Michael Harms

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Joseph W. ThorntonUniversity of Chicago, Depts. of Human Genetics and Ecology & EvolutionVerified email at uchicago.edu
Lucas C. WheelerPostdoctoral Researcher, Smith lab, CU BoulderVerified email at colorado.edu
Zachary SailerApple Software Engineer | Jupyter Core Maintainer | PhD from Harms Lab, UOregonVerified email at apple.com
Geeta EickCourtesy Research Associate, University of OregonVerified email at uoregon.edu
Eric OrtlundEmory University School of MedicineVerified email at emory.edu
Jamie BridghamUniversity of OregonVerified email at uoregon.edu
Anneliese Jaehne MorrisonPhD student, University of OregonVerified email at my.fsu.edu
Shion A. LimGenentechVerified email at gene.com
Jen Colucci, Ph.D.Emory UniversityVerified email at emory.edu
Kathryn M HartWilliams CollegeVerified email at williams.edu
Franklin A. HaysUniversity of Oklahoma Health Sciences CenterVerified email at ouhsc.edu
P. Shing HoColorado State UniversityVerified email at colostate.edu
Carlos A CastanedaSyracuse University, Biology and Chemistry, Bioinspired InstituteVerified email at syr.edu
Daniel G. IsomUniversity of Miami School of MedicineVerified email at miami.edu
Ana DamjanovicJohns Hopkins, NIH, University of Illinois, UC BerkeleyVerified email at jhu.edu
Devrishi GoswamiResearch Associate, SCRIPPS Research InstituteVerified email at scripps.edu
Patrick R GriffinProfessor of Molecular Medicine, UF Scripps Biomedical ResearchVerified email at scripps.edu
Larry DavidProfessor of Biochemistry and Molecular Biology, Oregon Health & Science UniversityVerified email at ohsu.edu
James S PrellAssociate Professor of Chemistry, University of OregonVerified email at uoregon.edu
Kathleen B HallWashington University Medical SchoolVerified email at wustl.edu

Michael Harms

Associate Professor, Institute of Molecular Biology, University of Oregon

Verified email at uoregon.edu - Homepage

Protein evolution biophysics


Title Sort by citations Sort by year Sort by title	Cited by Cited by	Year
Evolutionary biochemistry: revealing the historical and physical causes of protein properties MJ Harms, JW Thornton Nature Reviews Genetics 14 (8), 559-571, 2013	361	2013
Analyzing protein structure and function using ancestral gene reconstruction MJ Harms, JW Thornton Current opinion in structural biology 20 (3), 360-366, 2010	260	2010
Protein evolution by molecular tinkering: diversification of the nuclear receptor superfamily from a ligand-dependent ancestor JT Bridgham, GN Eick, C Larroux, K Deshpande, MJ Harms, ... PLoS biology 8 (10), e1000497, 2010	258	2010
Arginine residues at internal positions in a protein are always charged MJ Harms, JL Schlessman, GR Sue, B García-Moreno E Proceedings of the National Academy of Sciences 108 (47), 18954-18959, 2011	189	2011
Historical contingency and its biophysical basis in glucocorticoid receptor evolution MJ Harms, JW Thornton Nature 512 (7513), 203-207, 2014	172	2014
How sequence defines structure: a crystallographic map of DNA structure and conformation FA Hays, A Teegarden, ZJR Jones, M Harms, D Raup, J Watson, ... Proceedings of the National Academy of Sciences 102 (20), 7157-7162, 2005	165	2005
The pKa values of acidic and basic residues buried at the same internal location in a protein are governed by different factors MJ Harms, CA Castañeda, JL Schlessman, GR Sue, DG Isom, ... Journal of molecular biology 389 (1), 34-47, 2009	155	2009
Evolution of minimal specificity and promiscuity in steroid hormone receptors GN Eick, JK Colucci, MJ Harms, EA Ortlund, JW Thornton PLoS genetics 8 (11), e1003072, 2012	139	2012
The thermostability and specificity of ancient proteins LC Wheeler, SA Lim, S Marqusee, MJ Harms Current opinion in structural biology 38, 37-43, 2016	137	2016
Detecting high-order epistasis in nonlinear genotype-phenotype maps ZR Sailer, MJ Harms Genetics 205 (3), 1079-1088, 2017	135	2017
High-order epistasis shapes evolutionary trajectories ZR Sailer, MJ Harms PLoS computational biology 13 (5), e1005541, 2017	111	2017
Robustness of reconstructed ancestral protein functions to statistical uncertainty GN Eick, JT Bridgham, DP Anderson, MJ Harms, JW Thornton Molecular biology and evolution 34 (2), 247-261, 2016	108	2016
A buried lysine that titrates with a normal pK_a: Role of conformational flexibility at the protein–water interface as a determinant of pK_avalues MJ Harms, JL Schlessman, MS Chimenti, GR Sue, A Damjanović, ... Protein Science 17 (5), 833-845, 2008	98	2008
Thermodynamic system drift in protein evolution KM Hart, MJ Harms, BH Schmidt, C Elya, JW Thornton, S Marqusee PLoS biology 12 (11), e1001994, 2014	96	2014
Biophysical mechanisms for large-effect mutations in the evolution of steroid hormone receptors MJ Harms, GN Eick, D Goswami, JK Colucci, PR Griffin, EA Ortlund, ... Proceedings of the National Academy of Sciences 110 (28), 11475-11480, 2013	79	2013
Molecular ensembles make evolution unpredictable ZR Sailer, MJ Harms Proceedings of the National Academy of Sciences 114 (45), 11938-11943, 2017	75	2017
Laser light‐scattering evidence for an altered association of βB1‐crystallin deamidated in the connecting peptide MJ Harms, PA Wilmarth, DM Kapfer, EA Steel, LL David, HP Bächinger, ... Protein science 13 (3), 678-686, 2004	49	2004
Multiple Evolutionary Origins of Ubiquitous Cu²⁺ and Zn²⁺ Binding in the S100 Protein Family LC Wheeler, MT Donor, JS Prell, MJ Harms PloS one 11 (10), e0164740, 2016	42	2016
Evolutionary trend toward kinetic stability in the folding trajectory of RNases H SA Lim, KM Hart, MJ Harms, S Marqusee Proceedings of the National Academy of Sciences 113 (46), 13045-13050, 2016	40	2016
pytc: Open-Source Python Software for Global Analyses of Isothermal Titration Calorimetry Data H Duvvuri, LC Wheeler, MJ Harms Biochemistry 57 (18), 2578-2583, 2018	27	2018

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