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Charles H. Chen
Charles H. Chen
Senior Scientist, Pharmaceutical Sciences, AstraZeneca
Verified email at astrazeneca.com - Homepage
Title
Cited by
Cited by
Year
Development and Challenges of Antimicrobial Peptides for Therapeutic Applications
CH Chen, TK Lu
Antibiotics 9 (1), 24, 2020
4122020
Spontaneous formation of structurally diverse membrane channel architectures from a single antimicrobial peptide
Y Wang, CH Chen, D Hu, MB Ulmschneider, JP Ulmschneider
Nature Communications 7, 13535, 2016
1092016
Simulation-guided rational de novo design of a small pore-forming antimicrobial peptide
CH Chen, CG Starr, EP Troendle, G Wiedman, WC Wimley, ...
Journal of the American Chemical Society, 2019
1022019
Catalysis with CuII (bpy) improves alkaline hydrogen peroxide pretreatment
Z Li, CH Chen, T Liu, V Mathrubootham, EL Hegg, DB Hodge
Biotechnology and bioengineering 110 (4), 1078-1086, 2013
532013
Absorption and folding of melittin onto lipid bilayer membranes via unbiased atomic detail microsecond molecular dynamics simulation
CH Chen, G Wiedman, A Khan, MB Ulmschneider
Biochimica et Biophysica Acta (BBA)-Biomembranes 1838 (9), 2243-2249, 2014
522014
Rapid and effective oxidative pretreatment of woody biomass at mild reaction conditions and low oxidant loadings
Z Li, CH Chen, EL Hegg, DB Hodge
Biotechnology for biofuels 6, 1-9, 2013
372013
Understanding and modelling the interactions of peptides with membranes: from partitioning to self-assembly
CH Chen, MCR Melo, N Berglund, A Khan, C de la Fuente, ...
Current Opinion in Structural Biology 61, 160-166, 2020
332020
Chemical and structural changes associated with Cu-catalyzed alkaline-oxidative delignification of hybrid poplar
Z Li, N Bansal, A Azarpira, A Bhalla, CH Chen, J Ralph, EL Hegg, ...
Biotechnology for Biofuels 8, 1-12, 2015
252015
Synthetic molecular evolution of antimicrobial peptides
C Chen, T Bepler, K Pepper, D Fu, T Lu
Current Opinion in Biotechnology 75, 102718, 2022
232022
Regioselective Hydroxylation of C12–C15 Fatty Acids with Fluorinated Substituents by Cytochrome P450 BM3
CH Chiang, R Ramu, YJ Tu, CL Yang, KY Ng, WI Luo, CH Chen, YY Lu, ...
Chemistry–A European Journal 19 (41), 13680-13691, 2013
232013
Tuning of a Membrane-Perforating Antimicrobial Peptide to Selectively Target Membranes of Different Lipid Composition
CH Chen, C Starr, S Guha, WC Wimley, MB Ulmschneider, ...
The Journal of Membrane Biology, 2021
152021
Mechanisms of Membrane Pore Formation by Amyloidogenic Peptides in Amyotrophic Lateral Sclerosis
CH Chen, A Khan, JJT Huang, MB Ulmschneider
Chemistry–A European Journal 22 (29), 9958–9961, 2016
142016
Mechanisms of a small membrane-active antimicrobial peptide from Hyla punctata
CH Chen, JP Ulmschneider, MB Ulmschneider
Australian Journal of Chemistry 73 (3), 236-245, 2020
112020
Integrated Design of a Membrane-Lytic Peptide-Based Intravenous Nanotherapeutic Suppresses Triple-Negative Breast Cancer
C Chen, YH Liu, A Eskandari, J Ghimire, LCW Lin, ZS Fang, W Wimley, ...
Advanced Science, 2022
102022
Proline-rich chaperones are compared computationally and experimentally for their abilities to facilitate recombinant butyrylcholinesterase tetramerization in CHO cells
Q Wang, CH Chen, C Chung, J Priola, JH Chu, J Tang, MB Ulmschneider, ...
Biotechnology Journal 13 (3), e1700479, 2018
82018
Exploring the Experience of Undergraduate Research: A Case Study Using facebook
K Luchini-Colbry, T Ortega-Knight, CH Chen, D Lynch, K Fitzsimons, ...
Proceedings of the 2013 ASEE National Conference. Atlanta, GA, 2013
52013
Development of membrane-active peptide therapeutics in oncology
C Chen, B Zan, J Ulmschneider, W Wimley, T Lu, M Ulmschneider, L Zhou
Journal of Peptide Science, 2023
42023
Optimization of Host Cell-Compatible, Antimicrobial Peptides Effective against Biofilms and Clinical Isolates of Drug-Resistant Bacteria
J Ghimire, RJ Hart, A Soldano, CH Chen, S Guha, JP Hoffmann, KM Hall, ...
ACS Infectious Diseases, 2023
32023
Pore Formation Mechanisms of Melittin-Like Membrane-Active Peptides
CH Chen, G Wiedman, Y Wang, A Khan, MB Ulmschneider
Biophysical Journal 108 (2), 497a-498a, 2015
12015
Optimization of host cell-compatible, antimicrobial peptides effective against biofilms and clinical isolates of drug-resistant bacteria
J Ghimire, JR Hart, A Soldano, C Chen, S Guha, J Hoffmann, K Hall, ...
bioRxiv, 2022
2022
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