evidence that γ-tocotrienol inhibits the growth of human gastric cancer and chemosensitizes it to capecitabine in a xenograft mouse model through the modulation of NF-κB … KA Manu, MK Shanmugam, L Ramachandran, F Li, CW Fong, AP Kumar, ... Clinical Cancer Research 18 (8), 2220-2229, 2012 | 156 | 2012 |
| Simvastatin sensitizes human gastric cancer xenograft in nude mice to capecitabine by suppressing nuclear factor-kappa B-regulated gene products KA Manu, MK Shanmugam, F Li, L Chen, KS Siveen, KS Ahn, AP Kumar, ... Journal of molecular medicine 92, 267-276, 2014 | 152 | 2014 |
| Isorhamnetin inhibits proliferation and invasion and induces apoptosis through the modulation of peroxisome proliferator-activated receptor γ activation pathway in gastric cancer L Ramachandran, KA Manu, MK Shanmugam, F Li, KS Siveen, S Vali, ... Journal of Biological Chemistry 287 (45), 38028-38040, 2012 | 152 | 2012 |
| Inhibition of CXCR4/CXCL12 signaling axis by ursolic acid leads to suppression of metastasis in transgenic adenocarcinoma of mouse prostate model MK Shanmugam, KA Manu, TH Ong, L Ramachandran, R Surana, P Bist, ... International journal of cancer 129 (7), 1552-1563, 2011 | 148 | 2011 |
| Plumbagin inhibits invasion and migration of breast and gastric cancer cells by downregulating the expression of chemokine receptor CXCR4 KA Manu, MK Shanmugam, P Rajendran, F Li, L Ramachandran, HS Hay, ... Molecular cancer 10, 1-14, 2011 | 146 | 2011 |
| γ‐Tocotrienol is a novel inhibitor of constitutive and inducible STAT3 signalling pathway in human hepatocellular carcinoma: potential role as an antiproliferative, pro … P Rajendran, F Li, KA Manu, MK Shanmugam, SY Loo, AP Kumar, ... British journal of pharmacology 163 (2), 283-298, 2011 | 145 | 2011 |
| Immunomodulatory activities of Punarnavine, an alkaloid from Boerhaavia diffusa KA Manu, G Kuttan Immunopharmacology and Immunotoxicology 31 (3), 377-387, 2009 | 139 | 2009 |
| Antiangiogenic activity of ursolic acid M Kanjoormana, G Kuttan Integrative Cancer Therapies 9 (2), 224-235, 2010 | 125 | 2010 |
| Emodin suppresses migration and invasion through the modulation of CXCR4 expression in an orthotopic model of human hepatocellular carcinoma KA Manu, MK Shanmugam, TH Ong, A Subramaniam, KS Siveen, ... PloS one 8 (3), e57015, 2013 | 71 | 2013 |
| Celastrol attenuates the invasion and migration and augments the anticancer effects of bortezomib in a xenograft mouse model of multiple myeloma MK Shanmugam, KS Ahn, JH Lee, R Kannaiyan, N Mustafa, KA Manu, ... Frontiers in Pharmacology 9, 365, 2018 | 61 | 2018 |
| Anti-metastatic potential of Punarnavine, an alkaloid from Boerhaavia diffusa Linn. KA Manu, G Kuttan Immunobiology 214 (4), 245-255, 2009 | 61 | 2009 |
| Anti-cancer activity of novel dibenzo [b, f] azepine tethered isoxazoline derivatives MP Sadashiva, Basappa, S NanjundaSwamy, F Li, KA Manu, ... BMC chemical biology 12, 1-11, 2012 | 52 | 2012 |
| Inhibition of isoprenylcysteine carboxylmethyltransferase induces cell-cycle arrest and apoptosis through p21 and p21-regulated BNIP3 induction in pancreatic cancer KA Manu, TF Chai, JT Teh, WL Zhu, PJ Casey, M Wang Molecular cancer therapeutics 16 (5), 914-923, 2017 | 50 | 2017 |
| p21cip1/waf1 coordinates autophagy, proliferation and apoptosis in response to metabolic stress KA Manu, PHA Cao, TF Chai, PJ Casey, M Wang Cancers 11 (8), 1112, 2019 | 47 | 2019 |
| An anthraquinone derivative, emodin sensitizes hepatocellular carcinoma cells to TRAIL induced apoptosis through the induction of death receptors and downregulation of cell … A Subramaniam, SY Loo, P Rajendran, KA Manu, E Perumal, F Li, ... Apoptosis 18, 1175-1187, 2013 | 46 | 2013 |
| Effect of Punarnavine, an Alkaloid from Boerhaavia diffusa, on Cell-Mediated Immune Responses and TIMP-1 in B16F-10 Metastatic Melanoma-Bearing Mice KA Manu, G Kuttan Immunopharmacology and immunotoxicology 29 (3-4), 569-586, 2007 | 46 | 2007 |
